P53 tumor suppressor factor
Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor
... of p53, including the growth suppression SH3B domain, the central core DNA binding domain, and the tetramerization ...alters p53 protein stability (39), vIRF does not appear to alter its ...targets ...
11
LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway
... a tumor suppressor through a posttranscriptional ...in tumor tissues by analyzing data from a customized microarray applied to 76 pairs of matched normal and cancer tissue ...transcription ...
14
Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
... of p53 between the senescence and quiescence program in the p53-arrested cells [76, ...the p53-induced quiescence is in fact a result of suppression of senescence by ...of p53 converted ...
10
Tumor Suppressor Gene p53 status in Upper Gastro Intestinal Malignancies
... the p53 protein is kept at low concentration by its relatively short half life of about 20 ...of p53 in the cell and activation of p53 as a transcription factor (11, ...activated p53 ...
77
Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
... of p53 and p73 binding sites within promoter-proximal regions, we have found that approximately 50% of the p53-associated promoters con- tain a p53 consensus site [30], whereas only 20% of the ...
16
An Overview of Stress Response and Hypometabolic Strategies in Caenorhabditis elegans: Conserved and Contrasting Signals with the Mammalian System
... Apoptosis signaling in C. elegans, as in mam- malian systems, can be initiated by the p53 tumor suppressor, CEP-1. CEP-1 transcriptionally up-regulates production of the ‘egg laying abnormal’ (EGL-1) ...
42
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway
... of p53 without shifting the negative feedback loop toward ...of p53 protein levels resulted in efficient viral gene expression during viral replication ...to p53 to suppresses its phos- phorylation ...
9
Therapeutic Potential of Neem Synthesized Silver Nanoparticles on Human Gastric Cancer Cells in Vitro
... that tumor-derived trypsin is involved in the malignant growth of tumor cells, especially stomach cancer cells ...growth factor (EGF) receptor (EGFR) family of tyrosine kinase receptors expressed by ...
21
Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
... important p53-targeting oncomiR to be studied in MM pathogenesis especially drug resist- ance because (a) it has been shown to play an eminent role in normal lymphopoiesis or myelopoiesis and also to func- tion as ...
11
The regulation of cellular metabolism by tumor suppressor p53
... Whereas p53 promotes mitochondrial oxidative phos- phorylation to maintain the homeostasis of cellular en- ergy metabolism, p53 also plays a fundamental role in reducing the intracellular ROS levels mainly ...
10
Tumor Suppressor Gene p53 (mt) Expression in Mancozeb treated Mouse Liver
... The tumor suppressor gene p53 is located, on the short arm of chromosome ...Generally, tumor suppressors are transcription factor that are activated by cellular stress or DNA damage ...
5
Mitochondrial Protein in the Nucleus
... The tumor suppressor p53 is primarily known as a nuclear transcription factor mediating senescence and apoptosis, but it also accumulates in the mitochondrial matrix in response to oxidative ...
7
Smad4: gatekeeper gene in head and neck squamous cell carcinoma
... Key genetic alterations known to exist in HNSCC include a overexpression of the growth factor receptor EGFR; b mutations in the tumor suppressor gene p53; c mutation or overexpression of[r] ...
6
5-Fluorouracil-induced RNA stress engages a TRAIL-DISC- dependent apoptosis axis facilitated by p53
... sensitive tumor cell ...the p53 tumor suppressor plays a central role in DNA damage responses, including DNA repair, the cell cycle regulations and apoptosis, a key focus has been on how these ...
19
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
... the tumor suppressor p53 ( p53 or Trp53 ) ...the p53 pathway and are often associated with the stabilization and accumulation of mutant p53 ...increased p53 expression in ...
11
Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53.
... 5417-5424 0022-538X/91/105417-08$02.00/0 Copyright © 1991, American Society for Microbiology Complex Formation between the Lymphotropic Papovavirus Large Tumor Antigen and the Tumor Supp[r] ...
8
Cell-Specific Modulation of Papovavirus Replication by Tumor Suppressor Protein p53
... that p53 could effi- ciently block the amplificational replication of the papilloma- virus ...of p53 is determined by the RPA binding, proline-rich regulatory, DNA binding, and oligomer- ization domains of ...
10
Materials Discovery by Crystal Growth: Synthesis, Structure Determination, Magnetic, and Optical Properties of Complex Lanthanide Containing Oxides, Oxyhydroxides, and Oxyfluorides
... transcriptionally, a series of experiments were conducted using a TNFa/zVAD-fmk necrotic model system to explore this possibility. In the same manner as the first study, CYLD was shown to be an upregulator of necrotic ...
105
Transcriptome-wide characterization of the endogenous miR- 34A-p53 tumor suppressor network
... to p53, miR-34A may compensate for the effects of mutant p53 in non-transformed ...to tumor development. These studies provide strong insight into the tumor suppressive capacity of miR-34A, ...
12
The Heli-CASE of the Missing WRN Gene
... WRN also co-localizes with p53 which inhibits exonuclease activity and dulls WRN helicase ability to unwind inappropriate DNA structures. The symptoms of aging and genomic instability that Werner Syndrome patients ...
7