PDGF signaling
PDGF signaling in pulmonary arterial hypertension
... As PDGF has been implicated in these processes, Schermuly et ...altered PDGF signaling may be involved in the vascular remodeling observed in ...the PDGF receptor inhibitor STI571 in 2 ...
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Essential role for PDGF signaling in ophthalmic trigeminal placode induction
... for PDGF signaling in opV trigeminal placode formation using an alternative ...(dn) PDGF receptor β that was truncated and thus bound the ligand but failed to ...PDGFR signaling is necessary ...
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Original Article Xanthohumol inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of PDGF signaling pathway
... suppressed PDGF signaling pathway. A. HASMCs were stimulated with PDGF-BB for 30 min with or without pretreatment by various concentrations ...ERK1/2 signaling pathways activated by ...
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A role for PDGF signaling in expansion of the extra embryonic endoderm lineage of the mouse blastocyst
... the PDGF receptor family, could be expressed during this ...Lastly, signaling through other RTKs could compensate for the absence of PDGF ...KIT signaling is not essential in XEN cells, as ...
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Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling
... on PDGF signaling, and extension of cytoplasmic processes is not increased, but decreased on BCR overexpressing lfPDGFA, arguing against a direct role for PDGFA in the stimulation of protrusive ...
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Targeting the PDGF signaling pathway in tumor treatment
... clinically. PDGF has an accessory role in angiogenesis and, in particular, promotes pericyte recruitment to ...and PDGF signaling, targeting pericytes ...of PDGF-C [250]. However, the effect ...
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Review Article PDGF signaling in cancer progression
... that PDGF is close- ly associated with chemotherapy resistance of cancer ...(PDGF-D) signaling pathway plays a critical role in the acquisition of EMT phenotype of GR HCC cells ...of PDGF-D in ...
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Original Article Targeting the VEGF and PDGF signaling pathway in glioblastoma treatment
... Abstract: Growth factor receptors dysfunction has previously been correlated with glioma cell proliferation, ability to evade apoptosis, neo-angiogenesis and resistance to therapy. Antineoplastic molecules targeting ...
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Development and Application of Mass Spectrometry-based Approaches for Analysis of the PDGF Signaling Network.
... of PDGF have the ability to drive tumor growth (Yu et ...that PDGF can stimulate several signal transduction pathways including the Ras and PI3K pathway, as illustrated in Figure ...a signaling ...
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A naturally occurring carotenoid, lutein, reduces PDGF and H2O2 signaling and compromises migration in cultured vascular smooth muscle cells
... cellular signaling in VSMCs, it was found that lutein reduced PDGF signaling in a time- and concentration-dependent manner (Figures 1 and ...when PDGF was prein- cubated with lutein (Figure ...
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Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis
... [43]. PDGF signaling is one of the best characterized pathways of HSC activation ...[45]. PDGF induces activation of the downstream molecules Erk and Akt in activated HSCs, which is associated with ...
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β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer
... Figure 4. β-catenin activation induces constitutive activation of Src which could be repressed by the Src kinase inhibitor dasatinib. (A) The activity of various downstream mediators of the PDGF signaling ...
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The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease
... TGF signaling leading to a VEGF- dependant improvement in microvascular structure and function ...and PDGF-Rα- dependant regulation of VEGF expression in the injured neonatal lung ([50] (in ...
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Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
... reaction; PDGF: Platelet-derived growth factor; PDGFR- β : Platelet-derived growth factor receptor- β ; PFK: Phosphofructokinase; PI: Propidium iodide; PIMO: Pimonidazole; shRNA: Small hairpin RNA; STR: Short ...
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Growth factors in periodontal regeneration: A review
... Transforming growth factor-ᵦ (TGF-ᵦ): TGF-ᵦ belongs to TGF-ᵦ superfamily, which has many multifunctional structurally related growth and differentiation factors associated to the inflammatory response. These factors play ...
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Ribozyme mediated gene knock down strategy to dissect the consequences of PDGF stimulation in vascular smooth muscle cells
... by PDGF-BB on both pro- ...different PDGF receptors. It is well-known that PDGF-BB binds both structurally similar protein- tyrosine kinase receptor subunits (PDGFR-α and PDGFR-β) and that ...
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Antiproliferative Activity of Acerogenin C, a Macrocyclicdiarylheptanoid, on PDGF Induced Human Aortic Smooth Muscle Cells Proliferation
... The PDGF-BB-stimulated mitogenesis signaling pathway has been well ...of PDGF-BB to PDGF-Rβ can activate three major signal transduction pathways, PI3-K/Akt, PLCγ1 and ERK1/2, by activat- ing ...
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Relating phosphoinositide 3-kinase (PI3K) signaling and cell motility dynamics during PDGF-stimulated chemotaxis
... of signaling pathways such as the effect myosin II has on actin filament crosslinking during cell motility (Laevsky & Knecht, 2003), the importance of efficient cytokinesis (Nagasaki & Uyeda, 2008), the ...
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Endothelial and nonendothelial sources of PDGF B regulate pericyte recruitment and influence vascular pattern formation in tumors
... of PDGF-B and/or by providing a pericyte-adhesive matrix. PDGF-B secretion by the tumor cells would be expected to direct pericyte migration away from the vessels if the PDGF-B concen- trations ...
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Original Article PDGF-Rb and microRNA-329 are associated with endometrial dysfunctionvia targeting CD146
... tinct PDGF isoforms, especially PDGF-BB, have been shown to stimulate endometrial cell prolif- eration, invasiveness and migration ...over, PDGF can induce endometrial cell prolif- eration and ...
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