P-glycoprotein
Intestinal P glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis
... surface, P-glycoprotein (P-gp), is actively reduced at the epithelial surface by Salmonella typhimurium (16, 17), the significance of which was previously ...unclear. P-gp is a multidrug ...
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St Johns wort increases expression of P glycoprotein: implications for drug interactions
... of P-glycoprotein, which then actively trans- ports drug substrates out of the cell lowering their intracellular drug concentration and facilitating the devel- opment of drug resistance [21, ...27±29]. ...
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INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN
... is P- glycoprotein, a ‘pump’ found in cell membranes (gut, blood-brain barrier etc), which affects serum drug levels by blocking or facilitating entry into ...
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Regulation of biliary lipid secretion by mdr2 P glycoprotein in the mouse
... Disruption of the mdr2 gene in mice leads to a complete absence of phospholipid from bile (Smit, J. J. M., et al. 1993. Cell. 75:451-462). We have investigated the control of both mdr2 P-glycoprotein (Pgp) ...
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Glucocorticoid access to the brain: involvement of the efflux transporter P-glycoprotein
... The synthetic glucocorticoids prednisolone and dexamethasone are widely used as anti- inflammatory and immunosuppressive drugs, because of their potent glucocorticoid actions in combination with their low ...
192
Quantitative Investigation of the Impact of P-glycoprotein Inhibition on Drug Transport
... drugs. P-gp also functions at the blood-brain barrier (BBB) and facilitates the excretion of potentially toxic xenobiotics (Tsuji et ...of P-gp-mediated drug-drug interaction (DDI) has become important for ...
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Resistance to paclitaxel in a cisplatin resistant ovarian cancer cell line is mediated by P glycoprotein
... of P-glycoprotein (P-gp) is increased in IGROVCDDP (Table 2), and there is a corresponding increase in protein expression (Figure ...increase P-gp expression in both IGROV-1 and IGROVCDDP but ...
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MEMANTINE, AS A P GLYCOPROTEIN EXPRESSION MODULATOR, ENHANCES LEVETIRACETAM THERAPEUTIC RESPONSE IN EPILEPTIC PATIENTS
... is P-glycoprotein (P-gp) or ATP-binding cassette subfamily B member 1 protein ...as P-gp substrates with variable degrees, including levetiracetam (LEV) ...
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HIV 1 integrase inhibitors are substrates for the multidrug transporter MDR1 P glycoprotein
... of P- glycoprotein, the drug-sensitive CEMrev cell line was used; this cell line derives from the CEM-VBL10 MDR cell line, cultured for more than 2 years in VBL-free medium and expresses very low (1–3%) or ...
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The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats
... of P-gp may be affected by some modulating or inhibiting agents ...the P-gp substrates or may themselves be sub- strates of ...a P-gp substrate when used in low doses, while high doses of verapamil ...
6
Absence or pharmacological blocking of placental P glycoprotein profoundly increases fetal drug exposure
... drug-transporting P-glycoprotein (P-gp), originally discovered in multidrug resistant (MDR) tumor cells (1), belongs to the superfamily of ATP binding cassette pro- teins (2, ...humans, P-gp ...
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The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo
... membranal P-glycoprotein (P-gp) is believed to be one major cause of cancer MDR [4, ...5]. P-gp, also known as ATP binding cas- sette subfamily B member 1 (ABCB-1) or MDR1, is a member of the ...
21
P-glycoprotein-targeted photodynamic therapy boosts cancer nanomedicine by priming tumor microenvironment
... nanomedicines. P-glycoprotein (Pgp) is a primary cause for multidrug resistance (MDR) in cancers [5], and its overexpression has been found to be associated with treatment failure in more than half of human ...
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P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
... Carbonic anhydrase XII (CAXII) is a membrane enzyme that maintains pH homeostasis and sustains optimum P-glycoprotein (Pgp) efflux activity in cancer cells. Here, we investigated a panel of eight CAXII ...
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RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric cancer cells
... of P-glycoprotein (P-gp) in MKN-45 stably transfected with RhoGDI2 expressing or control ...with P-gp expression in gastric cancer tissues as detected by ...up-regulates P-gp ...
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Effect of Verapamil on P-Glycoprotein Expression in Breast Carcinoma
... es P-glycoprotein and cancer stem cell expres- sions in MCF-7 cell ...of P- glycoprotein may be an important clinical and pathologic feature of breast cancer and a predic- tor of poor overall ...
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An in vitro evaluation of guanfacine as a substrate for P-glycoprotein
... Background: With a US Food and Drug Administration-labeled indication to treat attention-deficit/hyperactivity disorder (ADHD), the nonstimulant guanfacine has become the preferred α 2 -agonist for ADHD treatment. ...
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IMPROVING THE EFFICACY OF CYCLOPHOSPHAMIDE BY USING VERAPAMIL AS A P-GLYCOPROTEIN INHIBITOR IN BREAST CARCINOMA
... of P-glycoprotein (P-gp) which is associated with a poor prognosis in ...Consequently, P-gp represents a potential biomarker of drug ...of P-gp as a cause of clinical drug resistance ...
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Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti Inflammatory P Glycoprotein Pathway
... vitro P-glycoprotein expression ...predict P-glycoprotein expression as a function of the bacterial relative abundances obtained from whole-genome sequencing of elders with Alzheimer’s disease ...
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Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
... as P‑glycoprotein (P‑gp), that function to efflux potentially harmful compounds from the CNS back into the ...on P‑gp function would be important for potential routes of thera‑ peutic ...
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