Papain-Like Cysteine Protease
Spatial motif discovery in papain-like cysteine protease family
... PCP-like protease Staphopain complexed with its inhibitor ...thiol protease from Staphylococcus Aureus V-8 with the E-64 inhibitor, which substantially disturbs the conformation in the active region ...
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The Amino-Terminal Region of Hepatitis E Virus ORF1 Containing a Methyltransferase (Met) and a Papain-Like Cysteine Protease (PCP) Domain Counteracts Type I Interferon Response
... MetPCP of HEV ORF1 inhibits STAT1 but not STAT2 phosphorylation after IFN-β treatment. 339[r] ...
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Hypovirus Papain-Like Protease p48 Is Required for Initiation but Not for Maintenance of Virus RNA Propagation in the Chestnut Blight Fungus Cryphonectria parasitica
... a papain-like cysteine protease domain located within the p29 coding ...N-terminal papain-like protease, p48, and conserved poly- merase and helicase domains (modified ...
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Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
... inhibitors prevent the generation of CLIP, a set of 3-kDa peptides that will be replaced by antigenic pep- tides in the binding groove of the MHC complex in a reaction catalyzed by the human leukocyte anti- gen–DM ...
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Characterization of the rubella virus nonstructural protease domain and its cleavage site.
... the papain-like cysteine protease domain and its cleavage site was expressed with a Sindbis virus ...for protease activity, consistent with the active site of the enzyme being composed ...
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Structural and functional characterization of MERS coronavirus papain-like protease
... four cysteine residues co- ordinating to a zinc ion within the fingertips region in the finger domain ...four cysteine resi- dues (Cys190, Cys193, Cys225 and Cys227) on the corre- sponding ...
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Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8
... We have shown that glycosaminoglycans (GAGs), especially heparin-like compounds, can modulate the catalytic activity some papain-like enzymes [38,39]. Heparan sulfate and heparin are able to interact ...
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A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-Like Proteases of Emerging Coronaviruses
... viral protease activities and the efficacy of protease inhibitors is a high ...the papain-like protease (PLpro) of severe acute respiratory syn- drome coronavirus (SARS-CoV), a ...
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New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8
... related cysteine proteases that belong to the papain family; according to the MEROPS database system [1,2] they are classified as clan CA, family C1 proteases and share structural similarity to human ...
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Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis
... coronavirus papain-like protease by mutagenesis of the required catalytic cysteine residue or inhi- bition with a protease inhibitor blocks viral replication (23, 34, 35, ...for ...
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The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme
... viral cysteine proteases to release 16 nsp’s (35, ...chymotrypsin-like cysteine protease (3CLpro, also called main ...a papain-like protease (PLpro), releasing nsp1, nsp2, ...
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Structural and Immunological Characteristics of a 28-Kilodalton Cruzipain-Like Cysteine Protease of Paragonimus westermani Expressed in the Definitive Host Stage
... 28-kDa cysteine protease by unrooted neighbor-joining tree (A) and phylogram ...cruzipain-like cysteine protease (Pw28CCP) (U70537); 2, ...westermani cysteine proteinase ...
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Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus
... catalytic cysteine, we then examined the oxyanion hole at the S= subsites of HCoV-NL63 PLP2 as a possible inhibitor-binding site for the covalent cysteine protease FIG 7 Analysis of MERS-CoV PLpro ...
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The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
... two papain-like protease domains, termed either PLP1 and PLP2, or PL1pro and ...one papain-like protease domain, which we term ...coronavirus papain-like ...
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Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates
... of cysteine proteases, which have narrow substrate specificities and either a chymotrypsin- or papain-like ...The papain-like protease 1 (PL1 pro ) domain is present in ...
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Eimeripain, a cathepsin b-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella
... B-like protease, based on its sequence homology with human cathepsin B, further confirmed its classification as a papain-like protease with similar characteristics to toxopain-1 from ...
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zjv11825.pdf
... viral protease activities and the efficacy of protease inhibitors is a high ...the papain-like protease (PLpro) of severe acute respiratory syn- drome coronavirus (SARS-CoV), a ...
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Isolation of a Papain like Cysteine Proteases (PLCP) Gene Sequence from the Genomic DNA of Local Carica Papaya Plant
... diseases like hemorrhagic ...thrombin like enzymes for isolation, identification, cloning, purification, characterization and overproduction for commercialization in fields like medical sciences, ...
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Hypovirus Papain-Like Protease p29 Suppresses RNA Silencing in the Natural Fungal Host and in a Heterologous Plant System
... exhibit papain-like protease activity and share striking similarities in the sequences surrounding the catalytic cysteine and histidine residues and the spacing of these essential residues ...
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The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity
... PLpro is one of the two virally encoded proteases that are necessary for SARS-CoV to cleave the coronavirus ORF1A polyprotein into separate peptides that function in replication of SARS-CoV genomic RNA [26]. PLpro has ...
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