P53 gene
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis.
... The p53 gene is a classic tumor suppressor gene, known as the guardian of the genome that regulates cell cycle and consequently cellular ...The gene is located in the locus ...named p53 ...
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Mutations of the p53 Gene in Gliomas from Malay Patients
... Mutations of the p53 Gene in Gliomas from Malay Patients ORIGINAL ARTICLE Mutations of the p53 Gene in Gliomas From Malay Patients AJafri, PhD*, MY Aziz, BS**, S Ros, BS**, I Nizam, phD** "Neuroscienc[.] ...
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Alterations of the p53 gene in nasopharyngeal carcinoma.
... SSCP analysis of exon 8 revealed mutation in DU145, a prostate carcinoma cell line passaged in nude mice, and in two cell lines established from NPC, CNE-1 and CNE-2, also passaged in nu[r] ...
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Wild-Type p53 Enhances Efficiency of Simian Virus 40 Large-T-Antigen-Induced Cellular Transformation
... in p53 gene status (p53 ⴙ / ⴙ versus p53 ⴚ / ⴚ ) with simian virus 40 (SV40) revealed a quantitatively and qualitatively decreased transformation efficiency in p53 ⴚ / ⴚ cells compared ...
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Sirtuin 1: A Target for Kidney Diseases
... by p53 path- ways ...a p53 apoptotic pathway, which was preceded by the increase in albuminuria ...(53). P53 was upregulated and activated in the renal cortex of db/db mice and streptozotocin ...
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Nardilysin controls intestinal tumorigenesis through HDAC1/p53–dependent transcriptional regulation
... wild-type p53. Gene knockdown of NRDC in HCT116 cells enhanced the expression of the apoptotic markers, p53 and p21, which were induced by treatment with 5-fluorouracil (5-FU) and oxaliplatin ...
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... The p53 tumor suppressor gene is the most study gene for prognosis and prediction of chemotherapy respond of ovarian cancer patient, but the prognos- tic value of p53 in ovarian cancer is ...
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Comprehensive review of fetal adenocarcinoma of the lung
... contained p53 gene mutations, while all the PB they studied contained missense mutations in exons 5, 7, and ...study, p53 mutations are statistically more frequent in PB than in ...of p53 ...
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RECQ1 expression is upregulated in response to DNA damage and in a p53 dependent manner
... and p53 mutations are by far the most common in human cancer, including breast ...mutant p53 (p53R280K) that confers a “gain of function” including chemotherapy resistance, metabolic deregulation, and ...
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MUCOXIN ENHANCED TRANSCRIPTION AND PROTEIN EXPRESSION OF P53 IN BREAST CANCER CELL LINE T47D
... the p53 gene encoding the p53 protein. p53 is a tumor suppressor that acts as a trans- cription factor from genes involved in the cell cycle and apoptotic checkpoint phase in cancer ...causes ...
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Effects of elements on the cancer suppressing gene p53
... the p53 gene is damaged, tumor suppression is severely ...of p53 will most likely develop tumours in early adulthood, a disease known as Li-Fraumeni ...syndrome. p53 can also be damaged in ...
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Role of spirulina platensis on mitomycin c induced genotoxicity in ehrlich ascites carcinoma bearing albino mice: single cell gel electrophoresis (comet assay) and semiquantitative rt pcr analysis
... mRNA gene expression which accompanied with down-regulation the gene expression of apoptotic genes that is in turn succeeded to inhibit DNA damage and decreased the percentage of DNA ...of p53 ...
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
... a p53-dependent manner and DNA double- strand breaks (DSB) are repaired by non-homologous end joining (NHEJ) ...the p53 gene is mutated in 30–50% (p53-mut) of glioblastomas ...intact ...
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The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia
... investigated for alterations in a variety of proto-oncogenes which have been implicated in the evolution of CML from its chronic phase to blast crisis. The most common genetic change found in the evolution of typical Ph1 ...
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The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity
... of p53 to activate ...of p53 is its DNA sequence-specific transcriptional activation of target ...influence p53 function, a human cell line carrying a mutated p53 gene (C33A) was ...
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Mutational Analysis of KRAS, BRAF, and TP53 Genes of Ovarian Serous Carcinomas in Korean Women
... Mutation of the TP53 gene is the most common mutation in human cancers.16 It has been suggested that p53 protein alterations due to missense mutations and loss of the p53 protein by nons[r] ...
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Translational control mechanisms in the p53 response network
... . For YBX1, numbers above the immunoreactive bands represent the relative amount of proteins normalized against both the reference protein and the mock condition (set to 1 separately for each cell line). (f) Ectopic ...
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XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53 DRAM pathway
... p62, p53 and DRAM antibody were provided by Santa Cruz Biotechnologies (Santa Cruz, CA, USA); chemi- cals such as dimethyl sulphoxide (DMSO) and other reagents were also obtained from Sigma; XingNaoJing injection ...
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Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.
... To determine whether p53 can influence the growth of normal human genital epithelial cells, wild-type and mutant p53 genes were cotransfected with the neomycin resistance gene into early[r] ...
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Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation
... Published gene sets of rhabdomyosarcomas and other pediatric malignancies were used in this analysis [19, ...between gene expression profiles of the mosaic mouse tumors described above and gene ...
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