oxygenase-1
Heme oxygenase 1 is a modulator of inflammation and vaso occlusion in transgenic sickle mice
... heme oxygenase-1 ...heme oxygenase-1 expression and inhibits hypoxia/reoxygenation–induced stasis, leukocyte-endothelium interactions, and NF- kB, VCAM-1, and ICAM-1 ...Heme ...
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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
... biochemically, and genetically distinct from apoptosis, various forms of necrosis, and autophagy. This process is characterized by the overwhelming, iron-dependent accumulation of lethal lipid ROS [8]. Unlike other forms ...
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Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia
... Factors that trigger the clinical signs of preeclampsia originate from the placenta. Confirmation of the presence of Hmox in the placenta is important to determine its role in preeclampsia. Indeed, over the last two ...
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Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia
... heme oxygenase-1 (HO-1) is very important in ...heme oxygenase-1 level with onset and severity in normotensive pregnancy and severe ...heme oxygenase-1 level in ...
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Inductive transcription and protective role of fish heme oxygenase 1 under hypoxic stress
... Heme oxygenase-1 is the rate-limiting enzyme in the degradation of heme into biliverdin, carbon monoxide and free divalent ...heme oxygenase isoform 1 (CaHO-1) from a hypoxia-tolerant ...
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Heme oxygenase-1 regulates mitochondrial quality control in the heart
... Heme oxygenase-1 overexpression protects cardiomyocytes from doxorubicin-mediated ...heme oxygenase-1 (HO-1) overexpressing (HBAC) mice 14 days after doxorubicin (DOX) ...bar: 1 ...
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Heme oxygenase-1: emerging target of cancer therapy
... Heme oxygenase-1 (HO-1) was initially identified as a liver microsomal protein with activity to degrade heme to bilirubin four decades ago ...
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Heme oxygenase 1 deficiency accompanies neuropathogenesis of HIV associated neurocognitive disorders
... heme oxygenase isoforms (HO-1 and HO-2) are expressed to varying levels in nearly all cell lineages, but only HO-1, the rapidly inducible isoform, is considered to be a criti- cal mediator of the ...
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ATF4 dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis
... role of ATF4 in these processes as well as the mechanistic basis for such a role has not been elucidated. Here, we have focused on the specific role that ATF4 plays in metastatic behavior, including migration, invasion, ...
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
... heme oxygenase-1 (HO-1) is significantly reduced in brain prefrontal cortex of HIV-positive individuals with HIV-associated neurocognitive disorders ...
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The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication
... Heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting step in heme degradation, has antioxidative properties and protects cells from various ...
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Pharmacological Inhibition of Host Heme Oxygenase 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes
... In this study, we identify heme oxygenase-1 (HO-1) as a po- tential target for HDT of TB. This antioxidant enzyme, which catalyzes heme degradation into biliverdin, iron, and carbon monoxide (3), is ...
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Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect
... Heme oxygenase-1; LC3: microtubule-associated protein 1 light chain 3; XIAP: X-linked inhibitor of apoptosis; TMT: Tandem mass tag; PI: propidium iodide; HIV: Human Immunodeficiency Virus; KSHV: ...
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DMO CAP inhibits influenza virus replication by activating heme oxygenase 1 mediated IFN response
... Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades pro-oxidant heme into equimolar quantities of carbon monoxide (CO), iron, and biliverdin ...
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Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase 1
... erythrocytes that surround the brain contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ dysfunction. Free heme is ...
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Disrupted postnatal lung development in heme oxygenase-1 deficient mice
... Antenatal and postnatal steroid therapy benefits preterm infants by accelerating lung maturation, reducing lung inflammation and facilitating extubation from the ventila- tor [33,34]. However, the adverse effects ...
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Regulatory role of heme oxygenase-1 in silica-induced lung injury
... We have reported that the anti-oxidant protein HO-1 could be a key monitoring parameter as well as a poten- tial therapeutic for silicosis [20, 21]. The present study demonstrated for the first time that ...
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Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase 1 but not paraoxonase 1 induction in cultured hepatocytes role of the redox regulated transcription factor Nrf2
... cose (4 g/l) Dulbecco ’ s modified Eagle ’ s medium with 10% heat inactivated foetal bovine serum, 100 U/ml penicillin, 100 μ g/ml streptomycin and 100 μ g/ml G418 (all from PAA, Coelbe, Germany). For cell culture stu- ...
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Heme oxygenase-1 in macrophages controls prostate cancer progression
... E-cadherin plays a critical role in the function of the epithelial layer and is lost during EMT. E-cadherins are also recognized by Killer cell lectin-like receptor subfamily G member 1 (KLRG1) receptor on NK ...
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Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation
... To address further the mechanism by which HO-1 suppressed MHC class II expression in CNS APCs, we tested whether induc- tion of HO-1 in microglial BV2 cells would inhibit MHC class II expression. When ...
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