Paracrine effects
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance
... cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells of the tumor microenvironment resulting in the production of paracrine-acting ...
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Paracrine effects of intraocularly implanted cells on degenerating retinas in mice
... neurotrophic effects to retain recipient functional neurons, or both, is still under ...by paracrine effects because no cell substitution was observed in the grafted eyes [1, 2, 6, ...
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Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage
... marker (E-cadherin) (Additional file 1: Figure S1B, a-h). And then, we established a co-culture system to elucidate whether hAEC-secreting factors could influence CTX- induced apoptosis in hGL cells (Fig. 4a). Results ...
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Paracrine effects of embryo derived FGF4 and BMP4 during pig trophoblast elongation
... Expression of BMP4 identi fi es the ExE developing on top of the egg cylinder in the mouse. The lack of an equivalent anatomical structure in species developing from fl at ED led us to study the source of this growth ...
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Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth
... endothelial cells and vascular smooth muscle cells (VSMC) in culture. However, it is not known if the locally synthesized ANP would act similarly. Because cultured endothelial cells and VSMC have lost the ability to ...
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FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction
... present, paracrine effects have been heavily impli- cated in MSC-based improved cardiac dysfunction after MI ...the paracrine secretion effects of donor BM-MSCs were suppressed by hypoxic ...
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Biology of primate relaxin: A paracrine signal in early pregnancy?
... numerous effects in a variety of tissues across a broad range of ...biological effects and advances in relaxin enabling ...its paracrine effects on pregnancy using genomic and proteomic ...
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Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma
... CD109 knockdown in HUVEC enhanced paracrine effects on hepatoma cells proliferation, migration, and invasion in vitro HCCLM3 and HepG2 cells proliferations were significantly increased w[r] ...
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Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing
... the paracrine effects of MSCs on tissue regen- eration, further investigations of the crosstalk between mitochondria-recipient BMSCs and other cell types ...
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Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts
... their paracrine effects on organ damage repair and microenvironmental and immune regulation [32] and have been shown to promote organ and tissue repair ...protective effects on DCD liver grafts by ...
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A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction
... cells; paracrine effects related to the secretion of various cytokines like vascular endothelial growth factor (VEGF), interleukin (IL)-6, platelet-derived growth factor, fibro- blast growth factor (FGF), ...
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Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells.
... However, the mechanism underlying MSC treatment is still unclear. Some scientists think that the rate of MSC colonization in the liver is low, with very few MSCs transforming into functional cells (Anjos-Afonso et al., ...
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miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts
... cells that were exposed to miRZip-C-SFCM. However, the invasion/migration of MDA-MB-231 cells were significantly reduced upon incubation with SFCM from pre-miR cells as compared to the corresponding control cells (Figure ...
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High Levels Production of Recombinant Human Activin A—Effect upon in Vivo Follicle Stimulation
... by paracrine and autocrine ovarian factors [43] ...featuring paracrine and autocrine regulation of this protein in process of folliculogenesis [40] ...
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Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?
... elevated paracrine Wnt signals in the context of tumori- genesis can exert distinct outcomes on the receiving cells within breast xenograft models and emphasize the challenge of deciphering Wnt interactions in ...
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Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation
... osteogenesis. Paracrine factors secreted by mechanically stimulated osteocytes significantly enhanced MSC migration, proliferation and osteogenesis and furthermore significantly increased osteoblast migration and ...
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Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... Background: Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a ...
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Rotavirus NSP1 Protein Inhibits Interferon-Mediated STAT1 Activation
... In clear contrast to findings early during rotavirus infection, at 16 hpi, we found that RV-infected cells effectively resist exogenous IFN-mediated pY701-STAT1 activation (Fig. 3). In the absence of any exogenous ...
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Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells
... PSCs promoted the chemoresistance of PCCs to GEM, which was at least partially mediated by paracrine SDF- 1α signaling. Our findings suggested that blocking the PSC-PCC interaction by inhibiting the SDF-1α/CXCR4 ...
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Adolescent Varicocele: Who Is at Risk?
... length, and penile circumference that accompanies the exaggerated pubertal development reflects the imbal- ance in action of different endocrine and paracrine growth factors and therefor[r] ...
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