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p/sup +/-n-p/sup +/ structure

Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

<p>Solutol<sup>&reg;</sup>HS15+pluronicF127 and Solutol<sup>&reg;</sup>HS15+pluronicL61 mixed micelle systems for oral delivery of genistein</p>

... shell structure. 30 This structure consists of the drugs being physi- cally incorporated into the micelles ’ hydrophobic inner cores by means of hydrophobic interactions while retaining the basic ...

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Daily consumption of the collagen supplement Pure Gold Collagen&reg; reduces visible signs of aging

<p>Daily consumption of the collagen supplement Pure Gold Collagen<sup>&reg;</sup> reduces visible signs of aging</p>

... the structure of the dermal layer must be maintained because the dermis provides structural support to the epidermis, which carries the blood vessels and supplies the skin with important nutrients for its ...

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Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox&reg;) in the Management of Chronic Wounds

<p>Assessment of Acceptability and Ease of Use of Haemoglobin Spray (Granulox<sup>&reg;</sup>) in the Management of Chronic Wounds</p>

... The concept of topical oxygen application has been investi- gated for many years. There are several ways oxygen may penetrate through the skin, which has porous and nonporous regions. Oxygen is a small molecule and can ...

10

Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO&reg; and OTEMTO&reg; studies: a subgroup analysis by age

<p>Efficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO<sup>&reg;</sup> and OTEMTO<sup>&reg;</sup> studies: a subgroup analysis by age</p>

... years, n=749; 65 years to ,75 years, n=674; 75 years to ,85 years, n=186; $85 years, n=12) in OTEMTO and 5,162 patients (40 years to ,65 years, n=2,654; 65 years to ,75 years, ...

10

RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

<p>RNA m<sup>6</sup>A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway</p>

... attention. N 6 -methyladenosine (m 6 A), one of the most abundant and reversible modi fi cation on mes- senger RNA, was identi fi ed more than forty years ...

10

Combined Therapeutic Effects of 131I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer

<p>Combined Therapeutic Effects of <sup>131</sup>I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer</p>

... The morphology and size distribution of nanoparticles were detected through TEM and DLS. As shown in Figure 1A, the obtained Cet-PEG-PLA-5Fu- 131 I nanoparticles showed uni- form size distribution with spherical shape. ...

11

Addition Of A Sleeve To The Etanercept Autoinjector (Enbrel&reg; MyClic&reg;) Improves Ease Of Use In Patients With Rheumatoid Arthritis

<p>Addition Of A Sleeve To The Etanercept Autoinjector (Enbrel<sup>&reg;</sup> MyClic<sup>&reg;</sup>) Improves Ease Of Use In Patients With Rheumatoid Arthritis</p>

... Patients and methods: Twenty-four adult patients (16 female) with RA and varying degrees of manual dexterity impairment took part in this user study. Written informed consent was supplied by each patient prior to ...

8

XEN&reg; Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma

<p>XEN<sup>&reg;</sup> Gel Stent: A Comprehensive Review on Its Use as a Treatment Option for Refractory Glaucoma</p>

... μ N for Xen 140, 25 μ N for Xen 63 and 15 μ N for Xen 45, comparing to the 2000 μ N of silicone tube ...μ N for Xen 140, 100 μ N for Xen 63, 70 μ N for Xen ...(2.2 ...

28

An Immunoscore System Based On CD3+ And CD8+ Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma

<p>An Immunoscore System Based On CD3<sup>+</sup> And CD8<sup>+</sup> Infiltrating Lymphocytes Densities To Predict The Outcome Of Patients With Colorectal Adenocarcinoma</p>

... Different steps were taken: sections of 4 µm thickness were cut from paraf fi n tissue blocks and mounted on silanized slides. Antigen retrieval solution (10X concentrate, Novocastra, Leica), primary antibodies ...

11

PD-L1 in Lung Adenocarcinoma: Insights into the Role of 18F-FDG PET/CT

<p>PD-L1 in Lung Adenocarcinoma: Insights into the Role of <sup>18</sup>F-FDG PET/CT</p>

... Immunohistochemistry (IHC) staining was performed on 5- μ m thick formalin- fi xed, paraf fi n-embedded slides obtained from lung adenocarcinoma tissue. Antigen retrie- val was performed using EDTA buffer (pH 9.0) ...

