P53 Expression
Histopathological Analysis and P53 Expression in Intestinal Tumors.
... elevated p53 and the presence of DNA aneuploidy, a factor that correlated with poor ...evaluating p53 expression may prove helpful in determining various biological subgroups of colorectal ...with ...
135
P53 Expression in Acute Myeloid Leukemia in Sudanese Patients Using Flow Cytometry
... that p53 was expressed in all types of acute myeloid leukemia and observed in 31 of 50(62%) patient’s samples this indicate that P53 mutation plays a role in ...of p53 expression showed low ...
9
Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Binds to p53 and Represses p53-Dependent Transcription and Apoptosis
... vIRF1 associates with p53 in vivo. Because vIRF1 causes transformation and inhibits tumor necrosis factor-mediated apoptosis, we investigated whether vIRF1 interacts with p53. By using the calcium phosphate ...
6
<p>microRNA-519d Induces Autophagy and Apoptosis of Human Hepatocellular Carcinoma Cells Through Activation of the AMPK Signaling Pathway via Rab10</p>
... Bcl-2 expression, as well as increased Bax, Beclin1, Atg5 and p53 expression, the extent of AMPK phosphoryla- tion as well as the ratio of ...
14
Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism
... of p53 as a tumour suppressor in renal cell carcinoma (RCC) is unclear, our recent analysis suggests that increased wild-type p53 protein expression is associated with poor ...that p53 ...
29
The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms
... of p53 transactivation. Inhibition of TBP expression in cells suggests a mechanism by which BZLF1 could repress p53 tran- scriptional function in spite of also inducing multiple post- translational ...
10
Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate
... c-Myc expression, which in turn enhanced ribosome biogenesis, resulting in a reduced availability of ribosomal protein to bind Mdm2, thus increasing the Mdm2-mediated digestion of ...of p53 ...
16
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
... the p53 status on the extrinsic apoptosis cascade activated by death inducing ligands like TRAIL is much more ...of p53 on extrin- sic apoptosis induction and the distribution of the three phenotypes was ...
10
p53/Surviving Ratio as a Parameter for Chemotherapy Induction Response in Children with Acute Myeloid Leukemia
... of p53 after their chemotherapy. How- ever, the p53 expression had increased but not signifi- cantly because one subject had decreased levels of p53 after the induction phase ...repaired, ...
7
The expression and significance of IDH1 and p53 in osteosarcoma
... high p53 expression in osteosar- coma biopsies, which is accordance with our result in osteosarcoma cell lines MG63 and ...of p53 mutation in human glioblastoma. Accumulation of func- tional ...
10
mdm2 mRNA Level is a Prognostic Factor in Soft Tissue Sarcoma
... protein expression was detected by West- ern blots analysis and normalized to actin ex- ...four P53 expression groups divided into zero, mod- est, marked or strong expression was ...lost ...
10
Predicting Adjuvant Chemotherapy Outcome by Simultaneous Analysis of Thymidylate Synthase Expression and p53 Nuclear Accumulation in Colorectal Cancer
... suppressor p53 is one of the most frequently mutated genes in human CRC [15] ...mutated p53 protein has a great stability, a significantly longer half-life and accumulated in tumor cells thus could be ...
9
Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles
... the p53 protein, and in contrary, tumor 9 exhib- ited an increase in glucose and lactate concentration, which is probably caused by the mutation in the DNA binding domain of the p53 ...of p53. In ...
10
Download Download PDF
... in p53 expression, which was in line with a poor ...of p53 in the progression of HCCs. In conclusion, overexpression of p53 was in line with extra large and poorly differentiated ...
5
Download Download PDF
... mutant p53 expres- sion in HM cell culture showed a significant differ- ence at each treatment dose of 17 β estradiol (p = ...the expression of mutant p53 in HM cell culture become higher after being ...
6
TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo
... TSPAN12 expression, which is frequently upregulated in NSCLC, is inversely correlated with p53 ...the expression levels of TSPAN12 were also increased in three human NSCLC cell lines compared to ...
9
Mutant p53 induces EZH2 expression and promotes epithelial– mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing
... miR-26a expression, while re-expression of p68 rescued miR-26a expression (Figure 3G, P = ...with p53-null HEC- 50 EC cells (supplementary figure ...inactive p53 mutants (C135Y, R175H, ...
15
Characterisation of PP2Cβ in regulating tumour suppressor pathways in cancer cell lines : A thesis presented to Massey University in partial fulfilment of the requirement for the degree of Masters in Genetics
... 12 p53 in response to DNA damage ...wild-type p53 induced phosphatase (Wip1 or PP2Cδ) is a transcriptional target of p53 [99] and forms an autoregulatory loop with p53, by dephosphorylating ...
117
Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway
... HCC cell lines HepG2 (carrying wild-type p53) and Hep3B (p53 deficient) were purchased from American Type Culture Collection (Manassas, VA, USA). The cells were maintained in Dulbecco’s Modified Eagle’s ...
9
Multi stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation
... The oncogenic events during Friend erythroleukemia Although SFFV is an acutely transforming retrovirus, it induces malignant transformation of erythroid cells by a mechanism of insertional mutagenesis which is usually ...
11