p21 and p27
LncRNA-ANCR regulates the cell growth of osteosarcoma by interacting with EZH2 and affecting the expression of p21 and p27
... Previous studies have showed that EZH2 was over- expressed in a variety of human cancers, which en- hanced tumorigenesis through various signaling pathways [23]. In our study, downregulation of lncRNA- ANCR decreased the ...
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P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice
... of P21 and P27 to promote cell cycle acceleration in seminal vesicle tumors leading to uncontrolled cell proliferation and tumor growth under the conditions of lacking WT P53 ...
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<em>Kelussia odoratissima</em> Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo
... of p21 and p27 proteins with 8-hydroxy-ar-turmerone treat- ments were further studied on MCF7 cells to determine the possible characteristics of ...of p21 and p27 after treatment with ...
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The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse
... and p27 (rabbit polyclonal an- tibodies) or normal rabbit serum for p15 and p21 (goat polyclonal antibodies) were added for 20 min at 37°C to prevent non-specific ...p15, p21, p27 and (1/100) ...
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<em>Ferulago angulata</em> activates intrinsic pathway of apoptosis in MCF-7 cells associated with G<sub>1</sub> cell cycle arrest via involvement of p21/p27
... To further examine the detailed pathways responsible for induced apoptosis by FALHE toward MCF-7 cells, screening of critical proteins that are involved in various pathways of apoptosis was carried out. As shown in ...
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CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27
... of p21 and p27 proteins in TPC1 and BCPAP cells, but no changes in the protein levels of cyc- lin A2, cyclin B1, cyclin D1, cyclin D2, cyclin D3, cyclin E1, cyclin E2, CDK2, CDK4, or CDK6 were ...of ...
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Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21 Cip1 and p27 Kip1
... Here we applied the Chou-Talalay Method of analysis [13] and found that HF-ATS combination exhibited synergistic anticancer effects in a variety of human cancer cell lines, and in a xenograft nude mice model. ...
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Drosophila Cdi4 is a p21/p27/p57-like cyclin-dependent kinase inhibitor with specificity for cyclin E complexes.
... the p21/p27/p57 class of Ckis, a portion of these proteins that is thought to contact Cdks and cyclins (Chen et ...of p21, for example, interacts with PCNA and inhibits PCNA-dependent DNA ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... target P21 Cip1 in PGG-exposed MCF-7 cells remains an interesting question for further ...of P21 Cip1 and P27 Kip1 expres- sion to be associated with the G 1 -arrest action of ...
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Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells
... We characterized the brominated alkaloid Isofistularin-3 (Iso-3), from the marine sponge Aplysina aerophoba, as a new DNA methyltransferase (DNMT)1 inhibitor. Docking analysis confirmed our in vitro DNMT inhibition data ...
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CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
... To clarify the detailed mechanisms underlying CF-induced cell apoptosis, we detected the expression of apoptosis re- lated proteins in CF-treated HCT-116 and MSTO-211cells by western blot assay for the indicated time ...
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MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells
... 19. Chiang KC, Yeh CN, Hsu JT, et al. MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and ...
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Single-cell RNA sequencing identifies TGF-β as a key regenerative cue following LPS-induced lung injury
... Since TGF-β signaling was specifically activated in the cell cycle arrest subpopulation and TGF-β induces G 1 arrest in other cell types (21), we hypothesized that TGF-β induces cell cycle arrest in proliferating AEC2s. ...
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Original Article Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer
... Abstract: Background: There is no reliable marker available for early detection, diagnostic confirmation, or disease prognosis available of prostate cancer (PCa). We aimed to evaluate the function of Cullin-1 and unravel ...
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PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer
... To know the tumor suppressive roles of PAPR6 in CRC cells, we used a full-length PARP6 (FL-PARP6) and C-terminal deletion mutant PARP6 (ΔC-PARP6). FL- PARP6 consists of 630 amino acids and the C-terminal region (residues ...
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The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells
... All reagents were analytical grade and purchased from Sigma Aldrich (Milano, Italy). RPMI, DMEM were pur- chased from Life Technologies (Carlsbad, CA) supple- mented with 10 % FBS (fetal bovine serum), 1 % penicillin, ...
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Original Article MiR-142-3p is a tumor promoter by directly targeting FOXO4 to promote gastric cancer cell growth and suppress cell apoptosis in gastric cancer
... tion of miR-142-3p inhibitor decreased the miR-142-3p level, comparing with the transfec- tion of control (Figure 2A). Then MTT assays were performed to detect the cell proliferation ability. Consistent with real time ...
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The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells <div><br /></div>
... p53, p21 Wafl/Cipl, p27 Kipl, cyclin B1, cyclin dependent kinase 1 (CDK1)/cell division cycle pro- tein 2 (CDC2), CDK2, the p53-upregulated modulator of apoptosis (PUMA), B-cell lymphoma 2 (Bcl-2), ...
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A selective microRNA based strategy inhibits restenosis while preserving endothelial function
... of p27, GFP (to evaluate transduction efficiency), and GAPDH (loading ...that p27 was highly overexpressed in VSMCs and ECs transduced with Ad-p27 (Figure ...of p27 after transduction with ...
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Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
... of P21 gene polymor- phisms with PE ...of P21/ TP53 gene and PE risk remains ...and P21 (rs1801270 and rs1059234) gene polymorphisms with the risk of PE de- ...placental P21-rs1801270, ...
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