PARTIAL-ONSET SEIZURES
Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
... for partial onset seizures in infants and children from one month of ...with partial onset ...with partial onset seizures is encouraging, although more work needs ...
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Retigabine (Ezogabine) for Management of Partial onset Seizures: A Mini Review
... Epilepsy, a neurological disorder is currently the target of many drug research companies who are constantly involved in the development of new therapies with novel mechanism of actions as the current plethora of anti ...
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Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures
... of partial-onset seizures refractory to 1 to 3 AEDs were randomized to levetiracetam XR (n = 79) or placebo (n = ...of partial-onset seizures per week over the 12-week treatment ...
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Profile of perampanel and its potential in the treatment of partial onset seizures
... Abstract: Perampanel (PER) is a novel antiepileptic compound that decreases neuronal excitability by modulating glutamatergic transmission through selective noncompetitive blockade of AMPA receptors. PER has been ...
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Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures
... of AEDs with different mechanisms of action to attain the goal of complete seizure control with fewer side-effects. As a group, the sodium channel blockers are among the most frequently prescribed medications in the ...
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A descriptive analysis of drug treatment patterns and burden of illness for pediatric patients diagnosed with partial-onset seizures in the USA
... Finally, several limitations relating to the use of claims data should be considered when interpreting the results of the present study. Claims data are collected for payment, not for research, and are subject to ...
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Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures
... Ezogabine is an ethyl N-(2-amino-4-[{4-fluorophenyl}methylamino]phenyl carbamate) (Figure 1). Previously known as D-23129, it is also known by the inter- national nonproprietary name of retigabine in Europe and most of ...
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Clinical utility of adjunctive retigabine in partial onset seizures in adults
... generalized seizures both in pediatric or adult populations, especially when used in newly diagnosed ...with partial-onset seizures or Lennox-Gastaut syn- drome have been ...
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Lacosamide for the prevention of partial onset seizures in epileptic adults
... of partial-onset seizures were ...four partial-onset seizures per 28 days, with seizure-free periods no longer than 21 days, during the eight-week period before enrollment as ...
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Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability
... Abstract: Perampanel (PER) is a novel antiepileptic drug recently introduced for the adjunctive treatment in epilepsy patients aged 12 years or older with partial-onset seizures with or without ...
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Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures
... exhibits inhibitory activity on neuronal voltage-gated sodium channels playing a role as a partial antagonist. BRV is currently waiting for approval both in the United States and the European Union as adjunctive ...
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Efficacy and safety of brivaracetam for partial-onset seizures in 3 pooled clinical studies
... The safety population comprised all patients ran- domized to BRV dosages of 50, 100, or 200 mg/d, or placebo, who took # 1 dose of study drug, including those taking con- comitant LEV.. [r] ...
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Clinical efficacy of perampanel for partial-onset and primary generalized tonic-clonic seizures
... treating partial-onset seizures should be any different from the adverse effects when it is used for treating primary generalized ...in partial-onset seizures have been compared ...
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Management of refractory complex partial seizures: current state of the art
... Currently there are five “classical” first-line AEDs and 11 new AEDs available in the US and in many other countries (Table 3). Unfortunately, few direct comparisons provide data with which to determine the relative ...
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Clinical utility of eslicarbazepine: current evidence
... with partial-onset seizures, with or without secondary generaliza- ...focal seizures have been assessed in four randomized clinical trials, and responder rates (percentage of patients with a ...
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Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
... The RNS System is the first device that provides responsive neurostimulation and has shown acute and sustained efficacy, tolerability, and safety in adults with medically intractable partial onset ...
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Brivaracetam: brief clinical profile of a new antiepileptic drug
... for partial-onset seizures with or without secondary generalization (spreading to both sides of the brain after the initial seizure) in patients aged ≥16 years, and is awaiting approval in the USA, ...
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Update on treatment of partial onset epilepsy: role of eslicarbazepine
... for partial-onset seizures in adults with epilepsy, a one-year, open-label treatment extension with ESL in patients who completed a placebo- controlled pivotal study was ...with ...
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Adjunctive pregabalin vs gabapentin for focal seizuresInterpretation of comparative outcomes
... the expected difference between treatments would be 17% in favor of pregabalin. At the time this study was planned (2006–2007), gaba- pentin and pregabalin were part of the armamen- tarium available for the treatment of ...
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New developments in the treatment of partial-onset epilepsy
... with partial-onset seizures will achieve control with antiepileptic medication, a considerable minority will have difficult-to-treat epilepsy that is resistant to existing ...only ...
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