Paracoccidioides brasiliensis
Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis
... Paracoccidioides brasiliensis, a dimorphic fungus occur- ring in Central and South America, is responsible for paracoccidioidomycosis (PCM), an endemic disease that could affect at least 10 million people ...
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Expression in Bacteria of the Gene Encoding the gp43 Antigen of Paracoccidioides brasiliensis: Immunological Reactivity of the Recombinant Fusion Proteins
... gp43 is the major diagnostic antigen of Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis (PCM) in humans. In the present study, cDNA of the gp43 gene (PbGP43) was obtained by reverse ...
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Electrophoretic Karyotypes and Genome Sizing of the Pathogenic Fungus Paracoccidioides brasiliensis
... Here we present the karyotype analysis and genome sizing of Paracoccidioides brasiliensis, a pathogen refrac- tory to conventional genetic analysis. We have established pulsed-field gel electrophoresis ...
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Detection of Circulating Paracoccidioides brasiliensis Antigen in Urine of Paracoccidioidomycosis Patients before and during Treatment
... Paracoccidioides brasiliensis is the causal agent of paracoc- cidioidomycosis, a systemic disease that presents a marked tendency toward dissemination with involvement of any organ or ...
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Paracoccidioides brasiliensis 87 Kilodalton Antigen, a Heat Shock Protein Useful in Diagnosis: Characterization, Purification, and Detection in Biopsy Material via Immunohistochemistry
... pathogen Paracoccidioides brasiliensis can be detected in the sera of infected patients, and its levels have been shown to correlate well with response to treatment and with clinical ...P. ...
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Prophylactic and Therapeutic Vaccination Using Dendritic Cells Primed with Peptide 10 Derived from the 43-Kilodalton Glycoprotein of Paracoccidioides brasiliensis
... the Paracoccidioides brasiliensis glycoprotein 43 (gp43), induces a Th1 response that protects mice in an intratracheal ...P. brasiliensis infection ...P. brasiliensis model in BALB/c ...P. ...
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Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs
... The fungus Paracoccidioides brasiliensis (Pb) is the mainly etiological agent of Paracoccidioidomycosis (PCM) that is a severe chronic and systemic mycosis. This myco- sis account with cases widely ...
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The Pathogenic Fungus Paracoccidioides brasiliensis Exports Extracellular Vesicles Containing Highly Immunogenic α-Galactosyl Epitopes
... in Paracoccidioides brasiliensis. P. brasiliensis is a dimorphic fungus that causes human paracoccidioidomycosis ...P. brasiliensis antigens were present in preparations from phylogenetically ...
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Detection and Selection of Microsatellites in the Genome of Paracoccidioides brasiliensis as Molecular Markers for Clinical and Epidemiological Studies
... Paracoccidioides brasiliensis, a thermodimorphic fungus, is the causative agent of the prevalent systemic mycosis in Latin America, paracoccidioidomycosis ...P. brasiliensis in Central and South ...
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Microsatellite Analysis of Three Phylogenetic Species of Paracoccidioides brasiliensis
... Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, an important human systemic mycosis in Latin ...P. brasiliensis was ...
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Influence of Different Media, Incubation Times, and Temperatures for Determining the MICs of Seven Antifungal Agents against Paracoccidioides brasiliensis by Microdilution
... with Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, had been conducted with variable protocols, employing both macrodilution and microdilution tests and including ...
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Detection of Antibodies against Paracoccidioides brasiliensis Melanin in In Vitro and In Vivo Studies during Infection
... pathogen Paracoccidioides brasiliensis pro- duces melanin in its conidial and yeast ...P. brasiliensis were injected into BALB/c mice in order to produce monoclonal antibodies ...P. ...
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Expressed Sequence Tag Analysis of the Human Pathogen Paracoccidioides brasiliensis Yeast Phase: Identification of Putative Homologues of Candida albicans Virulence and Pathogenicity Genes
... Paracoccidioides brasiliensis, a thermodimorphic fungus, is the causative agent of the prevalent systemic mycosis in Latin America, ...P. brasiliensis, and provide a broader basis for further ...
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Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms
... In Paracoccidioides brasiliensis, Gal-3 was reported to play an immunomodulatory role in the host response ...P. brasiliensis growth and vesicle ...
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In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals
... of Paracoccidioides brasiliensis (gp43), the causative agent of Paracoccidioidomycosis (PCM), conferred protection against infectious challenge by the fun- ...
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Detection of Paracoccidioides brasiliensis gp70 Circulating Antigen and Follow Up of Patients Undergoing Antimycotic Therapy
... fungus Paracoccidioides brasiliensis and has a high prevalence in ...P. brasiliensis and are recognized by Western blotting by 100 and 96% of PCM patient sera, ...anti-P. brasiliensis antibody ...
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The PbMDJ1 Gene Belongs to a Conserved MDJ1/LON Locus in Thermodimorphic Pathogenic Fungi and Encodes a Heat Shock Protein That Localizes to both the Mitochondria and Cell Wall of Paracoccidioides brasiliensis
... of Paracoccidioides brasiliensis, a thermodimorphic pathogenic ...P. brasiliensis and that their gene organizations are conserved among thermodimorphic fungi and Aspergillus, where the genes are ...
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Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence
... A mong the endemic deep mycoses having impact on public health in Latin America (1), paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Para- coccidioides genus, is a major source of morbidity (2). ...
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Importance of xenarthrans in the eco epidemiology of Paracoccidioides brasiliensis
... Paracoccidioides brasiliensis is an important pathogenic fungus that causes paracoccidioidomycosis (PCM), a sys- temic mycosis with broad distribution in Latin ...P. brasiliensis has remained unde- ...
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Immunohistochemical detection of a novel 22 to 25 kilodalton glycoprotein of Paracoccidioides brasiliensis in biopsy material and partial characterization by using species specific monoclonal antibodies
... Two murine monoclonal antibodies MAbs specific to Paracoccidioides brasiliensis as determined by enzyme-linked immunosorbent assay [ELISA] and Western blot [immunoblot] were produced by [r] ...
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