p38/MAPK
Role of Regulatory Elements and the MAPK/ERK or p38 MAPK Pathways for Activation of Human Cytomegalovirus Gene Expression
... The MAPK signal transduction cascade consists of a three-component module consisting of MAPK, MAPK ki- nase (MEK, MAPKK, or MKK), and MAPK kinase kinase (MEKK, MAPKKK, or MKKK), which is ...
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Extracellular pH changes activate the p38 MAPK signalling pathway in the amphibian heart
... is p38-MAPK dependent (Gaitanaki et ...of p38-MAPK ...the p38-MAPK-specific inhibitor SB203580 ...from p38-MAPK to MAPKAPK2 to HSP27, which might be protective for ...
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Differential roles of p38 MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
... in transmitting and converting stress stimuli into apoptotic signaling (Bossy-Wetzel et al., 1997; Faris et al., 1998), while activation of the p38-MAPK r MAPKAPK2 (MAPK-activated protein kinase 2) r ...
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Hyperosmotic and thermal stresses activate p38 MAPK in the perfused amphibian heart
... on p38-MAPK activation. Hyperthermia (42 °C) induced p38-MAPK activation in an immediate (maximum at 30 s), sustained (over 30 min) and considerable (approximately ...of p38-MAPK ...
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Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
... AMPK/p38 MAPK-ERK3/mTORC1 ...the p38 MAPK activation status and the expression of ERK3 are valuable for evaluating the sensitivity of ICC to metformin and ...
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p38 MAPK inhibition reduces diabetes-induced impairment of wound healing
... of p38 activation appears to be critical during wound healing in db/db ...of p38 phosphorylation in neutrophils and macrophages was associated with significant improvements in wound healing, SCIO-469 may ...
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p38 MAPK is a likely component of the signal transduction pathway triggering rapid cold hardening in the flesh fly Sarcophaga crassipalpis
... Developmentally, p38 MAPK activation is most robust in life stages where the RCH response is most pronounced, ...phospho-p38 MAPK activation in flies reared at 25 than at 20°C ...period ...
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Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines
... of p38 MAPK induced by advanced glyca- tion end products in cultured human umbilical vein endothelial cells, and similar results were also found in LPS-stimulated murine dendritic cells [30, ...that ...
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Nuclear Localization of p38 MAPK in Response to DNA Damage
... of p38 MAPK was detected in DN3 thymocytes from RAG1 deficient mice compared with that in wild type DN3 thymocytes (Fig 5B and ...showed p38 MAPK in the nucleus (Fig ...endogenous p38 ...
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The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
... In addition to causing the local release of ligands, pressure overload may also activate intrinsic “stretch” receptors in cardiomyocytes. Leading candidates for cardiac stretch receptors include the integrin family of ...
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Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans
... (16). The function of NF-κB is regulated to a large extent by a family of proteins named inhibitors of NF-κB (IκBs). In the cytoplasm of quiescent cells, IκBs are bound to NF-κB, ensuring its inac- tive state. Activation ...
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Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
... Cells were pretreated with the p38 MAPK inhibitor SB203580 (10 μM) for 1 h prior to stimulation with recombinant mouse leptin (6 nM or 60 nM) for 24 h. Total RNA was prepared from cardiomyocytes using ...
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p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease
... that p38 MAPK cascade has a critical impact on microglial activation and ...response. P38 MAPK together with CD200-CD200R signalling can moderate microglial dynamics in PD ...and p38 ...
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The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
... of p38 MAPK phosphorylation associated with Aβ plaques and NFTs [71] and that mutant tau (P301L) becomes mislocated to the somatodendritic compartments of the neuron compared to healthy neurons where tau is ...
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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
... the p38 MAPK pathway is required for normal skeletogenesis in mice, as mice with deletion of any of the MAPK pathway member–encoding genes MAPK kinase 3 (Mkk3), Mkk6, p38a, or p38b displayed ...
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HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism
... activates p38 MAPK phosphorylation, which in turn facilitates HBV replication during early infection; however, HBV subsequently induces HoxA10 production, which in turn represses HBV replication during late ...
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Regulation of dematin by the p38 MAPK and the adaptor protein 14 3 3
... 114 phosphorylated. The number of sites detected varies with species and cell type, and so sites have to be validated on an individual basis. Detection of the same peptide can also be inconsistent. We have demonstrated ...
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Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
... (ROS) are involved in Andro-induced C6 cell death. Never- theless, there was no ROS generation in this study. The incon- sistency may be due to different tumor types (Figure S1). It has become clear that the p53 protein ...
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Chondrocyte response to growth factors is modulated by p38 mitogen activated protein kinase inhibition
... which p38 MAPK inhibition restores prolif- eration in IL-1-activated/stressed human chondrocytes may thus be different from those described for lapine prepara- tions (current studies) or for bovine ...
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The Critical Role of p38 MAP Kinase in T Cell HIV-1 Replication
... cation in primary human T lymphocytes infected with the LAI strain, and observed that CNI- 1493 mediated suppression of p38 MAPK activation. ~~~e _ a_*', -[r] ...
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