Pain Behaviour
Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis
... migratory behaviour similar to chondrocytes, whilst at low passage (p < 4), a reduced ability to undergo chondrogenesis was observed ...established pain behaviour (weight-bearing asymmetry) in MNX ...
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The anti NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain
... receptors, inhibits TrkA auto-phosphorylation 16 , has a plasma half- life of 5 e 6 days in the rodent and low blood brain barrier perme- ability 17 . The preventative study used weekly dosing of muMab 911 (s.c. 10 ...
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Temporal mismatch between pain behaviour, skin Nerve Growth Factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain
... inflammatory pain, NGF has also been proposed to be important in neuropathic pain ...pathic pain [24-26], although whether the effects of NGF neutralization occur centrally or peripherally is not ...
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The Effect of Palmitoylethanolamide Analogue, N-(2-Morpholinoethyl) Palmitoylamide on Pain Behaviour in Mice
... Considerable evidence demonstrating that ∆ 9 -tetrahydrocannabinol (THC), the psychoactive ingredient of Cannabis sativa, and a number of synthetic cannabinoid (CB) receptor agonists have analgesic activity in rodent ...
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Pain-related avoidance and endurance behaviour in migraine: an observational study
... by pain-free ...of pain, behaviour between the attacks ...endurance behaviour “I lost time because of my migraine yesterday, I have to make up for that today”) may be also important in ...
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Behavioural evaluation in patients affected by chronic pain: a preliminary study
... patient pain behaviour during hospitalisation were collected at three different moments of the day by different nursing staff both during the day and during the five days of the ...
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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
... Nav1.7 is expressed in sympathetic as well as sensory neurons 2,17 . By using the Wnt1 promoter to drive Cre expression it is possible to delete genes in neural crest derivatives including autonomic and sensory neurons. ...
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Enhanced implementation of low back pain guidelines in general practice: study protocol of a cluster randomised controlled trial
... b. The SOS questions (Additional file 1) inquires whether the LBP raises concern about work ability, whether the patient plans to have, or already has, compensation claims or seeks pension, or whether there are any other ...
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How incremental video training did not guarantee implementation due to fluctuating population prevalence
... a pain behaviour observation ...required pain behaviour observation with the REPOS, the actual use, which is equivalent to behaviour in our view, decreased during the study ...
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Selective inhibition of tropomyosin receptor kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis
... Pain behaviour was assessed before oral dosing as weight- bearing asymmetry and as punctate allodynia in the hind paw distal to the injected knee, or by paw withdrawal to ankle joint ...
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Managing the symptoms of neuropathic pain: An exploration of patients' experiences
... the pain; hoping that a different intervention might help them; or they may have been driven by ...their pain, through both conventional and alternative ...with pain (eg Calnan et al 17 ...
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A Study of Patient Clinician Interaction and Abnormal Illness Behaviours among Subjects with Chronic Non Organic Pain
... persistent pain (pain should have been present at least daily or on alternate days) for greater than 6 months for which no organic basis was found were ...
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Physical activity patterns among children and adolescents with mild-to-moderate chronic fatigue syndrome/myalgic encephalomyelitis
... Online supplementary tables S2-S5 show the associ- ations between the physical activity latent classes and young people’s self-reported pain, fatigue, anxiety and depression, respectively. Compared with being ...
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Vascular endothelial growth factor A165b prevents diabetic neuropathic pain and sensory neuronal degeneration
... Thirty-seven female Sprague Dawley rats (~250g) were used in this study in accordance with the UK Home Office Animals (Scientific Procedures) Act 1986 and amendments (2012). Experiments were performed in laboratories at ...
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What influences patients with osteoarthritis to consult their GP about their symptoms? A narrative review
... An alternative theoretical lens through which to con- sider access to healthcare is the notion of ‘candidacy’ [29], although this was not described in any of the papers in this review. A ‘candidacy’ perspective suggests ...
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Improving physical activity, pain and function in patients waiting for hip and knee arthroplasty by combining targeted exercise training with behaviour change counselling: study protocol for a randomised controlled trial
... and behaviour change counselling (ENHANCE) trial is a two-arm assessor-blind randomised controlled trial to assess the effectiveness of a 12-week exercise intervention designed to improve long- term physical ...
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Comparative efficacy of three active treatment modules on psychosocial variables in patients with long-term mechanical low-back pain: a randomized-controlled trial
... long-term pain and disability have been implemented in some studies with varied outcomes ranging from no significant to moder- ate effect ...as pain catastrophizing that it did not deliberately ...
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Clinical and cost effectiveness of adapted cognitive behaviour therapy for non cardiac chest pain: a multicentre, randomised controlled trial
... chest pain is a very unsatisfactory one as it is so heterogeneous, and this heterogeneity was emphasised by recruitment from both accident and emergency clinics and cardiology ...
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Multisite peripheral joint pain: a cross sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour
... joint pain (including no pain sites as a reference group), before aggregating these into 5 groups (pain in no sites, pain in any one site, any two sites, any three sites and pain in all ...
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The Fear Reduction Exercised Early (FREE) approach to low back pain: study protocol for a randomised controlled trial
... In a previous study in which Dutch GPs were trained to explore and address psychosocial factors in patients who had subacute LBP, researchers did not find any clin- ically relevant benefits [71]. Jellema et al. [72] ...
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