11

Comparing radiopaque markers and 13C-labelled breath test in diabetic gastroparesis diagnostics

<p>Comparing radiopaque markers and <sup>13</sup>C-labelled breath test in diabetic gastroparesis diagnostics</p>

... Patients and methods: Forty- fi ve patients (30 women, 15 men) with diabetes mellitus types 1 or 2 (40, 5) and symptoms of gastroparesis were examined with ROM and GEBT. All were interviewed, fi lled out symptom ...

9

TearCare&reg; system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare&reg; treatment on subjects with dry eye disease

<p>TearCare<sup>&reg;</sup> system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare<sup>&reg;</sup> treatment on subjects with dry eye disease</p>

... the P-values were the result of separate tests of whether the mean difference = 0 for each follow-up time ...the P-values were from simple mixed-effects linear models (with no covariates) that allow for ...

10

P53 Mutant p53N236S Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway

<p>P53 Mutant p53<sup>N236S</sup> Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway</p>

... Our previous study showed that p53 S/S mice manifested to an early onset of sarcomas that metastasized to various organs, such as liver and lung. 15 We attempted to under- stand the phenotypes resulting from the p53S ...

9

IN.PACTTM AdmiralTM drug-coated balloons in peripheral artery disease: current perspectives

<p>IN.PACT<sup>TM</sup> Admiral<sup>TM</sup> drug-coated balloons in peripheral artery disease: current perspectives</p>

... DEEP trial, a total of 358 patients mostly with CLI were randomized to IN.PACT Amphirion DCB treatment group or BA treatment group. Coprimary efficacy outcomes were TLR and angiographic LLL at 12 months, and the primary ...

12

ClariVein&reg;, mechanochemical endovenous ablation: patient selection and perspective

<p>ClariVein<sup>&reg;</sup>, mechanochemical endovenous ablation: patient selection and perspective</p>

... In order to investigate the effectiveness of the MOCA on small saphenous vein insuf fi ciency. Boersma et al 22 conducted a prospective, non-controlled, observational study in which 55 SSV re fl ux patients were treated ...

8

Optimization of the Oertli CataRhex 3&reg; phacoemulsification machine

<p>Optimization of the Oertli CataRhex 3<sup>&reg;</sup> phacoemulsification machine</p>

... microchatter or bounce around the tip for several seconds before a proper vacuum seal is established to allow prompt emulsification. New mean values and SDs were thus recalculated to reduce noise in the data. For vacuum ...

7

Evaluating Nephrocheck&reg; as a Predictive Tool for Acute Kidney Injury

<p>Evaluating Nephrocheck<sup>&reg;</sup> as a Predictive Tool for Acute Kidney Injury</p>

... deceased donor. 23 were diagnosed with DGF. There were no differences in age, gender, causes of end-stage renal disease, ischemic time, or degree of HLA mismatch between the patients with early graft function and DGF. In ...

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Pretreatment detection of circulating and tissue CD133+&nbsp;CD44+ cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer

<p>Pretreatment detection of circulating and tissue CD133<sup>+&nbsp;</sup>CD44<sup>+</sup> cancer stem cells as a prognostic factor affecting the outcomes in Egyptian patients with colorectal cancer</p>

... Descriptive data in the form of mean, median, range, SD, and percentages were used. Mann–Whitney U-test was used to find a relation between two groups of ordinal variables, chi-squared test between ≥ 2 groups of ...

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Outcome Of MicroPulse&reg; Transscleral Photocoagulation In Different Types Of Glaucoma

<p>Outcome Of MicroPulse<sup>&reg;</sup> Transscleral Photocoagulation In Different Types Of Glaucoma</p>

... Results: A total of 71 eyes of 68 patients (39 males, 29 females) aged 60.0 years (13 – 89 years) were treated with µP-TSCPC. The most common diagnosis was neovascular glaucoma. The safety index of corrected distance ...

8

Comparison of head-mounted perimeter (imo&reg;) and Humphrey Field Analyzer

<p>Comparison of head-mounted perimeter (imo<sup>&reg;</sup>) and Humphrey Field Analyzer</p>

... criteria was met: a cluster of three contiguous points with P,0.05, one of which had P,0.01 on a pattern deviation probability plot; corrected PSD/PSD with P,0.05; or a glaucoma hemifield test ...

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