patient-derived brain cells
Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma
... surrounding brain parenchyma, with an emphasis on the crosstalk between tumour and endothelial ...to-mouse patient-derived glioblastoma xenografts, which similar to our previously described rat ...
17
Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs
... midbrain neurons, which was previously reported to be involved in disease-specific phenotypes in an A53T model of PD [53] and is a hallmark of PD pathology [67]. PGC1α is a master regulator of mitochondrial func- tion ...
18
3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
... smaller brain, particularly affecting cerebral cortex size [41, ...reduced brain size as was observed in human patients [43, ...iPSCs derived from a microcephalic patient with a heterozygous ...
12
Patient-derived glioblastoma stem cells respond differentially to targeted therapies
... among brain cancers ...stem cells (GSCs) [5–8]. GSCs are tumor cells with a neural stem cell-like phenotype that perhaps sustain tumor growth through asymmetric division and increase the tumor ...
14
Isolation of Borna Disease Virus from Human Brain Tissue
... OL cells with brain homogenates from ...tured cells can be facilitated by the use of passages in labora- tory ...P2 brain tissue harbored BDV RNA in their brains and spinal ...gerbil ...
11
In silico modeling predicts drug sensitivity of patient derived cancer cells
... particularly brain cancers ...in brain cancers [8]. More recently, brain tumor models have been used to determine the effects of conventional therapies in- cluding chemotherapy and radiation ...[5]. ...
13
An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
... primary brain pericytes and neural progenitor-derived astrocytes and neurons, approaching in vivo TEER meas- urements ...using patient derived iPSC ...cell-derived brain pericyte ...
12
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
... the brain blood vessels are known to be an important barrier for delivery of many molecular drugs that would otherwise pass through the endothelial cells, and the tumor model was found to have a non-leaky ...
10
Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments
... the brain tumor field has made meaningful progress in animal testing platforms using patient-derived tumorspheres [10, 22–24] and enzymatically dissociated cells ...tumor cells, the ...
6
A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors
... malignant brain tumors is not practical by virtue of their anatomical loca- tion and the relationship of this diffuse disease relative to eloquent functional ...nant brain tumors, however, combined surgical ...
11
Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells
... cancer cells, few have studied their effects on glioma ...on cells from tumors that have recurred following standard ...of cells from primary gliomas, cells from recurrent gliomas from the ...
9
STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation
... utilized patient-derived stem cell lines from lung-to-brain metastases to examine the regulatory role of STAT3 in brain metastasis initiating cells ...
17
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
... MS patient-derived PBMC from with different types of MS were used ...NK cells subpopulation proportion, and, we found they were comparable between samples (Supplemental ...that brain ...
14
Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes
... Since ADSCs are promising material for cell therapy and tissue engineering, their secretome has been ana- lyzed in many studies using various qualitative and quantitative approaches (for details see [8, 23] and ref- ...
12
Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke
... Our recent study showed that allogenic ADMSC/ ADMSC-derived exosome therapy significantly protected kidney architecture, glomerular ultrastructure and renal function from acute kidney ischemia-reperfusion injury ...
20
Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells
... MSC-NTF cells after intrastriatal transplantation in ...pre-labeled cells migrated and ...the cells were attracted Table 6 Histopathological findings in male and female C57BL/6 J mice following ...
11
Pharmacogenomic analysis of patient derived tumor cells in gynecologic cancers
... therapy. The tumor suppressor protein p53 provides an es- sential role in governing cell cycle arrest or apoptosis upon DNA damage [53]. However, the underlying molecular cas- cades that determine p53 protein stability ...
13
15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases
... ing signaling taking place during adhesion process as well as downregulating endothelial CAMs expression, thereby giving a significant additive effect on inhibition on adhe- sion of monocytes. To further understand the ...
10
Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
... cell type, dhBMECs were either derived from GFP- expressing BC1 iPSCs or stained for Glut-1, and dhPCs were stained for calponin. Irrespective of the seeding order, dhPCs were predominantly localized between the ...
16
PSA NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival
... 4°C. Cells were then fixed with 4% PAF and incubated with the secondary antibody linked to ...Ninety cells at each time point in three different experiments were randomly ...of cells falling in each ...
10