PDZ domain binding motif
Role of the PDZ Domain-Binding Motif of the Oncoprotein E6 in the Pathogenesis of Human Papillomavirus Type 31
... of PDZ domain-containing proteins have been identified as binding partners for the oncoprotein E6 of the high-risk type human papillomaviruses ...The PDZ domain-binding ...
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PDZ domain binding motif of human T cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T cell line
... the PDZ domain-binding motif (PBM) located at the Tax1 C-termi- nus, S/TXV (S/T, serine or threonine; X, any amino acid; V, valine), is responsible for the high CFSA activity relative to Tax2 ...
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An RNA aptamer targets the PDZ-binding motif of the HPV16 E6 oncoprotein.
... a PDZ domain (post synaptic density protein, Drosophila disc large tumour suppressor, zonula occludens-1 ...understood. PDZ-domain containing proteins include hScrib [14], MUPP1 [15] and ...
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Distinct functions of HTLV 1 Tax1 from HTLV 2 Tax2 contribute key roles to viral pathogenesis
... Large/ZO-1) domain containing pro- teins bind to the PDZ domain binding motif (PBM) which is typically present at the carboxyl-terminus of tar- get proteins ...
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Synergistic Effect of the PDZ and p85β-Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus
... virus-type PDZ domain-binding motif ESEV (which affects virulence) was replaced with ESKV, and NS1-138F (which is highly conserved among all influenza A viruses and may affect the activation ...
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Molecular characterization and ligand binding specificity of the PDZ domain containing protein GIPC3 from Schistosoma japonicum
... The PDZ domain is one of the most important PPI modules, and is emergently regarded as a novel target of drug discovery ...[8,9]. PDZ domains are built of approxi- mately 70 to 90 residues and form a ...
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Opposing Effects of a Tyrosine-Based Sorting Motif and a PDZ-Binding Motif Regulate Human T-Lymphotropic Virus Type 1 Envelope Trafficking
... cytoplasmic domain, which showed that muta- tions of critical amino acids in the YSLI element ...YSLI motif in HTLV-1 Env mediates interactions with AP2 and AP3 that play major roles in the control of Env ...
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The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C α and GluR2 as Interacting Ligands
... I PDZ binding motif, whereas GluR2 has a type II PDZ binding ...the PDZ domain of protein interacting with protein kinase C (PICK1), and PICK1-PKC ␣ -controlled ...
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The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity
... a PDZ binding motif (PBM) in the human papillomavi- rus (HPV) E6 oncoprotein appears to be a characteristic marker of high oncogenic potential and confers interaction with a number of different ...
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Schlehe, Julia (2008): Folding, function and subcellular localization of parkin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... to PDZ domains of interaction partners. PDZ domains are modular protein interaction domains of 80-90 amino acids in length involved in transport, localization and assembly of multiprotein signalling ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... transmembrane domain of SR-BI is responsible for binding cholesterol, we performed comparable photocholesterol binding studies with ...photocholesterol binding comparable to that of wild-type ...
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<p>Silencing of TAZ inhibits the motility of hepatocellular carcinoma cells through autophagy induction</p>
... with PDZ-binding motif (TAZ), also known as WW domain containing tran- scription regulator 1, is one of the Hippo downstream effectors responsible for mediating the vast majority of the ...
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The Avian Influenza Virus NS1 ESEV PDZ Binding Motif Associates with Dlg1 and Scribble To Disrupt Cellular Tight Junctions
... L27 domain (5), we suspected that Dlg1 may allow Lin7C to associate with the avNS1-ESEV protein through an indirect ...for binding to the avian influenza NS1 protein in vitro. (A) Domain structure of ...
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Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals
... a binding partner for Tax oncoprotein of T- lymphotropic virus type 1 (HTLV-1) by yeast two-hybrid screening ...single PDZ domain (Figure ...C-terminus PDZ-binding motif of ...
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High-Risk Human Papillomavirus E6 Oncoproteins Interact with 14-3-3ζ in a PDZ Binding Motif-Dependent Manner
... to recognize phosphorylated substrates and thereby directly mod- ulate their respective modes of action. In the case of the high-risk HPV E6 oncoproteins, an important aspect of their ability to con- tribute to the ...
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Investigating the Binding of Peptidyl-Prolyl Isomerase Pin1 to a Multi-Site Phosphorylated Substrate Modeled After Phosphatase CDC25C
... WW domain was inserted into the ...WW domain in non-specific interactions that push Pin1 into large in vivo ...Pin1 binding to CDC25C and CDC25C-derived peptides in vivo as a method to understand the ...
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PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking
... manner to wrap around the receptors (Gurevich and Gurevich 2004), in contrast, more recent studies suggest that the N- and C- terminal domains of the activated arrestin undergo a 20° rotation from the central axis and ...
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Neuromuscular Synaptic Proteins In Development And Regeneration
... phosphotyrosine-binding domain highly homologous to the Dok-7 PTB domain (72% identity between PTB domains, 46% identity overall; “uncharacterized protein” LOC100331748, ...PTB domain can bind ...
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Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA
... high degree of homology to tapasin and were acquired from the UK HGMP resource centre (www.hgmp.mrc. ac.uk) and sequenced. One of the clones revealed a 2202 bp sequence (Genbank, accession AF067286) that was identical to ...
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Dicarbonyl stress and dysfunction of the glyoxalase system in periodontal diseases
... Atlastin-3 Ribosome-binding protein 1 Thyroid hormone receptor-associated protein 3 Isoform 2 of Presequence protease, mitochondrial PDZ and LIM domain protein 1 Isoform 2 of 5'-nucleoti[r] ...
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