P450 Enzymes
Original Article Expression of cytochrome P450 enzymes and drug transporters is unaffected by the bioactive compound cyasterone from Cyathula officinalis Kuan
... cytochrome P450 enzymes (CYP450s) and drug transporter expression were ...cytochrome P450 enzymes and drug transporters were determined in HepG2 cells and mouse liver tissue using qRT-PCR and ...
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Engineering and Characterization of Cytochrome P450 Enzymes for Nitrogen Atom Transfer Reactions
... Cytochrome P450 enzymes are most commonly associated with the hydroxylation and dealkylation of xenobiotic molecules in mammals, and in this case the substrate scope is ...involve P450-mediated ...
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INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN
... cytochrome P450 isoenzymes which are present in the liver: these may be induced or ...Other enzymes such as alcohol dehydrogenase, xanthine oxidase and monoamine oxidase may also be involved, and simple ...
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Homology modeling of mosquito cytochrome P450 enzymes involved in pyrethroid metabolism: insights into differences in substrate selectivity
... these P450 enzymes and the predictions based on our docking studies are consistent with experimental results of pyrethroid metabolism mediated by these three ...among P450 enzymes in insects ...
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CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae
... elevated P450 enzyme expression as associated with bendiocarb resistance, most notably genes from the CYP6 ...CYP6 P450 expression, which also provides resistance across contrasting ...
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Identification and functional analysis of two P450 enzymes of Gossypium hirsutum involved in DMNT and TMTT biosynthesis
... The homoterpenes (3E)-4,8-dimethyl-1,3,7-nonatriene (DMNT) and (E,E)-4,8,12-trimethyl- 1,3,7,11-tridecatetraene (TMTT) are major herbivore-induced plant volatiles that can attract predatory or parasitic arthropods to ...
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Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro
... CYP enzymes in both the liver and extrahepatic tissues such as the intestine, plays an important role in the oxidation of xenobiotics and contributes to the biotransformation of about 60 % of currently used ...
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Olefin Cyclopropanation and Carbon Hydrogen Amination via Carbene and Nitrene Transfers Catalyzed by Engineered Cytochrome P450 Enzymes
... Designing new synthetic pathways into microbial hosts demands careful consideration of redox balance, ATP balance, product toxicity, feedback inhibition, and host selection, the last factor accounting for growth rate and ...
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Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease
... Autoimmune polyendocrine syndrome type I (APS I) and idiopathic Addison's disease are both disorders with adrenal insufficiency but with differences in genetic background, clinical presentation, and extent of ...
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Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation
... cytochrome P450 (CYP) superfamily plays a pivotal role in both detoxification and activation of ...metabolizing enzymes, and tissue-specific expres- sion of CYPs, in vivo studies could provide relevant ...
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Erythropoietin and Chronic Kidney Disease Alter Hepatic Expression of Cytochrome P450 Enzymes and Drug Transport Proteins
... that leads to decreased expression of target genes. We could not demonstrate direct phosphorylated STAT5 inhibition of CYP3A; therefore, it is likely that STAT5 is acting indirectly or, possibly, EPO is signaling through ...
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Human bone marrow niche chemoprotection mediated by cytochrome p450 enzymes
... 57 enzymes that catalyze the oxidation of various organic substrates, from intermediary steps in cholesterol metabolism to drugs and other chemicals ...Most enzymes displayed comparable mRNA levels in ...
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Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway
... All steroid hormones are produced from cholesterol [35]. The abnormal production of steroid hormones, for example, the hypercortisolemia seen in the Cushing´s syndrome, is a life-threatening condition [36, 37]. The ...
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Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450 dependent enzymes
... a P450-dependent mitochondrial ...mitochondrial P450- dependent enzyme. Adrenal malate dehydrogenase, a non-P450-dependent mitochondrial enzyme was not inhibited while renal 24-hydroxylase, a ...
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Hepatoprotective Diterpenoids Isolated from Andrographis paniculata
... cytochrome P450 enzymes (CYPs) are known as a superfamily of haemoproteins with a unique spectrophotometric absorbance peak at 450 nm when re- duced by a reducing agent and bound by carbon monox- ide ...
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VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1
... Cytochrome P450 2E1 (CYP2E1): Cytochrome P450 is a superfamily of enzymes involved in monooxygenation of both endogenous and exogenous substrates including endogenous fatty acids and acetaminophen, ...
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Genomic insight into neonicotinoid sensitivity in the solitary bee Osmia bicornis
... these enzymes with potentially serious implications in relation to their capac- ity to metabolise certain ...a P450 within the CYP9BU subfamily, with recent shared ancestry to the Apidae CYP9Q subfamily, ...
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Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury
... biotransformation enzymes, especially cytochrome P450 enzymes (CYPs), compared to those of primary hepa- tocytes ...metabolizing enzymes and compar- ably transport drugs when compared to those ...
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Comparison of Amino Acid Sequences of Halloween Genes in Spodoptera litura and Spodoptera littoralis
... five P450 enzymes involved in the last four steps of ecdysteroid biosynthe- sis from ketodiol to 20E namely Spook (Spo), Phantom (Phm), Disembodied (Dib), Shadow (Sad) and Shade (Shd) related to ecdysteroid ...
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EFFECTS OF CURCUMIN ANALOGUE, 2, 6-BIS (2, 5-DIMETHOXYBENZYLIDENE) CYCLOHEXANONE (BDMC33) ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN CULTURED CACO-2 CELL MODEL
... The results of this study have demonstrated that activities of CPR in treated Caco-2 cells treated with curcumin were increased, but not affected significantly compared to that of the untreated group. Likewise, in Caco-2 ...
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