p-Smad2
High p Smad2 expression in stromal fibroblasts predicts poor survival in patients with clinical stage I to IIIA non small cell lung cancer
... investigated p- Smad2 expression in stromal fibroblasts and its prognos- tic significance in ...high p-Smad2 ex- pression in stromal ...nuclear p-Smad2 expression Table 2 ...
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Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
... creased p-CREB, while down-regulating p-Smad2/3 binding to CBP, which reduced activation of p-Smads in induced ...of p-CREB occurred chiefly in normal lung tissue, and expression was ...
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Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
... of p-Smad2/3 and Smad4 were increased in human colon cancer tissues (Figure ...1C). Smad2/3 is the most important signal transduction factor for the transport of TGF- β 1 signaling, which is ...
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<p>TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition</p>
... The SMAD proteins exhibit critical functions in metas- tasis formation and EMT. 41 Our results showed that the expression of SMAD7 was signi fi cantly reduced. There was no signi fi cant change in total SMAD2, ...
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The expression of TGF β1, Smad3, phospho Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
... human Smad2 (1:1000; Cell Signaling Technology, Boston, MA, USA), p-Smad2 (Ser465/467) (1:1000; Cell Signaling Technology, Boston, MA, USA), Smad3 (1:1000; Cell Signaling Technology, Boston, MA, ...
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Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients
... of p-Smad2 and p-Smad3 that was potently inhibited with galunisertib treatment at micromolar ...decreased p-Smad2/3 downstream TGF-β ...
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HGF upregulation contributes to angiogenesis in mice with keratinocyte specific Smad2 deletion
... of Smad2 and Smad3. Phosphorylated Smad2 (p-Smad2) and p-Smad3 bind the common Smad, Smad4, and the heteromeric complexes translocate into the nucleus to regulate transcription of TGF-β ...
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<p>Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo</p>
... (Smad2, p-Smad2, Smad3, p-Smad3 and TGF- β ) in BRL-3A cells was measured by Western ...(Smad2, p-Smad2, Smad3, p-Smad3 and TGF- β ) in BRL-3A cells was measured by ...
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Endothelial to mesenchymal transition drives atherosclerosis progression
... intermediary SMAD2 (p-SMAD2), and the appearance of EndMT markers col- lagen 1, vimentin, and SM22α (Supplemental Figure 1; see complete unedited blots in the supplemental material; supplemental ...
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Hydrogen Sulfide Alleviates Myocardial Collagen Remodeling in Association with Inhibition of TGF-β/Smad Signaling Pathway in Spontaneously Hypertensive Rats
... of p-Smad2 and p-Smad3 protein in CFs by Western blot. (A) p-Smad2 (Ser245/250/255) protein content in CFs of each group; B: p-Smad2 (Ser465/467) protein content in CFs of ...
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Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
... (SMA), p-Smad2, p-Smad3, p-p38, and ...α-SMA, p-Smad2, p-Smad3, and Smad4 in LX-2 ...of p-Smad2 and p-Smad3 in liver tissues were significantly ...
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<p>MicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition via TGFβ1/Smad2 signaling pathway in human bladder cancer</p>
... 1, Smad2 and p-Smad2 were increased in miR-132 downregulated BC ...between SMAD2 and miR-132 levels in BC tissues and the results consistent with theoretical ...Thus, Smad2 and ...
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Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation
... of p-Smad2/3 was remarkably increased in WT lungs, as well as in Opn KO lungs albeit to a sig- nificantly reduced extent when compared with WT, on days 7 and 28 post-exposure to MWCNTs; this result is in ...
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Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells
... The cultured DESCs were lysed using radioimmunopreci- pitation buffer, and total protein was obtained by centrifu- ging at 12,000 rpm for 15 min at 4 °C. Then, we used BCA Protein Assay kit (Pierce Biotechnology, ...
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Original Article MicroRNA-27a adjusts diabetic nephropathy patients and inhibits TGF-β/Smad signaling pathway
... such as connective tissue, liver, kidney, lung, brain, skin and muscle [20]. TGF-β is composed of secretory peptide TGF-β, bone morphogenet- ic proteins (BMPs), activins, inhibins and mul- lerian inhibitor substance. ...
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Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent
... Cells were grown in T75 flasks, serum starved for 24 hours, and then incubated with either 0.1% DMSO control, TRAM-34 (200 nM), ICA-17043 (100 nM) or Ca 2+ free media for 1 hour. Cells were detached with 0.1% ...
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Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP response elements
... of P-Mad is sufficient to engage the ...a P- Mad gradient about the A/P axis, and the activated and repressed targets control proliferation (Brinker) and the P-Mad gradient itself ...of ...
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Keratinocyte specific Smad2 ablation results in increased epithelial mesenchymal transition during skin cancer formation and progression
... cells, Smad2, -3, and -4 are involved in growth inhibi- tion (2), a major tumor suppressive effect of TGF-β, and epithelial- mesenchymal transition (EMT) (8, 9), an early and major tumor promoting effect of ...of ...
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<p>Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway</p>
... TGF- β belongs to transforming growth factor- β (TGF- β ) superfamily which contains many growth factors, growth differentiation factor (Growth and differentiation factors, GDFs) and bone morphogenetic proteins (BMPs). ...
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Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
... disease compared to patients with benign breast disease (P < 0.0001). Immunofluorescence analysis confirmed Nodal expression in a subpopulation of cells in the two human breast cancer lines studied. Nodal is ...
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