PAMAM dendrimers
Shape-persistent and adaptive multivalency : Rigid transgeden (TGD) and flexible PAMAM dendrimers for heparin binding
... TGD dendrimers appear, in general, to be less effective heparin binders than their PAMAM ...the PAMAM systems are ...TGD dendrimers to display shape-persistent multivalency, in which the ...
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Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death
... that PAMAM dendrimers could in- duce autophagy in human glioma cells[24], but the underlying relationship and mechanism between ROS and autophagy in PAMAM dendrimers-induced neuronal cell ...
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PAMAM DENDRIMERS AS DRUG DELIVERY CARRIERS, BENEFITS AGAINST RISKSEbtsam M. AbdouDOWNLOAD/VIEW
... cationic dendrimers is controlled by the number of terminal amine function groups on the surface, which increases with increase in dendrimer generation and the dendrimer concentration ...of PAMAM ...
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A novel approach to label bone marrow-derived mesenchymal stem cells with mixed-surface PAMAM dendrimers
... Given the importance of MSCs in various neurological disorders and their therapeutic values of their differenti- ated forms, it is important to be able to track these cells following transplantations into the brain and ...
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A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA, and activated PAMAM dendrimers
... (PAMAM) dendrimers, are potential nonviral gene carriers in this therapy because of their biocompatibility and modifiable ...activated PAMAM dendrimers exhibit higher transfection efficiency, ...
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PAMAM Dendrimers mediated solubility enhancement of poorly soluble drugs: a concise review
... in dendrimers and their corresponding solubilizing .... Dendrimers specifically bespoke to bind hydrophobic guests to the core have been created by the Diederich group under the name ‘dendrophanes 24 ...G ...
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<p>Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation, differentiation, and pro-inflammatory cytokines in human keratinocytes and fibroblasts</p>
... Poly(amidoamine) (PAMAM) dendrimers with ethylene- diamine core (2nd and 3rd generation) were purchased from Sigma Chemical Co. (St. Louis, MO, USA). Human cell lines: keratinocytes and fi broblasts, were ...
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Mutagenicity Survey and Antibacterial Activity of Various Generations of Poly (Amid Amine) (PAMAM) Dendrimers and Algonac Acid Poly (Amid Amine) (PAMAM) Dendrimer Nano Composite G2 on Some Enteric Pathogenic Bacteria
... Algonac acid or alginate is an anionic polysaccharide found in the cell walls of brown algae. When mixing algi- nate with water, a viscous gum is formed. This substance absorbs water quite rapidly in extracted forms. It ...
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Bioconjugates of PAMAM dendrimers with <em>trans</em>-retinal, pyridoxal, and pyridoxal phosphate
... third-generation PAMAM dendrimers, retinal ([Ret] vitamin A), pyridoxal ([Pyr] vitamin B 6 ), or pyridoxal phosphate ([PLP] metabolically active coenzyme of vitamin B 6 ...
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General Fifth M-Zagreb Indices and Fifth M-Zagreb Polynomials of PAMAM Dendrimers
... In this paper, we introduce the general fifth M-Zagreb indices and fifth M 3 -Zagreb index and their polynomials of a molecular graph.. Also we compute.[r] ...
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DENDRIMERS – A NEW CLASS OF POLYMERS
... of PAMAM dendrimers distinctly reduces the cytotoxicity towards Caco-2 ...of dendrimers, creating a highly hydrated dendrimer surface with a low disturbing effect on the physiological ...modified ...
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The breakdown of bilayer lipid membranes by dendrimers
... (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM ...
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Selective aggregation of PAMAM dendrimer nanocarriers and PAMAM/ZnPc nanodrugs on human atheromatous carotid tissues: a photodynamic therapy for atherosclerosis
... of PAMAM dendrimers [76], it was noted that the drying procedure could induce the for- mation of aggregates by capillary forces and, therefore, in- fluence the relative positions of the deposited ...
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DENDRIMERS AND ITS APPLICATION
... 6 PAMAM dendrimers with 12 and 192 terminal surface amines conjugated to the chelating ligand 2-(4- isothiocyanatobenzyl)-6- ethyldiethylenetriamine- pent acetic acid through a thio urea linkage were ...
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DENDRIMERS: NOVEL DRUG NANOCARRIERS
... fluorescein-modified PAMAM not containing folic ...paclitaxel-conjugated dendrimers to KB cells. Internalization was not detected when dendrimers were exposed to down-regulated KB cells 26, 59, 60 ...
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Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro
... Red™-X-labeled PAMAM G3 (RR-PAMAM) and FITC-labeled BC-PAMAM G3 (FITC-BC-PAMAM) dendrimers at concentrations rang- ing from 1 µ M to 50 µ M, extensively washed with PBS, and fixed with ...
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<p>Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vivo Administration of G6 PAMAM Nanoparticles Impairs Recovery of Cardiac Function Following Ischemia-Reperfusion Injury</p>
... 5,6 PAMAM dendrimers have been examined for their use as delivery vehicles for genes to target host cells for the treatment of a variety of ...of PAMAM dendrimers in research and drug ...
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Dendrimers and their Applications
... the dendrimers and guest molecules such as drugs with coulomb attractions causes the guest molecules to pull inside dendrimer structure, and keeps them together by hydrogen ...to dendrimers, encapsulation ...
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Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells
... branched PAMAM dendrimers with nearly spherical shapes display more compact structures and migrate faster than globular protein standards with the same molecular ...of dendrimers was ...
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Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish
... Abstract: Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted ...(size) dendrimers were ...
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