oxygen-glucose deprivation
Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation
... Background: The major damaging factor during and after the ischemic/hypoxic insult is the generation of free radicals, which leads to apoptosis, necrosis and ultimately cell death. Rubia cordifolia (RC), Fagonia cretica ...
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Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells
... Fig. 7 The expression of BDNF receptors and downstream at 24 h after reperfusion. Neuron cells were infected with lentivirus shRNA-Huwe1 or lentivirus shRNA-Gadd45b, followed by OGD and reperfusion 24 h. Cells were ...
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Original Article miR-148a regulates inflammation in microglia induced by oxygen-glucose deprivation via MAPK signal pathways
... Abstract: Inflammation occupies an important place in the progression of acute ischemic strokes. Microglia, a kind of resident immune cell in the central nervous system (CNS), plays a vital role in neuroinflammatory ...
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Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells
... Mounting evidence suggests neuro-inflammation is a key contributor to the severity of CNS hypoxia-ischaemia injury. To model this hypoxia-ischaemia environment in vitro we utilised an oxygen glucose ...
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Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation
... Background: It is generally recognized that the inflammatory reaction in glia is one of the important pathological factors in brain ischemic injury. Our previous study has revealed that opening ATP-sensitive potassium ...
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β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices
... by oxygen-glucose deprivation (OGD) and thereafter transfer to fresh medium for 48 h; Oxy- gen-glucose deprivation (OGD) = preincubation without LPS for 24 h, followed by OGD and ...
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Differential cytokine expression by brain microglia/macrophages in primary culture after oxygen glucose deprivation and their protective effects on astrocytes during anoxia
... if oxygen glucose deprivation (OGD) can trigger expression of phenotype-specific markers in rat microglia/macrophages in primary culture, in absence/low abundance of other brain ...
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Original Article Propofol prevents against oxygen glucose deprivation and reperfusion-induced autophagic cell death in H9c2 cells by increasing miR-30
... on oxygen glucose deprivation and reperfusion (OGD/R)-induced autophagic cell death in cardiomyoblasts and explore possible molecular ...of oxygen and glucose, and then reoxygenated in ...
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Original Article Ginsenoside Rd pretreatment attenuates apoptosis of PC12 cells induced by oxygen-glucose deprivation
... Abstract: The current study explored the inhibitory mechanisms of ginsenoside Rd on apoptosis of PC12 cells in- duced by oxygen-glucose deprivation (hypoxia). An in vitro cell model was established. ...
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<p>Thymosin β4 prevents oxygen-glucose deprivation/reperfusion-induced injury in rat cortical neurons</p>
... Thymosin (T) β 4 is a polypeptide composed of 43 amino acids that is widely distributed in the body. T β 4 is puri fi ed from the thymus 4 and was shown to enhance angiogenesis and wound healing by promoting the ...
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Original Article Silenced Notch1 attenuates autophagy in PC12 cells following oxygen-glucose deprivation-induced injury
... Abstracts: Ischemic cerebrovascular disease (ICD) or ischemic stroke is one of the most severe and common neuro- logical diseases in the elderly population. Autophagy is a highly conserved process in eukaryotes and a key ...
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Original Article Role of GSK-3β inhibitor TWS119 in protecting neurons against oxygen-glucose deprivation injury
... Abstract: Aim: Glycogen synthase kinase-3 (GSK-3) is one of the few signaling molecules that regulates a truly astonishing number of critical intracellular signaling pathways.TWS119 is a GSK-3β inhibitor with IC50 of 30 ...
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Original Article Paeoniflorin down-regulates the expression of NLRP1 and NLRP3 inflammasomes in rat hippocampal slices after oxygen-glucose deprivation
... to oxygen- glucose-deprived organotypic hippocampal slice ...against oxygen-glucose deprivation (OGD)-induced neuronal cell death and demonstrated the ability to downregulate the levels ...
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Original Article Tanshinone IIA pretreatment attenuates oxygen-glucose deprivation induced hippocampal neurons damage
... Abstract: Objective: Tanshinone IIA (Tan IIA) has been used in treatment of ischemic stroke in China. This study was designed to investigate the underlying neuroprotective mechanism of Tan IIA pretreatment in primary ...
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Original Article Protective effect of catalpol on oxygen glucose deprivation neurons
... Abstract: Brain ischemia is one common cerebrovascular disease with unfavorable prognosis and higher morbidity and mortality rates. The re-perfusion injury after primary ischemia further aggravated the progression of ...
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Neuroprotection and cellular survival bygingko biloba extract in an in vitro murine model of ischemic stroke
... reactive oxygen species andacute inflammation, which lead to the disruption of cellular homeostasis and structural damage of ischemic brain ...to oxygen–glucose deprivation[OGD]/reperfusion) ...
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LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke
... Methods: Oxygen-glucose deprivation in primary microglial cells and transient middle cerebral artery occlusion (MCAO) in C57BL/6 mice were used as the in vitro and in vivo ischemic stroke ...
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Maximizing neuroprotection: where do we stand?
... of oxygen-glucose deprivation and brief exposure to a high concentration of the NMDA or glutamate provide neuroprotection by reducing the release of glutamate and other EAAs into the extracellular ...
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Oxygen deprivation induced injury to isolated rabbit kidney tubules
... of oxygen deprivation-induced injury and recovery were developed and alterations of injury-related metabolic parameters in these models were characterized in ...When oxygen deprivation was ...
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The effects of ontogeny and environmental oscillations on plant responses to oxygen deprivation
... embryo oxygen uptake when the seed is returned to air, compared with seeds not previously allowed to imbibe ...of oxygen during the first stages of imbibition may be connected with the need to establish and ...
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