p50/p65
Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Interacting with p65/RelA and p50/NF-κB1
... or p65-mediated activation of NF- B-Luc pro- moter activity, implying that ICP0 might act at or downstream of the p50/p65 ...with p65 or p50 to inhibit NF-B promoter ...with ...
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Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters.
... the p50 precursor, p105 (54), sug- gesting instead that the initial increase in NF- k B occurs through the disruption of the NF- k B–I k B ...and p65, in human foreskin fibroblasts during HCMV infection has ...
10
Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters.
... (the p65 promoter [60, 65] and pHSCAT (the p105/p50 promoter [12, 65]), were described ...the p65 promoter deletion constructs (p65F1CAT, p65F3CAT, p65F5CAT, and p65F6CAT [this construct also ...
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PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up Regulating the PKCα/NF κB Pathway
... Materials and Methods: The esophageal carcinoma cell lines Eca109 and EC9706 and normal esophageal epithelial cell line HEEC were cultured. The expression of PLCE1, protein kinase C alpha (PKCα), and nuclear factor kappa ...
7
Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2 - implications for a combinatorial treatment
... NF-κB2, p65, c-Rel and RelB) which dimerize into hetero- and homo-dimeric complexes and are held in the cytoplasm by the inhibitors of NF-κBs (IκBs) ...of p50/p65 and c-rel/ p65 in the nucleus ...
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A MT1-MMP/NF-κB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells
... NF-κB p65 (TGGAGCTTCC) was found in the 5'-flanking region of the human MT1-MMP gene [48] and NF-κB-mediated induction of MT1-MMP was con- firmed in murine melanoma cells [49] and in human fib- rosarcoma cells ...
10
PubMedCentral-PMC5270671.pdf
... inhibits p65/p50 dimers) that keep NF-κB inactive in the ...are p50/p65 heterodimers which are ubiquitously expressed in mammalian tissue [11, 15-17], consistent with the highest level of ...
20
Regulation of Inducible Nitric Oxide Synthase Expression by Viral A238L-Mediated Inhibition of p65/RelA Acetylation and p300 Transactivation
... displaces p65 and p300 from the distal NF- B-spe- cific DNA sequence in the iNOS ...p300, p65, and p50 were present to similar extents in whole nuclear extracts from either Raw-pcDNA or Raw- A238L ...
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IκBζ: an emerging player in cancer
... with p50/p50 and p50/p65 ...the p50 subunits of these complexes and its association with the p65 subunit has to date exclusively been detected after overexpression of both ...
13
NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression
... the p65/p50 heterodimer and p50/p50 homodimer of the canonical NF-κB that directly binds to the TNFα and FAS promoters, respectively, to activate their ...
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p21 mediates macrophage reprogramming through regulation of p50 p50 NF κB and IFN β
... active p65-p50 and inhibitory p50-p50 NF-κB ...the p50-p50 homodimer in LPS-primed and -rechallenged macrophages, impairing their ability to attenuate IFN-β production and ...
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Organ specific roles for transcription factor NF κB in reovirus induced apoptosis and disease
... containing p50 and p65/RelA ...of p50-null mice following reovirus ...of p50 was associated with massive reovirus- induced apoptosis and uncontrolled reovirus replication in the ...not ...
11
Original Article MicroRNA-146a regulates cisplatin-resistance of non-small cell lung cancer cells by targeting NF-κB pathway
... IRAK1, p50, p-p65, p65 in normal DDP-resistant cells were determined by western blot ...and p50 were up-regulated in A549/DDP and Calu-1/DDP cells compared to parental cells, and phosphoryla- ...
9
MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65
... of p65 possesses two match sites to the miR- 690 seed region. p65, a subunit of NF-κB, which can function either as a homodimer or as a classical het- erodimer with the p50 subunit of NF-κB ...
14
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
... Major downstream mediators of FcgR activation are the NF- B class of transcription factors, which are important for the regulation of immune and inflamma- tory responses [19]. They are homo- or heterodimers composed of ...
12
Follicular Dendritic Cells and Human Immunodeficiency Virus Type 1 Transcription in CD4+ T Cells
... We reasoned that if FDC-produced TNF-␣ were responsible for the observed increased HIV transcription, then an increased level of activated i.e., nuclear NF-B p50 and p65 would be presen[r] ...
9
Original Article lncRNA-cox2 enhance the intracellular killing ability against mycobacterial tuberculosis via up-regulating macrophage M1 polarization/nitric oxide production
... NF-κB p50 subunit. Previous report have elucidated that p50 lacks a tran- scription activation ...bound p50- p50 as a homodimer to iNOS gene promoters, it blocks binding of active ...
9
Inhibition of the NF-κB Pathway by Varicella-Zoster Virus In Vitro and in Human Epidermal Cells In Vivo
... of p50 and p65 associated with VZV infection con- trasted with the well-documented early and sustained nuclear translocation of NF- B proteins in HSV-infected cells, which we confirmed in parallel ...
12
Westinghouse_P50_computer.pdf
... Using the probe, load the X-Register with the starting location of binary loader (X7602) i depress the start button.. Put machine In Run mode; depress the Master Clear bu[r] ...
936
Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
... in means were significant in 35 of these studies. They identified 46 studies suitable for analysis of P300 measures, including 1,443 patients and 1,251 controls. There were 20 P50 studies, including 421 patients ...
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