P450 aromatase
P450 aromatase: a key enzyme in the spermatogenesis of the Italian wall lizard, Podarcis sicula
... by P450 aromatase, and, once produced, they work by their nuclear and cell surface receptors (Carreau et ...2011). P450 aromatase is an enzymatic complex, composed of two proteins, a ...
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Significant correlation between high motility and P450- aromatase expression in human spermatozoa - an immunochemistry based study
... and aromatase P450 expression in human ...the P450- aromatase enzyme with washed seminal slides was carried out and the results correlated with spermatozoon motility evaluation ...of ...
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Induced synthesis of P450 aromatase and 17β estradiol by d aspartate in frog brain
... of P450 aromatase, brains (N3) were rapidly immersed in Bouin’s fluid (Sigma-Aldrich, Milan, Italy) and then embedded in paraffin; serial sections (10m thick) were incubated in 1% normal goat serum ...
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P450 aromatase expression in the temperature sensitive sexual differentiation of salamander (Hynobius retardatus) gonads
... Hynobius P450 aromatase (P450arom) cDNA was isolated from adult gonads and the partial nucleotide or deduced amino acid sequences were determined, showing a high level of identity with various vertebrate ...
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Mise en évidence des transcrits du cytochrome P450 aromatase dans les spermatozoïdes humains éjaculés
... Des souris d6ficientes en aromatase (souris ArKO) pr6sentent une spermatogen6se alt6r6e avec une diminution du nombre de sperma- tides rondes et allong6es et des spermatoz[r] ...
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The effect of seminal plasma β-NGF on follicular fluid hormone concentration and gene expression of steroidogenic enzymes in llama granulosa cells
... CYP19A1/P450 aromatase transcript in llamas submitted to mating or given GnRH or purified β-NGF in the present study sug- gesting a plausible switch of the steroidogenic pathways towards a ...
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Breeding Biotechnology, Sex Determination, and Growth in Southern Flounder, Paralichthys lethostigma
... Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in th[r] ...
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Mise au point Estrogènes et reproduction chez le mâle
... : Localisation of cytochrome P450 aromatase and oestrogen receptors c~ and 13 in bank vole testicular cells.. : Effect oftes- tosterone and estradiol in a man with aromatase[r] ...
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The Role of Aromatase and Castration on Spatial Learning and Memory Changes by Nandrolone
... The androgenic receptor is not necessarily the only mechanism of action for ND in the Central Nervous Sys- tem (CNS). ND can also be converted to estrogen through oxidation and the subsequent elimination of methyl groups ...
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Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions
... that P450 aromatase, which converts androgens to estrogens, was exclusively expressed in stromal cells, although not all serum estrogens are pro- duced in functioning stroma ...of P450 ...
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Aromatase inhibitors in men: effects and therapeutic options
... with aromatase deficiency. Aromatase is the enzyme responsible for conversion of androgens to ...gynecomastia. Aromatase inhibitors were proven to be safe, convenient and effective for the treat- ...
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Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
... Given that exon 1d was used in a significantly larger propor- tion of elderly tissues than the tissues of the control group regardless of whether the tissue was cancerous or normal, the utilization of exon 1d seems to be ...
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Bone loss and the aromatase inhibitors
... Very recently, the preliminary results of a study comparing adjuvant exemestane with placebo in low-risk breast cancer patients were presented by Lonning et al (2004). At 24 months, CTX had increased from baseline by 35% ...
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Bioluminescent Cytochrome P450 Assays
... of P450-Glo™ assays has certain fundamental advantages over fluorescent ...the P450-Glo™ luminogenic substrates compared to typical fluorescent substrates, so little or no organic solvent is introduced with ...
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1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells
... for aromatase protein detection. The level of aromatase (denoted by Arom) expression was estimated by densitometric analyses after normalization with the β -actin signal (n = 5 – 6 in each ...
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Role of Aromatase Inhibitor in Endometriosis
... to aromatase inhibitor during pregnancy could have a serious impact on the fetal ...of aromatase inhibitor reported, a retrospective study had been performed to investigate the fetal outcome of infertility ...
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Identification of reliable reference genes for quantitative real-time PCR normalization in pitaya
... To the best of our knowledge, this study is the first report on systematically evaluating the expression sta- bility of different potential reference genes for qRT-PCR in the Cactaceae family. Thirty-nine typical ...
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Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy
... CYP enzymes are central to Phase I drug metabolism and are involved in the biotransformation of over 75% of all drugs (Guengerich, 2008). CYP enzymes are organized into families and subfamilies based on similarity in ...
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Obesity and male breast cancer: Provocative parallels?
... It is pertinent at this juncture to bring to light the connection between cholesterol and its oxysterol metab- olite 27-hydroxycholesterol (27HC) in the context of obesity. 27HC is a recognised selective ER modulator ...
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Critical appraisal of denosumab in the treatment and prevention of postmenopausal osteoporosis and bone loss in patients undergoing hormone ablation
... Denosumab and treatment-induced bone loss with aromatase-inhibitor therapy Aromatase-inhibitor therapy for hormone-sensitive breast cancer rapidly increases bone resorption and dec[r] ...
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