Pancreatic β-cell proliferation
Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
... of pancreatic islet transplantation in type 1 ...human β-cells for transplantation in type 1 diabetics, or to increase residual β-cell mass in type 2 diabetics, is to induce human ...
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Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival
... islet β-cells altered ATP-sensitive K + channel activity and insulin secretion [46], and that inhibition of voltage-gated potassium channel signaling up-regulated Smad3 phosphorylation and induction of nuclear ...
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Overexpression of apelin in Wharton’ jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats
... Methods: A type 2 diabetic rat model was given a high-fat diet combined with low-dose streptozotocin (STZ) injection. The human WJ-MSCs were isolated and subsequently transduced with apelin-expressing lentiviral ...
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Original Article Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling
... increase cell proliferation, inhibit cell apoptosis and induce insulin secre- tion by ...encoding β-catenin, a member of Wnt signal- ing, participating in cadherin-mediated intercel- lular ...
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TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
... RNA array analysis revealed that Frizzled 7 (FZD7) was downregulated when TET1 was overexpressed. As a re- ceptor of the Wnt/β-catenin signal, FZD7 has been shown to be highly expressed in a variety of cancers, ...
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FOXO1-regulated lncRNA LINC01197 inhibits pancreatic adenocarcinoma cell proliferation by restraining Wnt/β-catenin signaling
... that β-catenin binds to LINC01197, which was confirmed by RIP assays in both PANC1 and BxPC3 ...cells. β-Catenin plays a pivotal role in the transduction of Wnt signaling, and dysregulation of ...
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A CCR2+ myeloid cell niche required for pancreatic β cell growth
... significant β cell loss, pancreatic cells may reactivate regenerative programs, leading to some recovery of the islet cell mass through prolif- eration of remnant β cells or ...
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The supply chain of human pancreatic β cell lines
... human β cell line. The NAKT-15 cell line was derived by Moloney murine leukemia virus (MoMLV) long terminal repeat–driven expression of SV40LT and hTERT in islet ...human β cells in terms of ...
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Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
... Inducible β cell–specific Ezh2 expression in vivo promotes β cell replica- ...islet β cells decline with advancing age in mice and humans (19, ...constrain β cell ...
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Development of a conditionally immortalized human pancreatic β cell line
... and β cells (23, 24) and primate hepatic progenitor cell lines ...first β cell line developed with this approach rapidly lost insulin expression ...promising β cell–specific ...
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Essential role of Skp2 mediated p27 degradation in growth and adaptive expansion of pancreatic β cells
... functional β cells, due to either β cell loss caused by immune assault or the lack of compensation to overcome insulin ...late β cell mass has important ramifications for fostering ...
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β1 integrin is a crucial regulator of pancreatic β cell expansion
... of cell cycle arrest, such as ERK-dependent tumor suppressors (Dmbt1, Azgp1, Pdcd4), inhibitors of cyclins (Cdkn1a, Cdkn1c), and cyclin dependent kinases (Cdk5rap1), are upregulated in the RIP-Cre/β1KO ...foster ...
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Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... homophilic cell–cell adhesion molecules (CAMs) ...in cell proliferation, such as Cyclin D1 (25). Data from other cell systems and the pancreas demonstrate that cadherins play an impor- ...
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Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress
... of β-cells was also due to decreased ...in pancreatic β cell line ...the cell viability of NIT-1 ...increased β-cell area ob- served in C57 ...
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Pancreatic β- and α-cell adaptation in response to metabolic changes
... rodent-derived cell lines, platforms were used in which ATP-levels were used as a proxy indicator for islet function (12), insulin protein content (6) or insulin gene expression ...a cell line derived from ...
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Pancreatic cancer–associated retinoblastoma 1 dysfunction enables TGF β to promote proliferation
... inhibit cell cycle progression requires its activation through hypoph- osphorylation (22), and TGF-β–mediated growth inhibition of human PCCs depends on maintaining RB in a hypophosphorylated state ...
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Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the β-catenin pathway
... with pancreatic cancer as well as cell lines was detected using immunohistochemistry (IHC), real-time polymerase chain reaction, and western ...blotting. Cell pro- liferation, transwell, and ...
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Regeneration of the pancreatic β cell
... pluripotent cell lines derived from the inner cell mass of blastocyst-stage embryos (41–43, 45), and their differentiation in cul- ture may reproduce characteristics of early embryonic ...endocrine ...
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Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice
... vivo cell proliferation assays 2-week-old mice were intraperitoneally injected with BrdU (50 mg/kg body ...described. Pancreatic sections were immunostained with an anti-BrdU ...counted. β ...
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Biochemical And Functional Studies Of Histone Deacetylase 3 In Metabolic Tissues
... in β-cells of adult mice. An HDAC3 β-cell specific knockout was generated using the MIP-CreERT transgenic mouse model and while HDAC3 β-cell specific deletion did not increase total ...
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