pathological response.
Neoadjuvant trials in early breast cancer : pathological response at surgery and correlation to longer term outcomes – what does it all mean?
... the response of the primary tumour (pCR) and longer-term outcomes would be ...although pathological response is not complete, eradication of micro-metastatic disease is observed at the time of sur- ...
12
Circulating serum microRNA-345 correlates with unfavorable pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer
... radiation response to CRT have been reported in the ...pre-CRT pathological response in LARC, we analyzed global miRNA expression in CRT-sensitive and CRT-resistant groups before ...
11
Assessment of Pathological Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Carcnoma
... Locally advanced breast cancer (LABC) occurs relatively infrequently and poses a significant clinical challenge. Even with combined-modality therapy and the use of novel drugs, long-term disease-free survival is ...
82
Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304
... with pathological response and survival of the patients with ...the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic ...
8
Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy
... the pathological heterogeneity between CLM was not explicitly ...of pathological heterogeneity >50% between CLM was of ...poor response for primary tumours and lymph ...
10
Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer
... Pharmacometabolomics is an innovative “omic” methodology that is able to access patients’ biochemical status and is therefore useful to understand the host’s response to drug treatments. This new approach is based ...
14
<p>Review and perspective on adjuvant and neoadjuvant immunotherapies in NSCLC</p>
... only pathological stage and viable tumor ( ≤ 10%) associated with OS (HR ...major pathological response (MPR), de fi ned as 10% or less residual tumor tissue in resected lung and lymph node tissue, ...
8
ISLET CELL ADENOMA IN CHILDHOOD: REPORT OF A CASE
... The findings of hypoglycemia precipitated by fasting, hypoglycemia regu- lanly induced following oral glucose inges- tion, and the pathological response to intra- venous tolbutamide are [r] ...
11
Phase II Clinical Trial of Concurrent Neoadjuvant Chemotherapy With Radiotherapy in Locally Advanced Breast Cancer
... However, a small subset of women receiving neoadjuvant chemotherapy who achieve a complete pathological response, or pCR, (defined as no residual invasive breast c[r] ...
284
Minimal residual disease in cancer of the oesophagus and gastro oesophageal junction
... CANCER OF THE OESOPHAGUS AND GASTRO- OESOPHAGEAL JUNCTION ISOLATED TUMOUR CELLS IN PATHOLOGICAL NODE NEGATIVE LYMPH NODES COMPLETE PATHOLOGICAL RESPONSE TO NEOADJUVANT CHEMORADIOTHERAPY [r] ...
130
A Feedback-Response Pause Normalises Response Perseveration Deficits in Pathological Gamblers
... to response modulation deficit, namely ‘relieving nonpunishment’, which relates to the rewarding effects of the omission/termination of expected punishment – in gambling, a win is much more than an isolated ...
21
CNS RESPONSE IN A RABID BRAIN: A PATHOLOGICAL VIEW
... an iNOS inhibitor significantly increased the survival time of rabies virus-infected mice. Extension of the survival time as accompanied by delayed viral replication, slow progression to apoptotic death and delayed ...
8
Is Meniere Disease Caused by a Pathological Immune Response?
... Inner ear immune reactions may play a significant role in various types of inner ear disorders, such as progressive bilateral sensorineural hearing loss [10], MD [11] and delayed EH [12]. Derebery et al. (1991) ...
7
Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface
... reverse pathological hypertrophy in the face of sustained mechanical loading suggests that stress-induced damage is ongoing and dynamic, and a potential target for therapeutic ...
17
Infectious disease, the innate immune response, and fibrosis
... fibrotic response in a number of organs (Table 1), Schistosoma mansoni provides a well studied example of a multicellular para- site that induces prominent fibrotic responses in the alimentary system during the ...
10
Exercise for the heart: signaling pathways
... Although evidence of the protective effects of physical exercise against cardiac injury is strong, certain caveats need to be noted. First, the optimal level of exercise for preventing CVD is unclear. In some studies, ...
12
A TEST OF CONNECTIVE TISSUE STATE AND REACTIVITY IN COLLAGEN DISEASES
... The time-response curve in the patient with three characteristics of these pathological con- systemic lupus erythematosus receiving prednisone ditions may be distinguished: 1 the initial[r] ...
10
Pathological complete response by advanced hepatocellular carcinoma with massive macrovascular invasion to hepatic arterial infusion chemotherapy: a case report
... HAIC uses high concentrations of anticancer agents administered directly into the hepatic artery via an injec- tion port. It can enhance efficacy of drugs by localizing their application and minimizing systemic adverse ...
6
Fibrosis: ultimate and proximate causes
... counter-regulatory response involving NFE2-related factor 2 (NRF2) in aged animals; this NOX4/NRF2 imbalance leads to persistent fibrosis associated with the acquisition of a senescent and apoptosis-resistant myo- ...
6
Bigger is not better: cortisol induced cardiac growth and dysfunction in salmonids
... Stress- and cortisol-induced cardiac hypertrophy may not be limited to mammals. Cardiac remodelling and deformities are commonly reported in farmed fish (Poppe et al., 2007), but a link between stress and development of ...
9