P-glycoprotein (MDR-1)
Generation of a drug resistance profile by quantitation of mdr 1/P glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen
... of mdr-1/P-glycoprotein was measured by quantitative ...of mdr-1 and cellular resistance to a large number of ...are P-glycoprotein substrates includes: (a) ...
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Characterisation of P glycoprotein 9 1 in Haemonchus contortus
... Murine P-glycoprotein iso- form 1A; MDR: Multidrug-resistance; mdr1: Human multidrug resistance gene 1; MgCl: Magnesium chloride; ML: Macrocyclic lactone; mM: Mili molar; μ M: Micro molar; ...
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HIV 1 integrase inhibitors are substrates for the multidrug transporter MDR1 P glycoprotein
... adherent MDR variant ...of P- glycoprotein, the drug-sensitive CEMrev cell line was used; this cell line derives from the CEM-VBL10 MDR cell line, cultured for more than 2 years in VBL-free ...
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MDR1/P glycoprotein and MRP 1 drug efflux pumps in pancreatic carcinoma
... Patients. The patient group studied comprised of 45 consenting patients with primary tumours of the pancreas. All patients were treated at St. Vincent’s University Hospital (SVUH), Dublin, between 1999 and 2003 and ...
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Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity
... Rat of different ages were weighed using a digital scale. All animals were then anesthetized with ketamine (87 mg/kg)/xylazine (13 mg/kg) and placed in a rodent stereotaxic apparatus. Skin and cranial fascia were ...
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pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells
... reducing P-gp activity of human breast cancer cells (MCF-7/MDR) were evaluated and compared with that of 1,2 distearoyl-sn-glycero-3- phosphoethanolamine-N-[methoxy(polyethylene glycol)] (DSPE-PEG) serving ...
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Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
... tested MDR chemotherapeutic ...on MDR cells is enhanced in the presence of a large array of compounds recognized as MDR1-Pgp substrates which include cyto- toxic agents together with certain classes of ...
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Gene rearrangement: a novel mechanism for MDR 1 gene activation
... express P-glycoprotein on their surface (20) and, when analyzed, were found to have hybrid messages isolated with the 59 RACE system and primers GSP1 and ...of MDR-1 in leu- kemia samples ALL ...
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ATP-binding cassette (ABC) transporters in normal and pathological lung
... as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are highly expressed in bronchial ...
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MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
... factor; MDR: Multidrug resistance; MDR1: MultiDrug resistance protein 1, also called P-glycoprotein-170; MRP1: Multidrug resistance related protein 1; MDQ Assay: MultiDrug quant assay ...
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Original Article Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1)
... of P-glycoprotein is inhibited ...and P-glycoprotein have a synergic relationship in the pathogenesis of ...of P-glycoprotein may involve its pharmacological effects against ...
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A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat
... A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and ...
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Targeting multidrug resistance in cancer by natural chemosensitizers
... (MDR). MDR is a phenomenon by which cancer cells develop broad resist- ance to a wide variety of structurally and functionally unrelated compounds which may arise from several mechanisms of which the best ...
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Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers
... of P-glycoprotein (P-gp) requires its efficient localization to caveolae, a subset of lipid rafts, and disruption of caveolae suppresses P-gp transport ...of P-gp into caveolae remain ...
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REVERSAL OF MULTI-DRUG RESISTANCE IN MDR CANCER CELL BY 3113, A NEW DIPEPTIDOMIMETIC OF P-AMINOBENZOIC ACID
... of p- aminobenzoic acid showed multi-drug resistance (MDR) reversal ...In MDR cancer cells, no matter acquired or inherent, combination with 3113 enhanced doxorubicin (DXR) cytotoxicity by 8 to 10 ...
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Heparin’s anti inflammatory effects require glucosamine 6 O sulfation and are mediated by blockade of L and P selectins
... Thioglycollate-induced peritoneal inflammation. Mice were injected intraperitoneally with 2 ml of 3% thioglycol- late broth (lot no. 54H4607; Sigma-Aldrich) or sterile pyrogen-free saline (GIBCO BRL; Life Technologies ...
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The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P
... G glycoprotein might alter respiratory rates, we examined respiratory rates in unre- strained, spontaneously breathing 6- to 10-week-old female BALB/c mice, free of specific pathogens (Jackson Laborato- ries, Bar ...
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E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases
... stroke onset, in association with the clinical improve- ments seen in patients [8]. A second endothelial acti- vation leads to the production of CAMs at the end of the second week after stroke. This production could ...
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Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy
... Western blot was performed on whole cell lysates by incubating the cells in the lysis buffer (10 mM Tris pH 6.8, 1 mM EDTA, 10% NP40, 1 mM PMSF, 0.1% SDS) on ice for 30 minutes. Cell debris was removed by ...
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The cytokine adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney Inhibition by a soluble P selectin ligand
... Both MHC class II expression and subsequent cell migra- tion to the injured kidney were suppressed by sPSGL. This pu- tatively diminished immunogenicity of the organ may have im- portant clinical ramifications, as it may ...
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