Parasite Clearance Time
Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children
... the parasite density was calculated as- suming a leukocyte count of 6000/ μ l of blood ...considered parasite negative if no asexual or sexual parasite was detected after examin- ation of 200 ...
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Nji, Akindeh Mbuh (2013): Modeling response and delayance to parasite clearance time to artemisinin combination therapies(ACT). Dissertation, LMU München: Medizinische Fakultät
... malaria parasite may use repetitive, immuno-dominant epitopes as a mechanism to evade the immune response of the human host [72] and many of malaria antigens contain tandem arrays of relatively short ...
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Statin Treatment Modulates Clinical Response to Amodiaquine in Acute Uncomplicated Falciparum Malaria
... the parasite clearance time in respect of the control subjects treated with amodiaquine alone in the present study and that reported in the earlier study both differed significantly ...that ...
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Journal of Applied Pharmaceutical Science
... in parasite clearance time as evidenced by ≥ 10% of cases with parasites detectable on day 3 after treatment with an ACT (WHO, 2013), that AL is known for rapid parasitemia clearance by the ...
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A robust design for identification of the Parasite Clearance Estimator
... the parasite clear- ance time, defined as the time from the start of treatment to a parasite count below the microscopy limit of detec- ...individual’s parasite clearance ...
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High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine pyrimethamine treatment failures in vivo in Gabonese children
... cumulative parasite clearance time distribution for the 29 study subjects was as follows: 17% (5/29), 57% (13/23) and 60% (6/10) cleared parasites by days 1, 2 and 3, ...a parasite ...
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Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children
... sensitive, clearance of parasitaemia without recurrence; RI (mild resistance) = parasitaemia disappears but reap- pears within 7 to 14 days; RII (moderate resistance) = decrease of parasitaemia but no complete ...
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Assessing parasite clearance during uncomplicated <em>Plasmodium falciparum </em>infection treated with artesunate monotherapy in Suriname
... The parasite clearance estimator established by WWARN was used to identify the lag phase, clean the data for outliers, and determine the best model (linear, quadratic, cuboidal) to fit the log-transformed ...
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Study clinical response and parasite clearance response to Artemisinins in severe malaria in children
... Results: The mean age was 8.34±4.35 years. Males and females were equally affected. 61% of severe malaria patients were infected by P. falciparum and remaining were infected by P. vivax. The most common clinical features ...
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Plasmodium falciparum clearance in clinical studies of artesunate amodiaquine and comparator treatments in sub Saharan Africa, 1999–2009
... rapid parasite killing and faster clearance to artemisinin-containing combination therapy ...slower parasite clearance, while ACT remain generally effective both clinically and ...
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Measuring the efficacy of anti malarial drugs in vivo: quantitative PCR measurement of parasite clearance
... Parasite Clearance Time (PCT) is estimated by mea- suring change in peripheral parasitaemia in a sequence of samples taken after treatment, typically for 72 hours, and currently this requires ...
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Comparative Study of Therapeutic Efficacy between Quinine and Artemisinin Combination Therapy in Cases of Malaria at Tertiary Care Hospital
... fever clearance time (FCT) and parasite clearance time (PCT) were not statistically significant in treatment group A(Artemisinin) and group B (Quinine) but the mean duration of hospital ...
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Malaria parasite clearance
... stage parasite clearance fol- lowing treatment with artemisinin derivatives in non- immune patients ...positive parasite-negative red cells (RESA + RBCs) are usually present at low densities before ...
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Plasmodium falciparum clearance with artemisinin based combination therapy (ACT) in patients with glucose 6 phosphate dehydrogenase deficiency in Mali
... parum clearance in malaria patients with haemoglobin E trait compared to patients treated with other anti- malarials ...in parasite susceptibility to chloroquine in Hb AS and Hb AA red blood cells in vitro ...
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Plasmodium falciparum Kelch 13 mutations and treatment response in patients in Hpa Pun District, Northern Kayin State, Myanmar
... This report presents data collected in 2013 from a remote region along the Myanmar–Thai border in Hpa- pun District, Myanmar (Fig. 1). While artemisinin resist- ance was well established by 2010 [4] in the border ...
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Effect of Artemether Treatment on Plasma Lipid Profile in Malaria
... The parasite is critically dependent on macromolecules derived from host plasma and erythrocyte ...that parasite growth was complete using serum-free medium supplemented only with a human high density ...
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Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti malarial plants?
... best parasite clearance, but for which there is almost no ethnobotanical information in the international literature, so it had a very low ethnobotanical ...
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Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate treated individuals with imported severe Plasmodium falciparum malaria
... malaria in industrialized countries is still associated with a case-fatality rate of up to 10% [6]. In an effort to fur- ther reduce the mortality of severe malaria, exchange transfusion (ET) is often used as an adjunct ...
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Malaria parasite clearance from patients following artemisinin-based combination therapy in Côte d’Ivoire
... exact time of parasite count is not recorded. In addition, this time could vary by several hours depending on the timing of the visit to the clinic at inclusion and during the follow-up ...of ...
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Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance
... Patients were enrolled from October 2012 to February 2016 at 3 adjacent district hospital sites at Kudat, Kota Marudu and Pitas in northwest Sabah, Malaysia. Patients weighing more than 10 kg and up to 65 years of age ...
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