Pancreatic β-cell
MicroRNA 7a regulates pancreatic β cell function
... of β cells to secrete sufficient insulin to meet the increased metabolic demands asso- ciated with peripheral insulin resistance ...in pancreatic β cell differentiation and function ...to ...
15
Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6
... of β‑cells caused by mitochondrial stress plays an important role in impaired insulin ...on pancreatic β‑cells against mitochondrial stress using mouse pancreatic β‑cell line ...
6
Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control
... stem cell biology suggest that a sustainable treatment approach to cure diabetes mellitus (DM) can be achieved in the near ...for β -cell regeneration. These β cell-specific ...
12
Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
... human pancreatic β cell lines (EndoC-βH1 and EndoC-βH2) that were generated in this ...rodent β cell lines, rat INS-1E and RIN-5F cells and mouse MIN6 and βTC3 cells, displayed either ...
6
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice
... in pancreatic β cell ...in β cells, most likely in its apo ...depleting pancreatic PPARβ/δ, ...stimulating β cell survival and insulin release under conditions of ...
14
Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice
... Pancreatic β cell failure is thought to underlie the progression from glucose intolerance to overt diabetes, and ER stress is implicated in such β cell ...protein β (C/EBPβ) ...
13
Regeneration of the pancreatic β cell
... of β cells should become virtually defined at a certain point, and, afterward, glycemia should be controlled only by that defined cellular ...differentiated β cells (defined as postnatal cells transcribing ...
9
Lessons in human biology from a monogenic pancreatic β cell disease
... Deciphering the complexities of human b cell physiology is critical to our understanding of the pathophysiology behind both type 1 and type 2 diabetes. One way to do this is to study individuals with congenital ...
6
Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
... secreting pancreatic juices with digestive enzymes into the small ...levels. Pancreatic islets are vascularized spheroid clusters of endocrine cells scattered throughout the pancreas comprising only about ...
144
Neuronatin regulates pancreatic β cell insulin content and secretion
... INS1E β cells silenced for Nnat by RNAi were radio- labeled as above and treated with digitonin to specifically permea- bilize plasma membranes, leaving internal (ER, secretory granule) membranes ...
14
β1 integrin is a crucial regulator of pancreatic β cell expansion
... 2003), cell differentiation and proliferation (Kaido et ...in pancreatic endocrine cells (Kaido et ...regulate cell attachment to specific ECMs and the migration of undifferentiated pancreatic ...
13
Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... The Wnt genes encode a large family of secreted glycoprotein growth factors (19 in humans) (71). The Wnt genes are highly conserved between verte- brates, sharing overall sequence identity. Once se- creted, Wnt proteins ...
8
Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
... on β cells, including induction of apoptosis (5, 14, 43), amyloidogenesis (14, 15, 44), mitochondrial dysfunction (45), and inhibition of GSIS (46), possibly due to a nonselective toxic effect of hIAPP as an ...
12
Exercise preserves pancreatic β-cell mass and function in obese OLETF rats
... of β-cells and therefore maintained normal islet architecture (Figures ...in β-cell mass was found between LETO exercise and control rats ...islet β-cells and α-cells scattered throughout the ...
8
S6K1 controls pancreatic β cell size independently of intrauterine growth restriction
... of cell nuclei positive for either insulin or glucagon, as previ- ously described ...in pancreatic sections stained for insulin (guinea pig anti-swine insulin, 1:800, Dako) and cleaved caspase-3 (rabbit ...
13
Development of a conditionally immortalized human pancreatic β cell line
... Oligonucleotides-based array (CGH array). CGH array was performed using SurePrint G3 Human CGH Bundle (4x180K) (Agilent Technologies) fol- lowing the manufacturer’s instructions. Briefly, 1 μg of genomic DNA ...
13
Pancreatic β cell identity requires continual repression of non–β cell programs
... all β cells during development; how- ever, it is not known whether ...for β cell function in the ...regulates cell fate decisions in several tissues, including the pancreas, intestine, and CNS ...
17
The supply chain of human pancreatic β cell lines
... proliferating β cell lines escape from aging, or whether they accumulate time-related damage such as genotoxic insults that would contribute to their fate upon SV40LT ...human β cells are so ...
11
Insulin resistance and pancreatic β cell failure
... Mice that lack insulin receptors in adipocytes are lean and are protected against obesity-related glucose intolerance 7, suggesting that insulin signaling in adipocytes per se may not co[r] ...
6
A CCR2+ myeloid cell niche required for pancreatic β cell growth
... sustain cell renewal after tissue damage is critical to the maintenance of organ function throughout ...myeloid cell–driven tissue remodeling and growth factor sig- nals has been implicated in these defects ...
22