paracrine/autocrine
Evaluation of the role of paracrine/autocrine IGF-1 system in skeletal muscle adaptation
... The striking loss o f skeletal muscle mass and strength that occurs in very old animals and humans has been attributed to a number of different effects including impaired muscle regeneration, under-nutrition and lack of ...
145
Corticotropin releasing hormone is produced by rat corticotropes and modulates ACTH secretion in a paracrine/autocrine fashion
... Anterior pituitary hormone secretion is mainly regulated by hypothalamic releasing factors, which reach the pituitary via portal vessels. It has been demonstrated recently that these peptides can also be produced by the ...
8
Pheromones Stimulate Mating and Differentiation via Paracrine and Autocrine Signaling in Cryptococcus neoformans
... a paracrine signaling role, activating morphological changes in mating partner cells that promote cell fusion and conjugation, similar to the role of pheromones in ...an autocrine signaling role, ...
12
Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines
... via autocrine signaling, virus reactivation ex- periments were undertaken in TIME-CCR8 i cell lines and “pooled” transformants ...and paracrine signaling inhibition ...
13
Endothelin 1 is an autocrine/paracrine factor in the mechanism of angiotensin II induced hypertrophy in cultured rat cardiomyocytes
... Abstract To elucidate the cellular mechanism by which angiotensin II ANG II induces cardiac hypertrophy, we investigated the possible autocrine/paracrine role of endogenous endothelin-1 [r] ...
7
Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma
... that autocrine expression of hGH or hPRL in HCC cells increased STAT3 activation, oncogenicity and tumor growth while functional antagonism with hGH-G120R significantly reduced these ...as ...
15
Interleukin 6 A potential autocrine/paracrine factor in Paget's disease of bone
... conditioned by these atypical multinucleated cells (MNC) to determine if pagetic osteoclasts produce an autocrine or paracrine factor that enhances osteoclast formation. Conditioned media from long-term ...
8
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
... Interleukin-6 (IL-6) is one of the most important factors for MM cell growth and survival in vivo [4, 5]. There are two different sources of IL-6 in MM that promote tumor development and maintenance in vivo: ...
17
Endothelin 1 is synthesized and inhibits cyclic adenosine monophosphate dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells
... chromatography. The cells also displayed ET receptor mRNAs and high-affinity binding sites for ET-1, mostly of the ETB type. Electrogenic anion secretion across intact gallbladder mucosa was stimulated by forskolin, ...
9
Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells
... by paracrine SDF-1α/CXCR4 signaling-induced activation of the intracellular FAK-AKT and ERK1/2 signaling pathways and a subsequent IL-6 autocrine loop in ...
13
Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth
... expression vector synthesized and secreted high levels of ANP. These cells also showed significantly lower rates of DNA synthesis under basal and fibroblast growth factor (FGF)- stimulated conditions. Addition of ...
7
The Transient Pore Formed by Homologous Terminal Complement Complexes Functions as a Bidirectional Route for the Transport of Autocrine and Paracrine Signals across Human Cell Membranes
... HUVEC exposed to the terminal complement components released bFGF but not LDH, a marker of cell lysis. Ghosts impacted by homologous MAC released bFGF, IL-1, and IFN,[r] ...
11
Endothelin 1 is an autocrine/paracrine growth factor for human cancer cell lines
... These results demonstrate that ET-1 is synthesized by and released from human epithelial carcinoma cell lines, and that exogenous and endogenous ET-1 stimulates proliferation of the cell[r] ...
6
Energy Homeostasis by the Peripheral Serotonergic System
... Pregnancy dramatically changes maternal metabolism. In order to maintain the flow of nutrition to fetus, insulin resistance in the mother increases, resulting in an increasing demand for insulin. In order to compensate ...
18
Gene Expression Profiling in Surrogate Tissues to Identify Biomarkers Following Conazole Exposure
... Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in the cardiovas[r] ...
106
Rotavirus NSP1 Protein Inhibits Interferon-Mediated STAT1 Activation
... V iral infection of host cells activates a potent innate immune response that, unless actively subverted by the invading virus, results in the establishment of an antiviral state capable of restrict- ing viral ...
13
Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, ...
7
Dental pulp stem cells : an attractive alternative for cell therapy in ischemic stroke
... The therapeutic effects of DPSCs in stroke are attributed to 1 paracrine or autocrine production of cytokines and growth factors, 2 neural replacement through differentiation into neuron[r] ...
10
Expression of Interleukins (ILs) mRNA in Otitis Media
... Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action). There are bo[r] ...
8
Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF 1 signaling activation
... Several authors suggested that IGF-1 pathway operates in an autocrine/paracrine mode acting as an intrinsic mediator of skeletal muscle repair and adaptation, increasing the proliferatio[r] ...
12