p53 degradation
p53 Degradation Activity, Expression, and Subcellular Localization of E6 Proteins from 29 Human Papillomavirus Genotypes
... that p53 degradation efficiency is related to the expression of E6, we measured the levels of the 29 HPV E6 proteins through their fusion with ...and p53 degradation ac- tivity (Table ...
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
... wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor ...activating p53 in ...the p53 activators, which identi fi es DHODH as a frequent target for structurally ...
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Proteasome Activator REGγ Enhances Coxsackieviral Infection by Facilitating p53 Degradation
... (i) p53 neg- atively regulates CVB3 replication, (ii) REG ␥ promotes CVB3 replication, at least in part, through facilitation of p53 degra- dation, and (iii) CVB3 infection enhances REG ␥ sumoylation, which ...
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Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.
... induced p53 degradation in vitro but not in vivo at early ...induce p53 degradation. In vitro degradation reactions were performed at 25, 30, and 37 8 C ...induced p53 ...
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CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
... stabilizing p53 and suppressed cell viability, colony formation, migration and invasion in cervical cancer HeLa and breast cancer MCF7 cells with wild-type p53 (wtp53), whereas CCDC106 overexpression ...
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Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells
... the p53 tumor suppressor protein through interaction with ...E6-AP, p53, and E6BP in ...binding, p53 binding, and p53 degradation ...to p53 and that E6 binding to p53 is ...
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Genetic Analysis of High-Risk E6 in Episomal Maintenance of Human Papillomavirus Genomes in Primary Human Keratinocytes
... E6-mediated p53 degradation was necessary for persistent HPV genome replication was not an- ...for p53 degradation in cultured cells, another explanation was more ...for p53 ...
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An RNA aptamer targets the PDZ-binding motif of the HPV16 E6 oncoprotein.
... We have described an RNA aptamer to HPV16 E6 that inhibits the interaction between E6 and the PDZ1 domain from Magi-1. This molecule (F2) is also the most apoptotic of the aptamers in SiHa cells, however, appears to have ...
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Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice
... of p53 has been observed in the hepatocytes of individuals with fibrotic liver diseases, but the significance of this is not ...linked p53 activation in hepatocytes to liver ...promotes p53 ...
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The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.
... To determine whether the ability of E6 to interact with p53 leads to a disruption of cell cycle control, mutated E6 proteins were tested for p53 binding and p53 degradation targeting in [r] ...
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Regulation of p53: a collaboration between Mdm2 and MdmX
... inhibits p53, as discussed above, Mdm2 and MdmX also have independent roles in the regulation of ...inhibit p53 transcriptional activity by interfering with the ability of p53 to interact with the ...
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Review Article New insights into regulation of p53 protein degradation
... for p53, including Pirh2, COP1, TRIM24, ARF-BP1, CA- RP1/2, TOPORS, Synoviolin, CHIP, JFK, MKRN1, E4orf6, E1B55K and BZLF1 [21], these Mdm2- independent ubiquitination proteasome path- ways also are involved in ...
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Peptide Interactions Stabilize and Restructure Human Papillomavirus Type 16 E6 To Interact with p53
... as p53. It is unclear if this is due to an unmasking of an intact p53-interacting site on 16E6 upon binding LXXLL or if the interaction of 16E6 with LXXLL peptides causes a de novo p53 interaction ...
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hAda3 Degradation by Papillomavirus Type 16 E6 Correlates with Abrogation of the p14ARF-p53 Pathway and Efficient Immortalization of Human Mammary Epithelial Cells
... and p53 degradation-defec- tive E6 mutants maintain the expression of p14ARF but select for the proteosomal degradation of the p53 ...for p53 and HDM2 ...
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High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.
... to p53, specifically to the C terminus, but that event has no perceptible effect on degra- ...the p53 core, and the binding is associated with ...of p53, but an intact 16E6 molecule is required for ...
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Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes.
... The results of these experiments indicate that i the half-life of newly synthesized p53 is relatively long 4 h in early-passage human keratinocytes and fibroblasts but short in keratinoc[r] ...
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Human Papillomavirus E6 Regulates the Cytoskeleton Dynamics of Keratinocytes through Targeted Degradation of p53
... the p53 tumor suppressor protein, resulting in ubiquitin-mediated degradation of p53 by the proteasome (7, 8, ...vivo degradation of p53 requires sequences at the amino termi- nus of E6 ...
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Addressing intra-tumoral heterogeneity and therapy resistance
... or p53 pathways, can confer cancer cells with different sensitivities to targeted therapy [11, 12], chemotherapy [13], and radiation [12], suggesting heterogeneity of cancer cells with these mutations could ...
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Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins.
... Since the HPV-16 E6-promoted degradation involves the ubiquitin-dependent proteolysis pathway, specific mutations were made in the amino terminus of p53 to examine whether the E6 targete[r] ...
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Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation
... We further characterized the regulation of ETS2 by showing that the COP1/DET1 ubiquitin ligase complex is important for the degradation of ETS2 by CDK10. In addition, we demonstrated that DET1 cannot bind an ETS2 ...
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