p21WAF1/CIP1
Relationship of hypoxia inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer
... 9. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW: Overexpression of Hypoxia-inducible Factor 1{{alpha}} in Common Human Cancers and Their Metastases. Cancer ...
7
Cytoplasmic p21WAF1/CIP1 expression is correlated with HER 2/ neu in breast cancer and is an independent predictor of prognosis
... This influence prompted us to investigate HER-2 expression in a retrospective series of breast cancers with p21WAF1/CIP1 staining by immunohistochemistry and a further 4 years of patient[r] ...
8
Posttranscriptional stabilization underlies p53 independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells
... both p21WAF1/CIP1/SDI1 mRNA and protein expression due to enhanced mRNA ...effect. p21WAF1/CIP1/SDI1 is an immediate early gene since its upregulation occurred independently of de novo protein ...
8
Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells
... cell cycle arrest effects of SAHA and RG7388 on using MCF-7 and LNCaP cells.. The cytotoxicity, cell 29.[r] ...
18
Lp16-PSP, A Member of YjgF/YER057c/UK114 Protein Family Induces Apoptosis and p21WAF1/CIP1 Mediated G1 Cell Cycle Arrest in Human Acute Promyelocytic Leukemia (APL) HL-60 Cells
... acute promyeloid leukemia (HL-60 cells) as model cancer to further investigate the potential molecular.. 84.[r] ...
16
Study of promoter CpG island hypermethylation of cyclindependent kinase inhibitor gene p21waf1/cip1 on some breast carcinoma cell lines
... variety of human neoplastic cell lines (11, 12). For instance, histone deacetylation could be a good candidate to the gene inactivation, as has been shown in many solid tumors (13), because using histone deacetylase ...
6
Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proliferative vitreoretinopathy via inhibition CDK2 and cyclin E
... Western blot and RT-PCR analysis of total retinal lysates indicated that p21 expression was significantly increased both at the protein and mRNA levels in the gene treated group compared[r] ...
9
Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin induced acute renal failure
... Cisplatin injection resulted in increased amounts of the cell-cycle indicators BrdU incorporation and nuclear PCNA in kidney cells of both wild-type and p212/2 mice.. However, the relati[r] ...
7
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
... Results: LRRK2 phosphorylates threonine (Thr) at TXR sites in an in vitro kinase assay, and the T304 and T377 were identified as putative phosphorylated residues. An increase of phospho-Thr in the p53 TXR motif was ...
15
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
... event suppressed p53 activity. These results support the in vivo findings that integrin avb3 ligation specifically influences the functional activity of p53. Importantly, regulation of p53 was independent of cell shape ...
9
Primitive hematopoietic cells resist HIV 1 infection via p21Waf1/Cip1/Sdi1
... mechanism by which the cyclin-dependent kinase inhibitor (CKI) p21 Waf1/Cip1/Sdi1 (p21), a known regulator of stem cell pool size, restricts HIV-1 infection of primitive hematopoietic cells. Modifying p21 ...
10
By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer
... In p21-+/+ MEF cells, Flag-MORC2 showed significant decrease in the percentage of G1 phase, and significant increase in the percentage of S phase compared with vector control Figure5b, l[r] ...
10
Semi purified extracts of Commelina benghalensis (Commelinaceae) induce apoptosis and cell cycle arrest in Jurkat T cells
... Since our results demonstrated an up-regulation in the protein expression levels of p21Waf1/Cip1, which led to the arrest of cell cycle in the G1/S interphase, it was essential to invest[r] ...
13
Original Article Mefloquine inhibits chondrocytic proliferation by arresting cell cycle in G2/M phase
... inhibitor, p21WAF1/ CIP1 in ...promotes p21WAF1/CIP1 expression thereby inhibits cell cycle ...The p21WAF1/CIP1 sup- presses the expression of cell cycle regulatory proteins, ...
6
Original Article Immunohistochemical expression of RUNX3 and p21 WAF1/CIP1 and its correlation with clinicopathologic parameters in breast carcinoma of Egyptian women
... Expression of p21waf1 and its relationship with clinicopathological parameters In normal breast tissue adjacent to the tumor, p21waf1 expression showed no detectable expression in non-di[r] ...
12
Csanadi, Endy (2012): Charakterisierung des bHLH-Transkriptionsfaktors ITF-2B. Dissertation, LMU München: Medizinische Fakultät
... DLD1 Cip1-Zellen pro Zellkulturschale (10 cm) in DMEM High Glucose mit 10% FCS ...p21 Cip1; die Zellen, denen kein Tetrazyklin zugegeben wurde, exprimieren p21 ...
106
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells <div><br /></div>
... Abstract: Danusertib (Danu) is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor ...
36
Evaluation of Tomato Genetic Resources for Response to Water Deficit
... To deeper understand the involvement of the sequenced genes in the drought tolerance response, expression data of asr2, tas14, tsw12, erd15 and cip1 were also inferred from a microarray [r] ...
15
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins.
... From these data, we conclude that the major effect of AAV2 infection on primary human fibroblasts appears to be upregulation of p21WAF1 gene expression and thus cell cycle arrest by the [r] ...
8
Skin Hyperproliferation and Susceptibility to Chemical Carcinogenesis in Transgenic Mice Expressing E6 and E7 of Human Papillomavirus Type 38
... Immunohistochemical staining for the cell cycle inhibitor p21WAF1 showed that in non-Tg mice, UV irradiation leads to accumulation of this protein in skin keratinocytes, but no accumulat[r] ...
10