Pancreatic Stellate Cells
MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor
... Human pancreatic cancer associated fibroblasts (CAFs) were isolated from pancreatic tumor tissue obtained during pancreatic surgery from patients with resectable pancreatic head adenocarcinoma ...
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Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression
... resident pancreatic stellate cells ...to pancreatic cancer progression, the mechanisms underlying their activation have been being intensively ...promoted pancreatic tumor cell growth, ...
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Transcriptome Profiles and Gene Expression of Min6 Cells Are Altered by Pancreatic Stellate Cells
... of pancreatic β -cells, which perform a pivotal role in maintain- ing glucose homeostasis, is influenced by various factors including nutritional [1] [2] [3], metabolic [4] [5] and hormonal factors [6] [7] ...
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Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway
... in pancreatic cancer (PC) that affects the quality of life for PC ...in pancreatic stellate cells (PSCs), which is activated by sHH secreted from PC cells, and then, neurotrophic ...
13
The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration
... Human pancreatic stellate cells (PSCs) were isolated from pancreatic tumor tissue obtained during pancreatic surgery from patients with resectable pancreatic head adenocarci- ...
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<p>A modified method for isolating human quiescent pancreatic stellate cells</p>
... density gradient centrifugation, which solves the problem of cell purification. However, that method requires specific perfusion equipment and is difficult to perform. Moreover, the experimental results obtained using ...
7
Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8
... promoted pancreatic cancer cell invasion into the 3D gel (Figure 2D) through IL-8, we next examined the effect of IL-8 on the softness of cancer cells, which has been associated with a more invasive ...
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Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis
... Thereafter, cells were incubated for 36–48 h and the number of invading PCCs was ...membrane. Cells were allowed to migrate, and were counted 18–24 h after cell seeding into the upper cham- ...5 ...
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Experimental techniques for the isolation of pancreatic stellate cells
... Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of pancreatic cancers. Less common subtypes include mucinous cystic neoplasms, colloid carcinomas, adenosquamous PDAC, and neuroendocrine ...
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Anti fibrotic effects of phenolic compounds on pancreatic stellate cells
... adenocarcinoma cells [27] and breast carcinoma cells ...to pancreatic fibrogenesis, the majority of pro-fibrotic mediators that initiate fibrosis- related signaling cascades converge at the ...
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Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
... immune cells including cyto- toxic T cells; however, there is an overall immunosuppressive ...PDA. Pancreatic stellate cells (PSCs) and myofibroblasts appear to contribute to the ...
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BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo
... human pancreatic ductal adenocarcinoma (PDAC) ...of pancreatic stellate cells (PSCs), which are key regulators of collagen I production and fibrosis in ...attenuate stellate cell ...
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Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance
... immune cells, extracellular matrix (ECM), as well as many soluble factors are known to stimulate the aggressiveness of PDAC [4 – ...[7]. Pancreatic stellate cells (PSCs) are considered a major ...
12
Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification
... Pancreatic stellate cells (PSC), a prominent stromal cell, contribute to the progression of pancreatic ductal adenocarcinoma ...these cells in a dose- and time-dependent ...both ...
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Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis
... Background: Despite tremendous advancement, cancer still remains one of the leading causes of death worldwide. Inefficiency of current drug delivery regimens is one important factor that limits the therapeutic efficacy ...
11
The pancreatic stellate cell: a star on the rise in pancreatic diseases
... Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share ...
11
Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells
... Abstract: Pancreatic stellate cells (PSCs) are a key component of tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and contribute to drug ...PDAC cells and green ...
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Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
... as pancreatic stellate cells ...tumor cells to stimulate oncogenic signaling and malignant progression of ...PDAC cells remains to be ...PanIN cells were treated with ...
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Cell specific expression of transforming growth factor beta in rat liver Evidence for autocrine regulation of hepatocyte proliferation
... endothelial cells, Kupffer cells (liver macrophages), and lipocytes (Ito or stellate cells) from normal and regenerating ...endothelial cells and Kupffer ...
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Hepatic stellate cells in liver development, regeneration, and cancer
... hepatic stellate cells in the Wt1-null fetal livers show decreased expression of retinaldehyde dehydrogenase 2, an enzyme that catalyzes retinoic acid synthesis ...hepatic stellate cells in ...
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