P53 pathway
The RP-Mdm2-p53 Pathway and Tumorigenesis
... a p53-dependent checkpoint in response to a broad range of oncogenic insults including elevated expression of c-Myc, E2F1, Ras, E1A, and v-Abl ...a p53-dependent checkpoint in response to deregulated ...
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Original Article Association of RNF43 with cell cycle proteins involved in p53 pathway
... Abstract: Our previous study has demonstrated that RNF43 could regulate the cell cycle in a p53-dependent man- ner in HCC. In this study, we aimed to access whether RNF43 could interact with cell cycle proteins ...
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Reactivation of the p53 pathway as a treatment modality for KSHV induced lymphomas
... the p53 pathway using murine double minute 2 (MDM2) inhibitor Nutlin-3a conveyed specific and highly potent activation of PEL cell ...both p53 and MDM2 and that the MDM2 inhibitor ...
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Regulation and function of mitochondrial Hep27 : a novel modulator of the Mdm2-p53 pathway
... wild-type p53 tumors ...assess p53 functional status, we applied a gene signature capable of predicting non-functional p53 (p53 mutation signature) (203) to the Miller dataset and found the ...
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Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down regulation of the host p53 pathway
... Using a nylon microarray, we recently characterized common gene expression changes induced during the infection of human lung epithelial cells by five different influenza A viruses. This shared signature was exploited to ...
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The p53 pathway in breast cancer
... Perhaps surprisingly, relatively few studies have investigated the status of these genes in human cancer in general, and in breast cancer specifically. One such gene of particular inter- est is σ , which was originally ...
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Original Article Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma
... the p53 pathway or the Rb pathway or both, thus, the latter two pathways are obligatory for progression of ESCCs with mir-577/TSGA10 axis ...interactive pathway in regulating cancer cell ...
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Original Article KIAA0101 up-regulates SERPINE-1 expression in p53 signalling pathway in gastric cancer
... the p53 pathway regulation by KIAA0101 in the development of gastric cancer remains to be ...the p53 signalling ...the p53 signalling pathway could be an unknown mechanism related to ...
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Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer
... transition of the mitotic cell cycle, the p53 signaling path- way, and so on. DLGAP5 was significantly related to the p53 pathway. After we knocked out DLGAP5 in Capan-2 and SW1990 cells, the protein ...
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<p>Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway</p>
... showed that p53 transiently sensitized cells to Fas-induced apoptosis by inducing Fas-FADD binding. 44 Ang2 is a growth factor belonging to the angiopoietins and is involved in endothelial physiology and ...
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Role of Wnt-p53-Nox Signaling Pathway in Cancer Development and Progression
... of p53 function are frequently found to be coupled in ...development pathway. Genetic aberration in any component of this pathway such as APC, β-catenin, receptor results in uncontrolled cell ...
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Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells
... of p53, P27, and P21 could be adjusted by midazolam, suggesting that midazolam could manage cell cycle through the regulation of p53 pathway to induce apoptosis in MA-10 ...
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Apoptosis inducers in chronic lymphocytic leukemia
... the p53 pathway, the mechanisms involved have still not been unambiguously ...are p53 targets) but also the p53- independent Bim ...on p53, Noxa can also be regulated independently of ...
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A p53 independent role of Mdm2 in estrogen mediated activation of breast cancer cell proliferation
... the p53-pathway in estrogen receptor positive breast cancer cells then the conven- tional chemotherapeutics that rely on the p53 tumor suppressor, a major cell death regulator [31], may not activate ...
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Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications
... and p53 expressions in 98 human breast carcino- mas are summarized in Table ...and p53 were diffusely ex- pressed in 56 cases ...and p53 was predominantly detected in the nuclei ...
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Network analysis reveals potential markers for pediatric adrenocortical carcinoma
... analysis. Pathway enrichment analysis demonstrated that cell cycle, terpenoid backbone biosynthesis, and oocyte meiosis were overrepresented amid upregulated ...
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A systems level approach to understanding transcriptional regulation by p53 during mammalian hibernation
... as p53 and NF-κB move in and out of the nucleus during the torpor cycle (Fleck and Carey, 2005; Allan and Storey, ...nuclear p53 protein concentration was significantly reduced by 4-fold in torpid ground ...
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Characterization of the tumor suppressor capabilities of SWI_SNF complex member BAF155 in cancer cell lines and cooperation of SNF5 and p53 pathways
... the p53 tumor suppressor protein (Vousden, 2002). Once stabilized, the p53 protein may induce apoptosis if the damage is deemed ...of p53 directly, per se. As mentioned previously, upon DNA damage, ...
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Chk’ing p53 deficient breast cancers
... with p53 deficiency ...of p53-deficient cancers. As p53 is mutated or otherwise inactivated in many human malignancies, ATR/Chk1 inhibitors may indeed find their place as a substantial ther- apeutic ...
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<p>P53 Mutant p53<sup>N236S</sup> Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway</p>
... in p53 S/S ...Stat3 pathway dependent, we treated p53 S/S MEF with ...the p53 S/S MEF (Figure 4C). Moreover, p53 S/S MEF-induced H1299 migration and invasion were clearly inhibited by ...
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