P-glycoprotein (P-gp)
The Effect of the Dynamic Interplay of P-glycoprotein and Cytochrome P450 3A on the Portal Bioavailability of Dual Substrates
... as P-glycoprotein (P-gp) and metabolic enzymes, such as Cytochrome P450 3A (CYP3A) (Chapters ...that P-gp and CYP3A not only affect intestinal absorption individually, but they ...
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IMPROVING THE EFFICACY OF CYCLOPHOSPHAMIDE BY USING VERAPAMIL AS A P-GLYCOPROTEIN INHIBITOR IN BREAST CARCINOMA
... of P-glycoprotein (P-gp) which is associated with a poor prognosis in ...Consequently, P-gp represents a potential biomarker of drug ...of P-gp as a cause of ...
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In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions
... Abstract: P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from ...
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An in vitro evaluation of guanfacine as a substrate for P-glycoprotein
... Background: With a US Food and Drug Administration-labeled indication to treat attention-deficit/hyperactivity disorder (ADHD), the nonstimulant guanfacine has become the preferred α 2 -agonist for ADHD treatment. ...
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EFFECT OF PINEAPPLE (ANANAS COMOSUS) AND UZIZA (PIPER GUINEENSE) EXTRACTS ON FEXOFENADINE BIOAVAILABILITY: POSSIBLE ROLE OF P-GLYCOPROTEIN (P-GP) AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs)
... of P-glycoprotein-mediated cellular efflux while uziza extract reduced fexofenadine oral exposure by inhibition of organic anion transporting polypeptides (OATPs) during the intestinal absorption suggesting ...
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<p>Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells</p>
... A2780T cells, 0.1 μ M paclitaxel was added to the medium to maintain the resistance. The use of two cell lines in this study was approved by the Ethics Committee of the hos- pital (Union Hospital, Wuhan, China). ...
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CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination
... of P-gp in cells expressing P-gp alone at the ubiquitination permissive ...the P-gp band accumulated, indicating a role for ubiquitination in the P-gp stability of ...
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Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
... Therapeutic drug monitoring charts from 618 patients (256 men and 362 women) fulfilled the inclusion criteria. The study population included patients with a diagnosis of heart failure and/or atrial fibrillation. See ...
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P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling
... Most rats treated with IP injections of kainate displayed stage IV or V seizures (26 out of 32 rats, Table 1, Group A). Typically three kainate injections were needed, i.e. 20 mg/kg and SE was usually reached within 20 ...
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P glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
... f P-gp expression in HIV patients and particularly regarding the im portance o f the C3435T polym orphism as a predictor o f antiviral drug ...increased P-gp function. H owever ...
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Relationship between the expression of cyclooxygenase 2 and MDR1/P glycoprotein in invasive breast cancers and their prognostic significance
... Cycloxygenases (COXs) comprise a group of enzymes that participate in the conversion of arachidonic acid to prostaglan- dins [7]. COX-2 has been characterised as an unfavourable prognostic factor in numerous solid ...
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Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance
... a P-gp substrate, in humans (55). Beyond this, P-gp is apically expressed in liver and kidney epithelia, and on the blood side of brain capillary endothelial ...of P-gp, the ...
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Concomitance of P gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non Small Cell Lung Cancers
... Both P-glycoprotein (P-gp) and lung resis- tance-related protein (LRP) are drug transporters in cells, and the expression of these factors is often observed in cancers that have developed ...
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Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection
... Inhibition of P-glycoprotein (P-gp) efflux pumps Cells were first incubated with 100 mM verapamil for 1 hour at 37 ° C, 15,16 and then the transport experiment was performed with AmB [r] ...
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ATP-binding cassette (ABC) transporters in normal and pathological lung
... as P- glycoprotein (P-gp) and the multidrug resistance-associ- ated protein 1 (MRP1) were initially detected in tumour cell ...and P-gp expres- sion in the lung have especially ...
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Modulation of the P-Glycoproein-Mediated Intestinal Secretion of Glibenclamide: In Vitro and In Vivo Assessments
... the P-glycoprotein (P-gp) on the intestinal secretion of glibenclamide, a prototype of drug used to treat diabetic ...a P-gp modulator carbamazepine used at equimolar doses in ...
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Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells
... as P-glycoprotein (P-gp), encoded by the multidrug resistance 1 (MDR1) gene, and breast cancer resistance protein ...while P-gp expels both Hoechst and ...of P-gp ...
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Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index
... and P-glycoprotein (P-gp), the most important drug efflux pump and intracellular Rhodamine 123 accumulation indicated that the activity of P-gp was not inhibited by L1 and ...
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Original Article Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1)
... of P-glycoprotein is inhibited ...and P-glycoprotein have a synergic relationship in the pathogenesis of ...of P-glycoprotein may involve its pharmacological effects against ...
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Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
... Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that ...
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