PANC-1
The Effect of Wild Type P53 Gene Transfer on Growth Properties and Tumorigenicity of PANC-1 Tumor Cell Line
... cells, PANC-1, with high amount of mutant p53 and HTB80 with very low amount of wt p53 ...of PANC- 1 cells, which express high amount of mutant p53 (codon 273) protein, exhibited a reduced ...
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RETRACTED ARTICLE: Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways
... According to the previous findings, mitochondrial fission has been acknowledged as a potential target to reduce the proliferation, migration and survival of PANC-1 pancreatic cancer cells [10]. Excessive ...
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Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells
... Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, an- tihelminthic and antiproliferative activities. In the present study, we found that isoalantolac- tone inhibits growth and induces ...
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Gemcitabine loaded albumin nanospheres (GEM ANPs) inhibit PANC 1 cells in vitro and in vivo
... revealed that no significant difference between the ANP treatment group and control group was observed in WBC, RBC, and other parameters of hepatonephric functions, suggesting a satisfactory biocompatibility (Table ...
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<p>Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling</p>
... JNK is a stress-activated protein kinase, which is one of the major members of the mitogen-activated protein kinase (MAPK) family. It is involved in cellular physiol- ogy and pathological processes. The unbalanced ...
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Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells
... of PANC-1 cells in a field strength- and dose-dependent manner and caused apoptotic death of PANC-1 ...on PANC-1 cells through triggering both extrinsic and intrinsic ...
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Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway
... Apoptosis assays by annexin V staining were conducted according to the manufacturer’s instructions (BD Pharming). In brief, PaTu 8988t, Panc-1, and SW 480 cells were incubated with 1 µM of ...
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(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death
... To investigate whether GF-induced cell death in nutrient- deprived medium involves apoptosis, the cell morphology was examined. As shown in Figure 5, at 25 µ M, GF induced a marked change in PANC-1 cell ...
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Selection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage Display and Its Effects on Pancreatic Cancer Cell lines PANC-1 and CFPAC-1
... Despite tremendous advances in cancer treatment and survival rates, pancreatic cancer re- mains one of the most deadly afflictions and the fourth leading cause of cancer deaths in the world. Matrix Metalloproteinases ...
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Original Article Effects of calcitriol on the growth of PANC-1 cell line with vitamin D receptor (VDR) gene silencing
... VDR expression is under a close relationship with the signaling system of cell cycle-regulat- ing agents, such as p21 and p27 proteins. In our study, the percentage of G0/G1 phase cells in siRNA groups was significantly ...
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DEPTOR has growth suppression activity against pancreatic cancer cells
... Given the observation that DEPTOR expression was lost in PDAC tissues, we next determined whether ectopic DEPTOR expression would affect the growth of pancreatic cancer cells. We transfected FLAG-tagged DEPTOR cDNA, ...
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Generation and testing of clinical-grade exosomes for pancreatic cancer
... ma-Lyte). Although modifications of the siRNA may be tested in the future to further improve the stability of the siRNA itself, both sources of siRNA employed in our studies to generate iExosomes showed robust antitumor ...
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A Novel Recombinant Vaccinia Virus Expressing the Human Norepinephrine Transporter Retains Oncolytic Potential and Facilitates Deep-Tissue Imaging
... VACV gene transcription occurs in a temporal manner, with early genes tran- scribed within the core of the virus parti- cle soon after infection, whereas interme- diate and late genes transcribe in the cytoplasm of ...
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DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2
... and PANC-1) versus normal HPDE6 cells ...and PANC-1 cells with siRNAs reduced DUXAP8 expression by ...and PANC-1 ...and PANC-1 cells ...
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MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12
... and PANC-1 cells was decreased after miR-137 upregulating,but was increased after miR-137 ...proliferation, PANC-1 and AsPC-1 cell lines were transfected with KLF12 ...
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miR-337 regulates the proliferation and invasion in pancreatic ductal adenocarcinoma by targeting HOXB7
... pancreatic carcinoma of a ductal cell origin, while As-PC-1 cell line was established from the ascites of a patient with adenocarcinoma of the head of the pancreas. Morpho- logically the two pancreatic tumor ...
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GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer
... Purpose: To investigate the expression and significance of GDF11 in pancreatic cancer. Patients and methods: Pancreatic cancer and corresponding paracancerous tissues (n=28) were collected from the Department of ...
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Original Article Expression and functional perspectives of miR-184 in pancreatic ductal adenocarcinoma
... line PANC-1 was transfected with miR-184 ...untreated PANC-1, miR-184 inhibitor transfected PANC-1 and controlled normal pan- creatic ductal epithelial cell line ...of ...
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<p>Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling</p>
... that PANC-1 and CFPAC-1 cell growth was inhibited by the induc- tion of apoptosis (Figure ...both PANC-1 and CFPAC-1 ...both PANC-1 and CFPAC-1 cells, ...
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Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl
... line PANC-1 and in the primary PDA cell line ASANPaCa before and after treatment with quercetin for 12 h and compared to AsPC-1 ...and PANC-1) using ...
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