P53 Mutation
Widely dispersed p53 mutation in respiratory epithelium A novel mechanism for field carcinogenesis
... point mutation in p53 codon 245, a codon which is frequently mutated in lung cancer ...widespread p53 mutation in the tra- cheobronchial tree was verified by repetitive testing at all sites, ...
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Original Article Immunohistochemistry of p53 and Ki-67 and p53 mutation analysis in renal epithelioid angiomyolipoma
... of p53 and Ki-67 by immunohistochemistry (IHC) and investigated p53 mutation analysis in 11 cases of EAML in comparison to classical ...Methods: P53 and Ki-67 expression status were determined ...
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The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report
... Background: Metastatic breast tumors from other organs are very rare. We herein describe the case of a patient with a metastatic breast tumor due to ovarian cancer who was diagnosed by the succession of a p53 ...
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Functional repair of p53 mutation in colorectal cancer cells using trans-splicing
... mutant p53 transcripts in cancer cells, we transfected p53- PTM (Figure 1A) and the controls (Figure S1) into two colorectal cancer cell lines (HT-29 and SW620) carrying p53 mutation in codon ...
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The prognostic value of p53 mutation in pediatric marrow hypoplasia
... of p53 mutation in the BM, a good concordance between p53 mutation gene expression and FA was ...of p53 gene mutation which could explain the tendency of those patients to ...
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Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection
... of p53 in patients with ...found p53 mutants in 33 of 105 cases of gastric cancer and Domek et al [17] worked with the hypothesis that tumorigenesis involves deregulation of cell proliferation and ...
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GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner
... and p53 with different mutational status. GTSE1 regu- lates p53 function to promote breast cancer progression mainly by the following three ...type p53 was restrained by oncogene GTSE1 via ...
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Novel pattern of P53 mutation in breast cancers from Austrian women
... Since mutagens produce an extraordinary diversity of mutational patterns, differential mutational exposures among populations are expected to produce different patterns of mutation. Classical epidemiological ...
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The impact of the MYB-NFIB fusion proto-oncogene in vivo
... Recurrent fusion of the v-myb avian myelobastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) generates the MYB-NFIB transcription factor, which has been detected in a high percentage of individuals with ...
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The effect of p53 gene mutational status, EGFR expression and proliferative potential on clinical outcome in patients with astrocytic glial tumours
... the p53 gene in several tumour types are present in a non- random fashion, suggesting that some mutant forms produce a growth advantage in the cells in which they ...the p53 missense mutations occur in the ...
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Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland
... carcinomas, p53 mutations were identified and subsequently characterized by DNA ...the p53 gene, in both the more and the less differentiated area of this tumor, clearly showed that the p53 ...
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
... (144/08-ek). P53 mutation status of primary cells and cell lines was determined by sequen- cing (Ion AmpliSeq Cancer Hotspot Panel v2, Thermo Fisher Scientific) in the core unit for DNA technologies, ...
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Targeting p53 by small molecules in hematological malignancies
... other anti-cancer agents to achieve better anti-tumor activity than alone. For example, ex vivo experiments using patient tumor samples have shown that nutlin synergizes with doxorubicin, chlorambucil, and fludarabine in ...
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Malignant epithelioid angiomyolipoma of the kidney with pulmonary metastases and p53 gene mutation
... Although p53 mutation has been described in one case report of renal EAML by Kawaguchi et ...significant p53 mutation was found in two other cases reported by Ma et ...nuclear p53 ...
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An investigation of genetic alterations in gastric and colorectal cancer
... detect p53 protein. Because of its short half-life, wild-type p53 protein does not normally accumulate in amounts so that it can be detected by ...the p53 protein, increasing its half-life. Therefore ...
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Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
... and p53 function lose-driven lung cancer cells in vitro and in vivo, pharmacologically targeting HK2 may be explored as an effective therapy for ...(Kras mutation and p53 deletion) and human H23 cell ...
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Absence of hereditary p53 mutations in 10 familial leukemia pedigrees
... Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not ...The p53 gene was examined by single-strand conformation polymorphism ...
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Prognostic value of <em>p53</em> mutation for poor outcome of Asian primary liver cancer patients: evidence from a cohort study and meta-analysis of 988 patients
... Chi-square test was used to assess the significance of the associations between p53 mutation and clinical features. Cumulative survival was tested by the Kaplan–Meier method, and the Mantel–Cox model was ...
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors
... the p53 status, as cells with p53 mutation were more resistant to treatment with RO- ...the p53 status on inhibitor efficiency could be confirmed in p53 knock down cells (Figure ...of ...
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Case Report Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors
... point mutation was observed in the duode- num ...point mutation was not observed in the normal duodenum sample, one possibility is that the codon 12 mutation induced the adenocarcinoma to develop ...
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