p38 MAPK inhibitor
Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells
... The anti-inflammatory effects of budesonide and AZD7624 were assessed on cytokine release from lipopolysaccharide-stimulated alveolar macrophages and peripheral blood mono- nuclear cell[r] ...
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ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... and p38 mitogen-activated protein kinase (p38 ...JNK inhibitor (SP600125) significantly reduced ZnO NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or ...
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Anti-diabetic drug, metformin, and the p38 inhibitor (SB203580) reduces internal organs oxidative stress in non-obese type 2 diabetic rats
... activate p38 mitogen-activated protein kinase (p38 MAPK), and aggravate complications via the enhancement of reactive oxygen species (ROS) ...or p38 MAPK inhibitors could reduce ROS ...
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Extracellular pH changes activate the p38 MAPK signalling pathway in the amphibian heart
... the p38-MAPK activation. However, SB203580, the specific p38-MAPK inhibitor, did not affect the increase in HSP70 protein levels induced by alkalosis ...was p38-MAPK ...
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Strong inhibition of TNF α production and inhibition of IL 8 and COX 2 mRNA expression in monocyte derived macrophages by RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor
... of MAPK cascades through the LPS receptor (CD14) or Toll-like receptors ...The p38 MAPK inhibitor RWJ 67657 (4-[4-(4-fluorophe- nyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3- ...
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Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans
... by MAPK inhibition (31), suggesting that activated MAPKs could play a role in the Pro33 regulation of ...of MAPK signaling in the enhancement of SERT activity by incubating SERT/Leu33 and SERT/Pro33 cells ...
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Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
... Cells were pretreated with the p38 MAPK inhibitor SB203580 (10 μM) for 1 h prior to stimulation with recombinant mouse leptin (6 nM or 60 nM) for 24 h. Total RNA was prepared from cardiomyocytes ...
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Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
... (ERK) MAPk cascade, but not that of p38 MAPk. A specific p38 MAPk inhibitor (SK&F 86002) blocked superoxide anion production in response to FMLP and reduced adhesion and ...
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Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs
... PKA, p38 MAPK, and PI3K in a cAMP-dependent man- ner [16] and of ERK1/2 via the SRC/RAS-dependent path- way ...each inhibitor of PKA, p38 MAPK, PI3K or ERK1/2 suppressed the expression ...
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RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium
... To determine the role of RAGE on barrier function of RPE after Aβ treatment, we measured transepithelial resistance (TER) in RPE for 48 h. The mean initial TER of controls was 46±4.5 ohms·cm2 when they reached a plateau. ...
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Nuclear Localization of p38 MAPK in Response to DNA Damage
... enabling p38 MAPK to interact with a nuclear shuttling chaperone to mediate its re-localization to the ...dnp38 MAPK further support the effect of a conformational ...of p38 MAPK in ...
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Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
... of p38 MAPK induced by ATO, and this activity was partially dependent on AMPK ...of p38 MAPK by SB203580 or specific short interfering RNA (siRNA) promoted the inactivation of mTORC1 in ICC ...
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Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes
... the p38 mitogen- activated protein kinase (MAPK)-specific inhibitor SB ...the p38 MAPK pathway only in 4pX-1 cells. pX-mediated Stat3 and p38 MAPK activation is Ca 2ⴙ and ...
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p38 MAPK is a likely component of the signal transduction pathway triggering rapid cold hardening in the flesh fly Sarcophaga crassipalpis
... The p38 MAPK cDNA was amplified using degenerate PCR primers p38-1 (GTNAAYGARGAYTGYGA) and p38-2 (TGRTYRTARTGCATCCARTT) (where Y=T or C; R=A or G; N=A, C, G or T) using Platinum Taq DNA ...
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Original Article Renoprotective effect of total glucosides of paeony in STZ-induced diabetic rats: role of thioredoxin-interacting protein
... (p-p38 MAPK) were assessed by immunohistochemistry, western blot analysis and/or real-time polymerase chain reaction ...p-p38 MAPK protein determined by immunohistochemistry and/or Western ...
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Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava
... the MAPK, Akt, and PTEN proteins appears differ in the diabetic vena cava possibly resulting in a net protective effect against pressure induced apoptosis-related signal- ...in MAPK- or Akt-related ...
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The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation
... The novel Aurora kinase A inhibitor TC-A2317 also causes defects in the mitotic spindle, abnormal centrosome, prolonged mitotic duration, aneuploidy, apoptosis, autophagy, and senescence. In comparison with ...
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Purinergic P2Y14 receptor modulates stress induced hematopoietic stem/progenitor cell senescence
... hypophosphorylated Rb and was inhibited by treatment with a ROS scavenger or inhibition of p38/MAPK and JNK. Treatment of WT cells with pertussis toxin recapitulated the P2Y 14 phenotype, suggesting that ...
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Enhancement of fibrinogen-triggered pro-coagulant activation of monocytes in vitro by matrix metalloproteinase-9
... For the coagulation experiments, monocytes were incubated with the particular reagent for 4 h under con- tinuous rotation to prevent monocyte adhesion. After washing 200 μL of re-calcified human plasma was added to the ...
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Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
... in p38 MAPK-mediated cell survival? We already described above that p38 MAPK can indirectly regulate survival by promoting the expression of survival secreted fac- tors such as ...that ...
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