p-Hydroxyphenyl
Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells
... Epidemiological and genetic evidence has shown that an inflammatory process contributes to AD pathology. We have previously shown that there is a convincing link between neuro-inflammatory reactions and amyloido- ...
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DISCOVERY OF SOME EMERGING FREE RADICAL SCAVENGING CANDIDATES BEARING 2-(P-HYDROXYPHENYL)-4–(SUBSTITUTEDPHENYL)-1H-1,5–BENZODIAZEPINES PHARMACOPHORE
... A mixture of different 1-(p-hydroxyphenyl)-3- (substitutedphenyl) propane 1,3-dione derivatives (2.4 g; 0.01 mole) 5(a-j), o-phenylenediamine (1.08 g; 0.01 mole), and 20 mL ethanol with glacial acetic acid ...
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Phenytoin and its metabolite, 5-(p-Hydroxyphenyl-), 5-Phenylhydantoin, decrease supernatant levels of matrix-metalloproteases in the human macrophage : implications for drug-induced gingival overgrowth
... Phenytoin is metabolized in the liver via aromatic hydroxylation by the cytochrome P450 (CYP2C9 and CYP2C19) enzymes primarily to 5-(p-hydroxyphenyl-), 5- phenylhydantoin (HPPH). This may be further ...
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Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model
... Western blot analysis was performed with the hippo- campus or cortex dissected and stored at −80°C. The brain tissues were homogenized with lysis buffer (PRO- PREP; iNtRON, Sungnam, Korea; n = 8 mice per group) and ...
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Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite,5-(p-hydroxyphenyl-), 5-phenylhydantoin
... MMP-9 and TIMP-1 remained near control levels despite the potent proinflammatory challenge thus demonstrating the ability of these agents to alter macro- phage function. Compared to LPS alone, pretreatment with 50 μg/mL ...
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Specificity protein 1 is a novel target of 2, 4-bis (p-hydroxyphenyl)-2-butenal for the suppression of human oral squamous cell carcinoma cell growth
... Figure 3 The effect of HPB242 on specificity protein 1 (Sp1) protein expression in HN22 and HSC4 cells. HN22 and HSC4 cells were incubated with different concentrations of HPB242 for 48 hours. The cells were harvested ...
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Synergic effects of tryptamine and octopamine on ophiuroid luminescence (Echinodermata)
... Drugs In this study, we tested 3-[2-aminoethyl]indole tryptamine; Sigma, Bornem, Belgium and 1-[p-hydroxyphenyl]-2aminoethanol hydrochloride octopamine; Sigma on arm segments and on isol[r] ...
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1,1,1,3,3,3 Hexafluoro 2,2 bis(4 hydroxyphenyl)propane–benzene (2/3)
... In the course of our studies of the inclusion characteristics of host compounds containing geminal p-hydroxyphenyl groups (Toda et al., 1987; Kitamura et al., 1991; Bond & Toda, 1991), the ...
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Effects of Dobutamine on Left Ventricular Performance, Coronary Dynamics, and Distribution of Cardiac Output in Conscious Dogs
... The effects of dobutamine ([±]-4-[2-[[3-(p-hydroxyphenyl)-1-methyl propyl] amino] ethyl] pyrocatechol hydrochloride), a new synthetic cardioactive sympathomimetic amine, were examined on direct and ...
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Synthesis of Some New 1,3-Thiazolyldiphenyl Amine Derivative and Evaluation of their Antibacterial Effects
... o-hydroxyphenyl, p- methoxyphenyl, phenyl, p-hydroxyphenyl, p- aminodimethylphenyl Fur ther more, among azetidinone and thiazolidinone congeners, compounds having p-methoxyphenyl ...
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Preparation of anion-exchange resins from pine sulfuric acid lignin, one of the acid hydrolysis lignins
... of p-hydroxyphenyl unit and the guaiacyl unit in RHP-SAL and to obtain information on reaction conditions dur- ing the reaction with the epoxy reagent, 1-guaiacyl-1-p- hydroxyphenylethane (compound ...
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Study on Some Aryltellurium(IV) Complexes of 2,3-Bis (salicylideneamino)-Pyridine Schiff Base Sonu Chauhan 1, Deepak*1
... methoxyphenyl, p-ethoxyphenyl, p-hydroxyphenyl and 3-methyl-4-hydroxyphenyl) type complexes. The data predict the hexa coordination of tellurium atom by dibasic tetradentate –N, -N’, -O, and ...
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Reactivity of a condensed–type lignin model compound in the Mannich reaction and preparation of cationic surfactant from sulfuric acid lignin
... reactive p- hydroxyphenyl moiety is introduced at the side chain α -position instead of condensed-type aromatic ...investigations, P-SAL was converted to water-soluble lignosulfonate 4,5 ...
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Lignin characteristics of Abies beshanzuensis, a critically endangered tree species
... and P. pubescens lignin, while those peaks assigned to p-hydroxyphenyl propanones could not be detected from Cryptomeria japonica lignin ...and P. pubescens contain ...
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Factors limiting oxygen delignification of kraft pulp
... reactive p-hydroxyphenyl struc- ...delignification, p-hydroxyphenyl moieties, quantitative 13 C NMR, quantitative 31 P NMR, residual lignin, solubilized lignin, ...
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Agonist receptor efficacy II.pdf
... For example, it has been found that the two dopamine receptor agonists quinpirole and 3-(3-hydroxyphenyl)-N-n-propylpiperidine [(+)3-PPP] dem- onstrate reversed relative efficacies[r] ...
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Synthesis, crystal structure and Hirshfeld surface analysis of 4 [3 (4 hydroxyphenyl) 4,5 dihydro 1H pyrazol 5 yl] 2 methoxyphenol monohydrate
... In this article, we report the synthesis of a chalcone deri- vative by condensation of vanillin with p-hydroxyaceto- phenone and subsequent cyclization of this chalcone by reaction with hydrazine hydrate. ...
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The Synthesis and Evaluation of Vanillin Derivatives as the Fruit fly Attractant
... Some attractant compounds that have been studied, such as methyl eugenol (4-(4-Allyl-1. 2-dimetoxybenzena), cue lure (4-(4-Asetoxyphenyl)- 2-butanone) (Fig. 1a), and raspberry ketones ...
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PHYTOCONSTITUENTS PROFILE OF CLITORIA TERNATEA BY GC-MS AND ITS AGE-RELATED ANTICHOLINERGIC ACTIVITY AGAINST ALUMINUM AND RESTRAINT STRESS
... 7-hydroxy-2-(4- hydroxyphenyl); Cyclopentaneundecanoic acid, methyl ester; Phytol; Methyl Isostearate; 12-Methyl-E, E-2,13-Octadecadien-1-ol; Cyclopropaneoctanoic acid, 2-{[2 pentylcyclopropyllmethyl}, methyl ...
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Computational Studies on 2(2-Hydroxyphenyl)-N-phenyl Nitrone, Spectroscopic Investigation.
... The title compound 2(2-Hydroxyphenyl)-N-phenyl Nitrone (2HPNPN) was synthesized and characterized by FT-IR, FT-Raman spectral analysis. The molecular geometry, harmonic vibrational frequencies and bonding features ...
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