P-gp (P-glycoprotein)
Concomitance of P gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non Small Cell Lung Cancers
... Both P-glycoprotein (P-gp) and lung resis- tance-related protein (LRP) are drug transporters in cells, and the expression of these factors is often observed in cancers that have developed ...
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EFFECT OF PINEAPPLE (ANANAS COMOSUS) AND UZIZA (PIPER GUINEENSE) EXTRACTS ON FEXOFENADINE BIOAVAILABILITY: POSSIBLE ROLE OF P-GLYCOPROTEIN (P-GP) AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs)
... of P-gp- mediated efflux during intestinal absorption over OATP while uziza juice reduced its exposure/bioavailability likely by preferential inhibition of OATP over ...
5
<p>Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells</p>
... intracellular P-gp in drug ...of P-gp from plasma membrane to intracellular organelles could be a potential way to overcome ...mitochondrial P-gp was involved in drug accumula- ...
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IMPROVING THE EFFICACY OF CYCLOPHOSPHAMIDE BY USING VERAPAMIL AS A P-GLYCOPROTEIN INHIBITOR IN BREAST CARCINOMA
... prevalence of breast cancer is increasing, and it is highlighted that the incidence rate will escalate further in the next 20 years in spite of current efforts to prevent the disease 11-13 . Risk factors involves in ...
5
An in vitro evaluation of guanfacine as a substrate for P-glycoprotein
... Background: With a US Food and Drug Administration-labeled indication to treat attention-deficit/hyperactivity disorder (ADHD), the nonstimulant guanfacine has become the preferred α 2 -agonist for ADHD treatment. ...
5
Versatile inhibitory effects of the flavonoid-derived PI3K/Akt inhibitor, LY294002, on ATP-binding cassette transporters that characterize stem cells
... as P-glycoprotein (P-gp), encoded by the multidrug resistance 1 (MDR1) gene, and breast cancer resistance protein ...while P-gp expels both Hoechst and ...of P-gp ...
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The Effect of the Dynamic Interplay of P-glycoprotein and Cytochrome P450 3A on the Portal Bioavailability of Dual Substrates
... of P-gp and Cyp3a/CYP3A, which are listed in Table ...of P-gp and CYP3A were represented as the regional distribution ratio in the gut relative to that present in the liver, as integrated by ...
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Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection
... Inhibition of P-glycoprotein (P-gp) efflux pumps Cells were first incubated with 100 mM verapamil for 1 hour at 37 ° C, 15,16 and then the transport experiment was performed with AmB [r] ...
10
CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination
... MCF-7/P- gp(+)/CD44s(+) or MCF-7/P-gp(-)/CD44(-) cells, with the highest p-value in three independent primary screens were considered as potential ...
14
ATP-binding cassette (ABC) transporters in normal and pathological lung
... as P- glycoprotein (P-gp) and the multidrug resistance-associ- ated protein 1 (MRP1) were initially detected in tumour cell ...and P-gp expres- sion in the lung have especially ...
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In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions
... Abstract: P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from ...
9
Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
... I P-gp inhibitors on S-digoxin levels compared with Class II P-gp inhibitors are the inhibitory concentrations for a certain drug in relation to the concentrations achieved in clinical ...for ...
7
Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index
... and P-glycoprotein (P-gp), the most important drug efflux pump and intracellular Rhodamine 123 accumulation indicated that the activity of P-gp was not inhibited by L1 and ...
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Relationship between the expression of cyclooxygenase 2 and MDR1/P glycoprotein in invasive breast cancers and their prognostic significance
... In each case, control reactions were included, in which spe- cific antibody was substituted by Primary Mouse Negative Control (DakoCytomation). Control reactions were also per- formed for each of the examined antigens. ...
9
Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance
... a P-gp substrate, in humans (55). Beyond this, P-gp is apically expressed in liver and kidney epithelia, and on the blood side of brain capillary endothelial ...of P-gp, the ...
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Modulation of the P-Glycoproein-Mediated Intestinal Secretion of Glibenclamide: In Vitro and In Vivo Assessments
... the P-glycoprotein (P-gp) on the intestinal secretion of glibenclamide, a prototype of drug used to treat diabetic ...a P-gp modulator carbamazepine used at equimolar doses in ...
5
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
... of P-gp in the efflux of the drug from the brain after BBB opening is not clear and could in principle be of limited importance once the NP/drug is deposited in the brain parenchyma and out of reach for the ...
10
Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... Cisplatin (CDDP), doxorubicin (DOX), penicil- lin, streptomycin, propidium iodide (PI), RNase A, Rho123 and Atractyloside glycoside (ATR) were purchased from the Sigma-Aldrich Chemical Co (St. Louis, MO, USA). ...
11
PLASMA GLYCOPROTEIN INHIBITORS AS A NEW TARGET FOR OPTIMAL DRUG DELIVERY
... Plasma glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP Binding Cassette (ABC) super family that functions specifically as carrier mediated primary active ...
8
Immunosuppressive drug interactions and resistance in mononuclear cells from renal transplant patients
... PSC P-gp patients FK506 following the addition of selective immunosuppressivc drug their regime had received treatment with either as part of is down-regulated function P-gp MDR1 be it t[r] ...
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