P-selectin (CD62)
The Relationship between Blood Pressure with P-Selectin in Indonesian Hypertension Patients
... hypertension. P-selectin plays an important role in the inflammatory response through the initiation of leukocyte adhesion in platelets and endothelial ...and P-selectin in Indonesian ...
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Role of P-Selectin in Patients with Slow Coronary Flow
... determine P selectin level in PCSF patients, the area under the curve (AUC) was ...of P selectin in detection of slow coronary flow was ...
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Absence of P selectin delays fatty streak formation in mice
... that P-selectin played a sig- nificant role in the formation of the fatty streak type lesions (8–20 wk on diet) and its importance declined when the lesion reached the fibrous plaque stage (37 wk on ...B). ...
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Monocyte tethering by P selectin regulates monocyte chemotactic protein 1 and tumor necrosis factor alpha secretion Signal integration and NF kappa B translocation
... In contrast, we found that tethering of PMNs to purified P-selectin, or to transfected cells that express P-selectin, allows rapid activation events inside-out signaling of /2 integrins,[r] ...
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Anti P selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear
... of P-selectin in PMN-mediated injury after reperfusion of the rabbit ...murine P-selectin mAbs, designated ...rabbit P-selectin and prevents histamine-induced leukocyte rolling, ...
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P selectin is a host receptor for Plasmodium MSP7 ligands
... Here, the identification and characterization of interac- tions occurring between human P-selectin and Plasmo- dium MSP7 proteins are described for the first time. Prior to this work, much of the existing ...
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P-selectin-mediated platelet adhesion promotes tumor growth
... of P-selectin-mediated platelet adhesion in solid tumors using the Rip1-Tag2 mouse model and xenograft tumor ...that P-selectin deficiency abolishes platelet deposition within solid ...that ...
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Sulfatide decreases the resistance to stress induced apoptosis and increases P selectin mediated adhesion: a two edged sword in breast cancer progression
... for P-selectin expressed by activated endothelial cells, and such interactions facili- tate the formation of aggregates, which in turn increase their metastatic potential ...a P-selectin ...
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ROLE OF P-SELECTIN IN PATIENTS WITH SLOW CORONARY FLOW
... In this study there was negative correlation between p selectin and LDL cholesterol this was in agreement with Chan et al. where they found incubation of HDL-C and oxidized LDL (ox-LDL) with platelets led ...
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C5a induced expression of P selectin in endothelial cells
... endothelial P-selectin, secretion of von Willebrand factor, and adhesiveness for human ...in P-selectin expression and adhesiveness of neutrophils were similar to the effects of histamine and ...
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P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in ApcMin/+ Mice
... endothelial P-selectin plays an important role in mediating leu- kocyte rolling on endothelial cells during inflamma- tion [8-10], the physiological and pathological roles of platelet ...
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Inflammatory roles of P selectin
... expressing P-selectin demonstrate an intracellular Ca2+ transient, functionally up-regulate beta-2-integrins (CD11/CD18 glycoproteins), become polarized in shape, and are primed for enhanced degranulation ...
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P selectin glycoprotein ligand 1–deficient mice have impaired leukocyte tethering to E selectin under flow
... µg/mouse), anti–murine P-selectin mAb RB40.34 (rat IgG1, 30 µ g/mouse), anti–murine L-selectin mAb Mel- 14 [rat IgG2a F(ab ′ )2 fragments, 30 µ g/mouse], or iso- type control rat monoclonal IgG1 (30 ...
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P selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P selectin in inflammation
... of P- selectin, the plasma form had a greater electrophoretic mobility than the platelet transmembrane form, sug- gesting that, indeed, plasma P-selectin is shed from the cell ...similar ...
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Activation of polymorphonuclear leukocytes reduces their adhesion to P selectin and causes redistribution of ligands for P selectin on their surfaces
... with P-selectin, or by other signaling ...to P-selectin, when compared to up-regulation of CD11/CD18 integrins, suggests that "bond trading" may occur as activated PMNs transmigrate in ...
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Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase
... E-selectin, P-selectin, VCAM1 or ICAM1 on the surface of ECs was not upregulated by treatment of HUVECs with HBSS or vWF (Figure 5) suggesting that upregula- tion of the adhesion molecules on the ...
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Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis
... soluble P-selectin (sP-selectin), platelet-derived microparticles (PDMPs), plasminogen activator inhibitor 1 (PAI-1), soluble E-selectin (sE-selectin), soluble vascular adhesion ...
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E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases
... (E-selectin, P-selectin glycoprotein ligand-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 (VCAM-1)) and six other known biomarkers (C-reactive protein (CRP), ...
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Selectin and selectin ligand binding: a bittersweet attraction
... neous lymphocyte-associated antigen (CLA), binds to all three selectins and appears to be an interesting drug tar- get. Its expression by T cells requires the action of multiple glycosyltrans- ferases such as core 2 β ...
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Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
... and P-selectin in skin, ET-1 in monocytes and skin fibroblasts, and monocyte chemoattractant molecule-1/CC chemokine ligand 2 in different cell types in the skin [51-53] (Table ...and ...
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