parasite clearance
Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
... transformed parasite measurements, irrespective of the shape of the relationship with time ...the parasite population ...the parasite counts at the initial time period and as a result the slope of ...
13
Prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria
... delayed parasite clearance in vitro and in vivo [44, ...prolonged parasite clearance was found after treatment with artesunate and ...prolonged parasite clearance by ...
6
Study clinical response and parasite clearance response to Artemisinins in severe malaria in children
... In the present study, out of 18 cases, 72.2% (13/18) were successfully discharged. 22.2% (4/18) took Leave Against Medical Advice (LAMA) and 1 (5.6%) was certified dead. All 18 cases had shown parasite ...
7
Assessing parasite clearance during uncomplicated <em>Plasmodium falciparum </em>infection treated with artesunate monotherapy in Suriname
... To monitor emerging artemisinin resistance in Suriname, we conducted a single-arm prospective efficacy trial in patients with uncomplicated P. falciparum infection. In order to avoid confounding by partner drugs, the ...
7
Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children
... Non-artemisinin monotherapy and non-artemisinin combination therapy were associated with significantly increased proportions of children with delay in clear- ance. These findings call for a new strategy to determine the ...
11
A robust design for identification of the Parasite Clearance Estimator
... the parasite clear- ance time, defined as the time from the start of treatment to a parasite count below the microscopy limit of detec- ...individual’s parasite clearance time vary although ...
6
Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate treated individuals with imported severe Plasmodium falciparum malaria
... The parasite clearance times according to mixed ef- fects model are shown in Figure 2 and Table ...to parasite clear- ...treatment-related parasite clearance times (Additional file 1) ...
9
The parasite clearance curve
... in clearance of the circulating para- sitized erythrocytes in the so-called benign malarias, or in the case of falciparum malaria, death of the seques- tered parasites ...blood parasite counts are ...of ...
8
Malaria parasite clearance from patients following artemisinin-based combination therapy in Côte d’Ivoire
... the two ACTs remain efficacious in the treatment of Plasmodium falciparum uncomplicated malaria. Polymerase chain reaction (PCR)-corrected 28-day adequate clinical and parasitological response (ACPR) for each ACT was ...
8
Malaria parasite clearance
... malaria parasite killing and clearance appear to be first order pro- ...Splenic clearance functions increase markedly in acute ...a parasite clearance ...on parasite ...
14
Malaria parasite clearance rate regression: an R software package for a Bayesian hierarchical regression model
... slow parasite clearance can indicate ...slow parasite clearance could also be related to host factors such as decreased immunity, inadequate dosing or poor drug ...to parasite ...
16
Malaria Induces Anemia through CD8+ T Cell Dependent Parasite Clearance and Erythrocyte Removal in the Spleen
... on parasite control and ...of parasite burden and ...relative parasite mass and its change in the spleen and liver, correlated with ...liver parasite loads were established by qPCR from rats ...
13
Early variations in plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin based combinations: implications on delayed parasite clearance
... the clearance of the para- sites from the blood by exposing the parasites to the drug and driving them to the spleen where they are cleared from the blood (Happi and Sowunmi, personal ...
8
How robust are malaria parasite clearance rates as indicators of drug effectiveness and resistance?
... Impact of dosing regimen and increasing parasite cell cycle time on iRBC clearance rates 187.. 188.[r] ...
37
Effect of Artemether Treatment on Plasma Lipid Profile in Malaria
... sustained parasite clearance was obtained [42], the mean serum concentrations of triglycerides and LDL-cho- lesterol were significantly reduced from the baseline pre-treatment values after complete ...
11
Plasmodium falciparum Kelch 13 mutations and treatment response in patients in Hpa Pun District, Northern Kayin State, Myanmar
... This report presents data collected in 2013 from a remote region along the Myanmar–Thai border in Hpa- pun District, Myanmar (Fig. 1). While artemisinin resist- ance was well established by 2010 [4] in the border ...
7
Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti malarial plants?
... best parasite clearance, but for which there is almost no ethnobotanical information in the international literature, so it had a very low ethnobotanical ...
9
Plasmodium falciparum clearance in clinical studies of artesunate amodiaquine and comparator treatments in sub Saharan Africa, 1999–2009
... of parasite clearance was by modified intent-to-treat (ITT), including all participants who were randomized and received the study ...secutive parasite slide results (Day 0, Day 1, Day 2, Day 3, Day ...
11
Plasmodium falciparum clearance with artemisinin based combination therapy (ACT) in patients with glucose 6 phosphate dehydrogenase deficiency in Mali
... Other factors such as the molecular biology methods used to determine G6PD deficiency used in our study may also undermine the role of G6PD deficiency in parasite clearance. Enzyme assay appears to better ...
7
Manual exchange transfusion for severe imported falciparum malaria: a retrospective study
... Patients were divided into the intervention group, which received exchange transfusion, and the control group. This retrospective study was not random. Patients in the intervention group received exchange transfusion ...
5