Overall Progression Free Survival
Challenges and methodologies in using progression free survival as a surrogate for overall survival In oncology
... of progression among clinical trials and a lack of clear information in the clinical trial reports as to how disease progression was evaluated (15,17,40) indicate that there is a need to standardise ...
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Progression-free survival as a potential surrogate for overall survival in metastatic breast cancer
... Dovepress surrogate markers for overall survival in advanced breast cancer considered minimal. Furthermore, in the present study, the relationship between PFS/TTP and OS was assessed using a trial-based ...
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Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer
... to progression) in the evaluation of the treatment of ...of survival in the evaluation of neoadjuvant treatment of non–small cell lung ...of survival in the treatment of glioblastoma, 20 renal cell ...
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Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer
... to progression) in the evaluation of the treatment of ...of survival in the evaluation of neoadjuvant treatment of non–small cell lung ...of survival in the treatment of glioblastoma, 20 renal cell ...
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Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2– metastatic breast cancer
... OS. Progression-free survival (PFS) is defined as the time from randomization to tumor progression or ...tumor progression or following adverse events related to ...to ...
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Statistical models to capture the association between progression-free and overall survival in oncology trials
... control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast can- cer, Journal of Clinical Oncology, 26 (2008), ...
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Development and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer
... Cancer-Overall-Survival-Calculator ; https://www.nrgoncology.org/ Nomograms/Oropharynx-Cancer-Progression-Free-Survival- Calculator ). These estimates might allow patients to determine ...
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Assessment of progression-free survival as a surrogate end-point for overall survival in patients with metastatic renal cell carcinoma
... associated with longer PPS, and the three PPS curves were significantly different (P < 0.0001; Fig. 4 ). 4. Discussion In this study, a discernible and quantifiable positive relationship was found between PFS and PPS ...
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Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials
... Completed phase II, III, and IV trials in glioblastoma published between January 1, 1991 and June 4, 2012 were identified through a systematic search on MEDLINE/PubMed and Trialtrove (Citeline) using the following ...
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Progression-free survival as a surrogate endpoint for overall survival in patients with third-line or later-line chemotherapy for advanced gastric cancer
... median overall survival (OS) of one year in patients treated with the commonly used first-line chemotherapy regimens (fluoropyrimidine plus a platinum agent with or without docetaxel or ...disease ...
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Is progression-free survival a more relevant endpoint than overall survival in first-line HR+/HER2− metastatic breast cancer?
... Conclusion The goal of treatment in MBC is to prolong life while main- taining the quality of survival. As such, RCTs of MBC treat- ments ideally measure OS and HRQoL. In clinical trials of 1L therapies, OS is ...
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Negative effect of hepatitis in overall and progression-free survival among patients with diffuse large B-cell lymphoma
... existed. Progression-free survival (PFS) and overall survival (OS) were estimated by using the Kaplan-Meier method ...follow-up. Survival curves differences were analyzed using ...
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Diffusion MR Characteristics Following Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma.
... The standard of care for newly diagnosed glioblastoma (GBM) is surgery first, radiotherapy (RT) with concur- rent temozolomide (TMZ) second, and adjuvant TMZ last. We hypothesized patients with low diffusivity mea- sured ...
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Calpain 2 expression is associated with response to platinum based chemotherapy, progression free and overall survival in ovarian cancer
... with progression-free (P = 0.049) and overall survival (P = ...and overall survival remained significant in multivariate analysis accounting for tumour grade, stage, optimal ...
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Original Article Impact of LGR5 in colorectal cancer on overall and progression-free survival: a systematic review and meta-analysis
... detection. Overall, the finally analysis showed that LGR5 positive expression predict- ed poor prognosis of CRC ...from survival curves in the published ...
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Post-progression survival and progression-free survival in patients with advanced hepatocellular carcinoma treated by sorafenib
... median overall survival (OS) and median post-progression survival (PPS) and (B) relationship between median OS and median progression-free survival (PFS) or median time to ...
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Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer
... disease progression or death from any cause, where the progression status was typically based on preresponse evaluation criteria in solid tumors (pre-RECIST; 8 of 10 ...the progression status into ...
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Elevated CRP levels indicate poor progression-free and overall survival on cancer patients treated with PD-1 inhibitors
... Even though results of the current study are convincing, they are hypothesis generating. Prospective trials should investigate whether patients with elevated markers for systemic inflammation gain any significant benefit ...
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Elevated CRP levels indicate poor progression-free and overall survival on cancer patients treated with PD-1 inhibitors
... Even though results of the current study are convincing, they are hypothesis generating. Prospective trials should investigate whether patients with elevated markers for systemic inflammation gain any significant benefit ...
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Secondary malignant neoplasms, progression-free survival and overall survival in patients treated for Hodgkin lymphoma: A systematic review and meta-analysis of randomized clinical trials
... plasms, progression-free survival and overall survival is reported in the meta-analysis herein, based on individual patient data from 9498 patients treated within 16 randomized ...
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