Oxidized LDL
Induction of heme oxygenase 1 inhibits the monocyte transmigration induced by mildly oxidized LDL
... formed oxidized LDL may evoke the HO-1 gene response continuously (32, ...copper-oxidized LDL yielded similar results in porcine aortic smooth muscle cell cultures (38, ...in oxidized ...
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<p>Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL</p>
... Chronic in fl ammation plays an important role in the pathogenesis of atherosclerosis. Oxidized-LDL (ox-LDL) initiates endothelial injury and in fl ammation, which leads to the development of ...
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PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
... upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse ...of oxidized LDL (oxLDL) into ...
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Multivessel coronary artery disease, free fatty acids, oxidized LDL and its antibody in myocardial infarction
... Measuring oxidized low-density lipoprotein (oxidized LDL), which plays an important role in atherosclerotic plaque formation and destabilization, as well as in the acti- vation of systemic ...
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Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio
... mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and paraoxonase ...in LDL receptor knockout mice when they were fed a ...mildly ...
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Bilirubin is independently associated with oxidized LDL levels in young obese patients
... Bilirubin has important antioxidant and anti-inflammatory properties. Actually, bilirubin can protect low-density lipo- protein (LDL) from oxidation [1] and persons expressing Gilbert syndrome (i.e., unconjugated ...
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Gluten free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study
... interest. Oxidized or other types of modified LDL generally are believed to be of importance in atherosclerosis and CVD since such LDL is taken up in the artery wall by macrophages and has immune ...
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Oxidized LDL activates fas mediated endothelial cell apoptosis
... Copper-oxidized LDL has been widely used to study the biological activity of OxLDL (10, 11, 35, 36), but a recent study suggests that copper-oxidized LDL may not represent the rele- vant form ...
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Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type 2 Diabetes Mellitus
... mean LDL-Cholesterol was found to be sig- nificantly increased in cases of ...0.001). Oxidized LDL levels in the positive cases was found to be increased significantly (P = ...Triglycerides, ...
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Disease Activity, Oxidized-LDL Fraction and Anti-Oxidized LDL Antibodies Influence Cardiovascular Risk in Rheumatoid Arthritis
... A venous blood sample was collected from each participant under fasting conditions. TC, HDL-C, LDL-C and TG concentrations in both groups were measured in a certified commercial laboratory. In the RA group, the ...
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IL 5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
... atherogenesis, LDL is oxidized, generating various oxidation-specific neoepitopes, such as malondialdehyde-modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup of ...
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Oxidized LDL is Correlated with Urine Albumin in Type 2 Diabetes Mellitus: A Case-Control Study
... Ox- LDL in the plasma were unavailable ...increase LDL oxidation in diabetic patients in previous studies ...of LDL to oxidation in diabetic ...dense LDL, which is more prone to oxidation than ...
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Subendothelial retention of lipoprotein (a) Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix
... creased 2–10-fold when the HSPG were removed by heparin- ase treatment. Incubation of endothelial cells with oxidized LDL (OxLDL) or lysolecithin resulted in decreased matrix proteoglycans and increased ...
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Relationship between biomarkers of inflammation, oxidative stress and endothelial/microcirculatory function in successful aging versus healthy youth: a transversal study
... (oxidized LDL-cholesterol), inflammatory biomarkers (sVCAM, sICAM, sE-Selectin, interleukines 1 and 6, TNF-α and C-reactive protein) and some classical cardiovascular risk factors (lipidogram, fibrinogen) ...
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Oxidatively modified LDL contains phospholipids with platelet activating factor like activity and stimulates the growth of smooth muscle cells
... copper-oxidized LDL and assayed for PAF-like ...from oxidized LDL and purified by HPLC induced neutrophil adhesion equivalent to PAF (10 nM) and were mitogenic for smooth muscle ...
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Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
... Several surface receptors were reported to be involved in phagocytosis and the interaction of micro- glia/mononuclear phagocytes with fibrillar Ab or b- amyloid plaques. Scavenger receptors are strongly expressed in ...
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Effects of copper sulfate-oxidized or myeloperoxidase- modified LDL on lipid loading and programmed cell death in macrophages under hypoxia
... of oxidized LDL, these metabolic changes may lead to a lesser production of reactive oxygen species within the cells, hence the lower toxicity of these oxidized LDL under ...
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Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1
... with oxidized LDL and incubated with HDL alone or HDL plus LXR agonist (T0901317) in: 1) the intracellular content of oxysterols and total sterols and 2) the contents of ABCA-1 and ...
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Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... of LDL, and atherosclerosis lesion development? The 12/15-lipoxygenases are cytosolic intracellular enzymes that can interact with plasma membrane or intracellular sites to access their ...extracellular LDL ...
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The effects of oxidized low density lipoproteins on inducible mouse macrophage gene expression are gene and stimulus dependent
... with oxidized LDL. Furthermore, the ability of oxidized LDL to suppress gene expression varied markedly with the inducing stimulus ...by oxidized LDL than that induced by ...by ...
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