PA, phosphatidic acid
A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis
... mitogen phosphatidic acid (PA) must be maintained at low levels until the need arises for cell ...of PA affects its target proteins in the different cellular compartments is not fully ...
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Phorbol myristate acetate, dioctanoylglycerol, and phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule
... control. Phosphatidic acid (PA), which is thought to stimulate phosphatidylinositol (PI) turnover, produced similar inhibitory effects on AVP as well as CcAMP-stimulated Lp: PA suppressed ...
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Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
... Thirty-four males were recruited from the University of Tampa to participate in this study. Twenty eight males (21 ± 3 years, 77 ± 7 kg, 176 ± 9 cm) were used for data analysis. Three subjects elected to discontinue ...
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Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes Effects on activation of NADPH oxidase
... of PA (mass and radiolabel) in a manner that correlated with enhancement or inhibition of O2 consumption in PMN stimulated with 1 microM FMLP in the absence of cytochalasin ...In PA extracted from cells ...
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Different species of phosphatidic acid are produced during neuronal growth and neurosecretion
... PLD1-generated PA in the late steps of exocytosis, such as membrane fusion and/or pore expansion (Vitale et ...PLD1-generated PA was also reported to contribute actively to the regulated secretion of ...
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A Dual Role for Diacylglycerol Kinase Generated Phosphatidic Acid in Autoantibody-Induced Neutrophil Exocytosis
... of PA as a downstream secondary messenger of the activation of DGK in ANCA IgG- stimulated neutrophils through the addi- tion of a short-chain lipid analog of ...
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Phospholipid Metabolism in Stimulated Human Platelets: CHANGES IN PHOSPHATIDYLINOSITOL, PHOSPHATIDIC ACID, AND LYSOPHOSPHOLIPIDS
... and phosphatidic acid (PA) as a consequence of thrombin or collagen ...in PA when thrombin was the ...for PA formation by diglyceride kinase, if hydrolyzed by diglyceride lipase (Bell, ...
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New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass
... of PA by PLD ...in PA requires PLD by using a small-molecule inhibitor of PLD called 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) ...in PA or mTORC1 signaling, suggesting that changes in PLD ...
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The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis
... During the last few years, our laboratory has been involved in delineating the role that a family of enzymes of the de novo lipid biosynthesis pathway, the lipins, has in proinflammatory responses (14–17). Lipins possess ...
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Putting the pH into phosphatidic acid signaling
... 1. Phosphatidic acid is a key precursor in lipid ...from phosphatidic acid (PA) is ...(TAG). PA is drawn in its deprotonated form carrying a charge of ...regulating PA ...
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An efficient modified method for plant leaf lipid extraction results in improved recovery of phosphatidic acid
... An approach, involving the inactivation of lipases with isopropanol and the use of a polar mixture of chloro- form, isopropanol, methanol, and ammonium acetate in water for a long (24 h) extraction, was developed in our ...
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Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy
... lysophospholipids phosphatidic acid (PA), lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) have been implicated in mediating cell migration, proliferation and apoptosis, ...
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Identification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolor
... lysophosphatidic acid (LPA) acyltransferase, generating phosphatidic acid ...(PA). PA can be dephosphorylated by the enzyme phosphatidic acid phosphatase (PAP) yielding ...
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Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis
... We next asked whether the increased CCTα activity and the resultant PC overproduction contribute to dysregulated chylomi- cron production in lipin 2/3–deficient enterocytes. If so, inhibi- tion of CCTα activity should ...
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Saturated phosphatidic acids mediate saturated fatty acid–induced vascular calcification and lipotoxicity
... whether PA or its downstream metabolite is responsible for SFA-induced lipo- toxicity in ...a PA phosphatase, catalyzes the third step of de novo glycerolipid synthesis by converting PA to ...that ...
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Notch1 Augments Intracellular Trafficking of Adeno-Associated Virus Type 2
... Gene expression profile correlating with rAAV2 transduc- tion. In our studies on AAV2 transduction to human epithelial prostate cancer cells, we observed a wide variation in trans- duction efficiency. Whereas PCa2b cells ...
5
Biosynthesis of cytidine diphosphate diglyceride by human platelets
... Homogenates of human platelets contain an enzyme which catalyzes the formation of cytidine diphosphate diglyceride from cytidine triphosphate and phosphatidic acid. The enzymatic activity could not be ...
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Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease
... In summary, we found that the administration of 2ccPA reduced cuprizone- induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction, and promoted remyelinati[r] ...
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Identification of a soluble phosphatidate phosphohydrolase in the developing cotyledons of Momordica charantia
... reaction catalyzed by PAP. In the cytoplasmic mem- branes of plant seed tissue that accumulate storage trigly- cerides (oil), fatty acyl groups are added sequentially by specific acyltransferase enzymes to the sn-1, ...
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Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria
... purple acid phos- phatase (EC ...both phosphatidic acid phosphohydrolase and purple acid phosphatase hydrolyze phosphomonoester bonds and it is possible that their catalytic sites may be ...
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