P2Y receptors
Purinergic P2Y Receptors Are Involved in Xenopus Head Formation
... P2Y receptors belong to the family of G protein-coupled receptors and are ac- tivated by nucleotides in the extracellular ...that P2Y recep- tors might be involved in distinguishing between ...
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Drug like antagonists of P2Y receptors — from lead identification to drug development
... for P2Y receptor subtypes, as many of the reported modulators still lack the potency and selectivity for viable chemical drug-like ...for P2Y receptor antagonists lays in the antithrombotic area, where ...
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Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study
... and P2Y, which activates the intracellular ...the P2Y receptor ...the P2Y receptor system was sufficient to promote lung ...of P2Y receptors, P2Y 2 and P2Y 4 are the most ...
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Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery
... the P2Y 6 receptor being the receptor through which UTP and UDP activated I Cl,Ca in the present ...rat P2Y 6 receptor is, however, needed to substantiate this ...the P2Y 2 , P2Y 4 and ...
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New Insights in Purinergic Therapy: Novel Antagonists for UTP-Activated P2Y Receptors from Natural Products
... these P2Y receptors are associated with certain diseases such as cystic fibrosis, dry eye disease, Alzheimer, and cancer ...these P2Y receptors, especially P2Y2, in order to treat these ...
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Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells
... It has been recognized that neurotransmitters might play distinct, regulatory roles in ovarian physiology; for exam- ple, it has been proposed that, in addition to the regula- tory actions of gonadotropins, the activity ...
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Identification of targeting signals in human P2Y receptors in polarized MDCK(II) epithelial cells
... these receptors achieve a polarized distribution in epithelial ...for P2Y receptors and begin to unravel the mystery as to how this large family travels to either the apical or basolateral ...
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Important roles of P2Y receptors in the inflammation and cancer of digestive system
... Purinoceptors P2Y are widely distributed in human digestive system and different subtypes of P2Y receptors mediate different physiological functions from metabolism, proliferation, differentiation to ...
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Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3 kinase within the semicircular canal duct epithelium
... The present study augments previous reports of ion transport systems that are expressed and characterized in SCCD epithelium, including sodium absorption and chloride secretion. We showed here that sodium absorp- tion ...
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Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and their Roles in Extracellular Nucleotide Regulation of Cell Functions.
... P1 receptors (Carroll et ...and P2Y receptors and ecto-nucleotidases in MSC, particularly in osteogenic differentiation (Cavaliere et ...and P2Y receptors and their roles in mediating ...
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Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes
... P2 receptors during granulocytic and monocytic differenti- ation of HL-60 ...P2 receptors in differentiation into myelocytes has been confirmed in hematopoietic stem cells [17, 22, ...among P2Y ...
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purinergic receptor regulates steroid synthesis and proliferation of ovarian luteal cells
... Nucleotide receptors, also known as P2 recep- tors, together with P1 receptor subfamily, form the purinergic receptor family ...P2 receptors consist of two classes of purinergic ...P2X receptors ...
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Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
... Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and ...of P2Y receptors ...
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P2Y<sub>12 </sub>and P2Y<sub>13</sub> receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia
... both P2Y 12 and P2Y 13 receptors are involved in this ...cells, P2Y 13 knockdown reduced lipopolysaccharide (LPS)- induced IL-6 production, but by < 50%, which also implies that P2Y ...
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Activation of spinal dorsal horn P2Y<sub>13</sub> receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain
... polyuria. Control rats received the same volume/kg of ip citrate buffer. Body weights of the rats in the STZ-diabetic group were substantially lower than those in the normal control group (Figure 1, 2 weeks: P<0.05; 4 ...
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Novel agents for anti-platelet therapy
... The first GP IIb/IIIa receptor antagonist used in clini- cal settings is abciximab. This drug is the fragment of recombinant human-mouse chimeric monoclonal anti- body, which can inhibit GP IIb/IIIa receptors in a ...
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Ticagrelor: An investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome
... In the pivotal clinical trials, ticagrelor, a new potent oral direct-acting P2Y 12 inhibitor, demonstrated substantial benefits against clopidogrel, and thus providing a new solution in the care of patients with ...
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Uridine Triphosphate Thio-analogues Inhibit Platelet P2Y12 Receptors and Aggregation
... 23 Kim, H.S.; Ravi, R.G.; Marquez, V.E.; Maddileti, S.; Wihlborg, A.K.; Erlinge, D.; Malmsjo, M.; Boyer, J.L.; Harden, T.K.; Jacobson, K.A.: Methanocarba modification of uracil and adenine nucleotides: high potency of ...
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G PROTEIN COUPLED RECEPTORS A POTENTIAL NEW DRUG TARGET TO COMBAT DIABETIC SYNDROME: AN OVERVIEW
... GPR40: Fatty acids serve vital functions as sources of energy, building materials for cellular structures, modulators of physiological responses, and in some cases, biomarkers for disease. Recent reports have identified ...
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Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?
... A possible limitation of our study may be the use of the first quartile in a relatively small sample of normal popu- lation as a discriminator for low responders. Conse- quently, our results must be viewed only as a ...
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