Paclitaxel-resistance
Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
... µM paclitaxel during 24 ...with paclitaxel (Figure 4A and Supplementary Figure ...After paclitaxel treatment, the changes were most remarkable in PLK1, which accumulated in mock-transfected cells and ...
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The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study
... of paclitaxel to its cellular target [7, 8] and genetic polymorphisms ...of resistance typically produce chemotherapeutic ...that paclitaxel resistance occurs via its active efflux from cancer ...
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Original Article RSK4 activation confers paclitaxel resistance in gastric cancer
... Abstract: Paclitaxel (PTX) has shown encouraging activity in the treatment of advanced gastric ...drug resistance in GC ...to Paclitaxel and discovered a difference in ...mechanism, ...
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Induction of Paclitaxel Resistance by the Kaposi's Sarcoma-Associated Herpesvirus Latent Protein LANA2
... lymphomas. Paclitaxel binds in vitro to the microtubule polymer, enhancing the polymeriza- tion of tubulin (26, 31) and artificially stabilizing microtubules (36, ...to paclitaxel treatment ...the ...
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BRCA1 IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
... BRCA1-IRIS-dependent paclitaxel resistance could be mediated by pro-survival autocrine signaling loops, such as those shown here, namely EGF/EGFR-ErbB2 and ...Although paclitaxel-mediated increases ...
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Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer
... in paclitaxel resistant ovar- ian cancer cell ...of paclitaxel resistance across ovarian ...as paclitaxel, target the spindle assembly checkpoint which affects mitotic progression and arrest, ...
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Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy
... The Hippo signaling pathway, which regulates cell pro- liferation and apoptosis, is a highly conserved signaling pathway first discovered in Drosophila cells. It also exists in mammals and controls organ size, cell ...
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<p>Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells</p>
... used paclitaxel-resistant cell line A2780T and its parental line A2780, along with ovarian cancer biopsies to conduct our ...a paclitaxel-resistant cell line which was derived from A2780 ...of ...
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CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50
... therapeutic resistance. In this study, we show that CapG promotes resistance to chemotherapy, especially paclitaxel resistance, in breast cancer by activating PI3K ...to paclitaxel ...
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Synthetic paclitaxel-octreotide conjugate reversing the resistance of A2780/Taxol to paclitaxel in xenografted tumor in nude mice
... Multidrug resistance gene 1 (MDR1) is known as one of the important mechanisms causing paclitaxel ...intracellular paclitaxel concentration, and results in the reduced inhibitory effect on tumor ...
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Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms
... drug resistance to paclitaxel, the smad3 siRNA was synthesized, then transfected into A549/TAX ...the paclitaxel sensitivity in A549/TAX ...drug resistance to paclitaxel through binding ...
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HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
... and paclitaxel resistance in gastric cancer [23], downregulation of MAPT was also shown to improve taxane response in breast cancer cell lines [24] and in ovarian cancer three-dimensional collagen I matrix ...
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Blockade of VEGFR 1 and VEGFR 2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
... fers resistance to ...overcome paclitaxel resistance in ...and paclitaxel resistance was assessed with small interfering TUBB3 ...and paclitaxel. Results: Hypoxia induced ...
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Non-Coding RNAs Mediate Chemotherapy Resistance in Ovarian Cancer
... chemotherapy resistance in ovarian ...with paclitaxel resistance in ovarian cancer cells and human tumour ...resensitize paclitaxel-resistant cells to paclitaxel by enhancing apoptosis, ...
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Resistance to paclitaxel in a cisplatin resistant ovarian cancer cell line is mediated by P glycoprotein
... to paclitaxel and models the resistance phenotype of relapsed ovarian cancer patients after first-line platinum/taxane ...chemotherapy resistance in IGROVCDDP cells. Paclitaxel ...
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Epstein-Barr Virus (EBV) Genome and Expression in Breast Cancer Tissue: Effect of EBV Infection of Breast Cancer Cells on Resistance to Paclitaxel (Taxol)
... confers paclitaxel resistance to breast carcinoma cell ...This resistance might be a consequence of the higher MDR1 expression that is observed in paclitaxel-resistant EBV- infected cells ...
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Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin
... of resistance to these drugs, we performed pathway analysis using the genes that were found significantly differentially expressed in each resistance ...each resistance phenotypes, some pathways ...
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A systematic review of platinum and taxane resitance from bench to clinic: An inverse relationship
... acquired resistance which report cross resistance data for both cisplatin and paclitaxel identified 137 cell lines 9,11,13-16,19-83 ...fold paclitaxel resistance was plotted against the ...
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PubMedCentral-PMC5065725.pdf
... Brown et al. compared BEP to taxane-based therapy. In this retrospective study the authors found that while patients treated with BEP had a higher response rate than those treated with taxanes, the difference was not ...
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Original Article AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel
... numerous types of human cancer. HER2 overexpression and/or amplification have been detected in various cancers, including gastric cancer. HER2 overexpression/amplification is observed in 5-25% of GC cases [27] and ...
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