p-AMPK
Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti obesity and hypolipidemic effects by activating adenosine monophosphate activated protein kinase (AMPK)
... portant. AMPK agonists and PPARγ antagonists ap- pear to be involved in adipocyte differentiation and thus can be potential drugs for the treatment of obes- ity ...increased p-AMPK ex- pression in ...
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Original Article Phosphorylated AMP-activated protein kinase expression is significantly associated with poor clinical outcomes in bladder carcinoma patients
... development. AMPK controls cellular proliferation and assesses the checkpoints of the cell cycle of tumor cells after energy resources ...with p-AMPK immunostaining in urinary bladder ...
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<p>Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway</p>
... 1 mL of protein extract was added to the cell suspension to extract the protein, and the solution was blown repeat- edly to facilitate the cell lysis. This solution was centri- fuged at 4°C at 1.6×10 4 ×g for 20 min. The ...
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<p>Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA <em>TUG1</em> to Induce Autophagy and Inhibit Atherosclerosis</p>
... (B) p-AMPK/AMPK, (C) p-mTOR/mTOR, (D) ATG3, (E) p62, and (F) LC3II/LC3I protein levels after cells were transfected with si-TUG1 or incubated with Compound C ...
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Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
... activate AMPK and increase the level of p-AMPK (Figure ...the AMPK inhibitor, dorsomorphin, could not rescue the cell death induced by Phen or Met (Figure 5B), which suggested that Phen- or ...
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Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion
... was AMPK-dependent or not, we analyzed the effect of metformin at a cellular level, using OGD models to mimic in vivo ischemia/reperfusion ...increase p- AMPK in vitro. We found that there was an ...
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<p>Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway</p>
... of AMPK/ mTOR signaling pathway is associated with a variety of cancers including non-small cell lung cancer, 19 pancreatic cancer 20 and ...whether AMPK/mTOR pathway is implicated in the FASN-mediated CRC ...
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CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma
... Abstract: Osteosarcoma (OS) is the most common primary bone tumor, but molecular mechanisms of the disease have not been well understood, and treatment of metastatic OS remains a challenge. Rapid ribosomal RNA synthesis ...
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miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease
... Moreover, AMPK has been found to augment Sirt1 activity via elevating cellular NAD + levels (Canto et ...and AMPK (Lan et al., 2008). To investigate whether the LKB1/AMPK pathway is required for the ...
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Original Article Rapamycin protects against hepatic injury in streptozotocin-induced diabetic rats by enhancing autophagy
... phosphorylated AMPK (P-AMPK), microtubule-associated protein 1 light chain 3 (LC3) (Abcam, Cambridge, MA, USA), m-TOR (Sigma-Aldrich), Beclin-1 (Sigma-Aldrich) or GAPDH (Santa Cruz Biotechnology, ...
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<p>Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells</p>
... Western blot analysis was used to determine the expression of proteins (LC3-II, p62, phospho-AMPK α , phospho-mTOR, mTOR, phospho-p70 S6 Kinase, p70 S6 Kinase, PARP1, Caspase-9 and Caspase-3). The experiments were ...
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Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling
... that AMPK also acts in the suppression of inflam- matory responses [34, 35], and the phosphorylation of the threonine 172 residue within the catalytic subunit (p-AMPK) plays a pivotal role in its ...
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Explore the Relationship between Insulin Resistance and PGC1α in PCOS Mice
... In conclusion, we have come to realize that each cell in the body controls its growth and life status, usually through a network of molecular signals of envi- ronmental matter and energy supply. In this study, we first ...
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Disruption of fyn SH3 domain interaction with a proline rich motif in liver kinase B1 results in activation of AMP activated protein kinase
... -(T172)- AMPK, total-AMPK and total-ACC antibodies were from Cell Signaling (Danvers, MA,USA), LKB1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA,USA) and Millipore (Billerica, MA,USA), ...
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Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene In curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells
... activated AMPK and subsequently inhibited the activation of NF-κB in human colon cancer cells, demonstrating that curcumin suppressed NF- κB via AMPK activation ...induces AMPK activation in ovarian ...
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Targeting AMPK for cancer prevention and treatment
... in AMPK activation and inhibition of downstream mTOR signaling ...activate AMPK there is regulation of other inflammatory regulatory ...lung, AMPK activation can alleviate inflammation that results ...
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An Understanding of Diabetes Mellitus Associated Complications, Treatment Modalities and Management Strategies
... Navarro P, Li M, Qi L, Steinthorsdottir V, Scott R.A., Almgren P, Arking ...Kraft P, Labrune Y, Langenberg C, Manning ...Froguel P, Palmer ...
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“AMPing up” our understanding of the hypothalamic control of energy balance
... of AMPK in POMC and NPY/AgRP neurons ...of AMPK in AgRP neurons reduced body ...that AMPK signaling in POMC and AgRP cells is necessary for proper long- term energy ...
5
Metformin interferes with bile acid homeostasis through AMPK FXR crosstalk
... and AMPK suggest that they con- stitute an integration platform for metabolic signals (18, 19), we evaluated whether FXR can interact physically with proteins of this platform (Supplemental Figure 2, B and ...
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miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone
... that AMPK activation inhibits Dex-induced ROS production, therefore protecting osteoblasts/osteoblastic cells ...Significantly, AMPK knockdown or dominant negative mutation almost completely abolished ...
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