PDGF-A
Sequence and translation initiation properties of the xenopus TGFbeta5, PDGF A, and PDGF alpha receptor 5' untranslated regions
... human PDGF-A 5’UTR ...Xenopus PDGF-A 5’UTR is identical to human 18S rRNA interacting with the picornavirus and PDGF2/c-sis ...Xenopus PDGF-A 5’UTR could contain an IRES. However, neither the ...
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PDGF-Rα gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts
... whether PDGF-A can directly stim- ulate αSMA expression in mouse lung ...with PDGF-AA and observed that PDGF-AA suppressed αSMA mRNA expression only in sub-confluent, but had no effect in confluent ...
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Upregulation of platelet derived growth factor A and B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis
... both PDGF-A and -B, but PDGF-B mRNA is 10-fold more ...both PDGF-A and -B mRNA levels were markedly increased, with persistence of the 10-fold dominance of PDGF-B ...
6
Reicherzer, Tobias (2020): Mesenchymale Stromazellen aus der Lunge extrem unreifer Frühgeborener und ihre Wechselwirkung mit der pulmonalen Entzündungsreaktion. Dissertation, LMU München: Medizinische Fakultät
... the PDGF signaling pathway — previously associated only with myofibroblast migration and secondary septation of air sacs—is capable to produce both the alve- olar structural and microvascular pathology of nCLD is ...
62
Platelet derived growth factor activity and mRNA expression in healing vascular grafts in baboons Association in vivo of platelet derived growth factor mRNA and protein with cellular proliferation
... of PDGF-A chain mRNA in the graft intima compared to normal artery. PDGF-B chain mRNA was barely detectable in both ...tissues. PDGF mRNA levels within the graft interstices were not ...
10
Human keratinocytes are a major source of cutaneous platelet derived growth factor
... of PDGF in human dermal wound repair, the production of PDGF by human keratinocytes has not yet been ...of PDGF by cultured human keratinocytes. Both PDGF A and B chain mRNA can be detected in ...
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PDGF mediates cardiac microvascular communication
... of PDGF isoforms were as- sayed by two-antibody sandwich enzyme–linked immunoassay, as previously described ...to PDGF A, AF-221-NA (R&D Systems), was used as the capture antibody ...to PDGF A, ...
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Revascularization of ischemic tissues by PDGF CC via effects on endothelial cells and their progenitors
... not PDGF-AA, are capable of transmitting signals via PDGF-Rβ, when PDGF-Rβ is coexpressed with PDGF-Rα in ...ECs. PDGF-Rβ was, however, undetectable in our ECs, and thus the effect of ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... express PDGF mRNA in the ...contain PDGF-like mitogenic ...the PDGF protein isoforms and their receptors in this prosthetic graft ...both PDGF-A and PDGF-B were identified in ...
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Growth factors in periodontal regeneration: A review
... dependent. PDGF has been found to be produced by various other cells, monocytes, megakaryocytes, vascular endothelium, smooth muscles cells, and transformed cells (Ross et ...1990). PDGF contain two ...
6
β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer
... WNT, PDGF, vascular endothelial growth factor, and TGF-β signaling pathways in the KPA cancer cells (Figure ...that PDGF-B was the most highly activated gene in the KPA cancer cells (Figure ...higher ...
13
Original Article Blocking platelet-derived growth factor-d inhibits human lung cancer progression
... A549 cells treated with PDGF-D siRNA and scramble siRNA were seeded into the upper chamber (8 mm) (Corning, NY, USA) in serum- free medium. The complete medium was placed into the lower chamber. Following incu- ...
7
POU-domain transcription factors in the developing rat nervous system
... the PDGF-aR is restricted to the oligodendrocyte lineage, and th at the earliest oligodendrocyte precursors in the spinal cord originate in a very restricted region of the ventricular ...zone. PDGF-aR mRNA ...
181
Characterization of biologically active, platelet derived growth factor like molecules produced by murine erythroid cells in vitro and in vivo
... that PDGF-like biological activity was specifically immunoprecipitated by both monoclonal and polyclonal anti-human PDGF antibodies but not by antibodies to burst-promoting activity, granulocyte-macrophage ...
8
Ribozyme mediated gene knock down strategy to dissect the consequences of PDGF stimulation in vascular smooth muscle cells
... by PDGF-BB on both pro- ...different PDGF receptors. It is well-known that PDGF-BB binds both structurally similar protein- tyrosine kinase receptor subunits (PDGFR-α and PDGFR-β) and that ...
10
Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
... of PDGF-BB and FGF2 may also be of prognostic importance in heavily pre-treated ovarian cancer patients, and our results are partly in agreement with Schilder et ...plasma PDGF-AB, PDGF- BB, VEGF and ...
8
Antiproliferative Activity of Acerogenin C, a Macrocyclicdiarylheptanoid, on PDGF Induced Human Aortic Smooth Muscle Cells Proliferation
... in PDGF-Rβ and PDGF-BB triggers the PI3-K/PKB (Akt) and PLCγ1 pathways in addition to the ERK pathway ...as PDGF-BB share a final common signaling pathway in the cell ...
10
PDGF signaling in pulmonary arterial hypertension
... As PDGF has been implicated in these processes, Schermuly et ...altered PDGF signaling may be involved in the vascular remodeling observed in ...the PDGF receptor inhibitor STI571 in 2 different ...
5
Detection of platelet derived growth factor (PDGF) AA in actively healing human wounds treated with recombinant PDGF BB and absence of PDGF in chronic nonhealing wounds
... While PDGF-BB and PDGF-AB were present in a minority of healing wounds, they were usually present at lower levels than ...PDGF-AA. PDGF-beta receptors, which bind only PDGF-BB and not ...
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Expression of platelet derived growth factor (PDGF) related transcripts and synthesis of biologically active PDGF like proteins by human malignant epithelial cell lines
... both PDGF-1 and PDGF-2 genes. The levels of both PDGF-1 and PDGF-2 transcripts were superinduced when these cells were treated with cycloheximide, an inhibitor of protein ...125I-labeled ...
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