PEGylated liposomes
Mechanistic study of decreased skin penetration using a combination of sonophoresis with sodium fluorescein-loaded PEGylated liposomes with D-limonene
... Abstract: The effect of low frequency sonophoresis (SN, 20 kHz) on the skin transport of sodium fluorescein (NaFI)-loaded liposomes was investigated. An in vitro skin penetration study in open and blocked hair ...
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Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes
... of PEGylated agents by αPEG Abs is important as αPEG Abs have been reported to reduce serum half-life and therapeutic efficacy in the ...of PEGylated agents may help to use these therapies ...of ...
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Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2–3: an adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells
... in liposomes was shown to markedly enhance the intracellular epirubicin uptake and mainly localized into the ...with PEGylated liposomes of hepcidin 2–3 and epirubicin caused programmed cell death in ...
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Clinical pharmacokinetics and pharmacocynamics of anticancer agents delivered via PEGylated liposomes
... conventional liposomes increase proportionately with increasing lipid ...conventional liposomes may due to a combination of saturation of MPS (63) and due to depletion of serum opsonins at high lipid doses ...
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The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia
... the PEGylated liposomes. After injection of the formulated proteins to the bloodstream the liposomes associate with non-activated platelets and a complex of platelet-PEGLip- protein (FVIII/FVIIa) is ...
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<p>Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer</p>
... PTX-loaded PEGylated liposomes were prepared by fi lm dispersion- ultrasonic method and modi fi ed by an N,N-dimethyl tertiary amino ...PTX-loaded liposomes were observed by transmission electron ...
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Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes
... bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical ...Bufalin-loaded PEGylated liposomes and bufalin-loaded liposomes ...
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Luteinizing hormone-releasing hormone receptor-mediated delivery of mitoxantrone using LHRH analogs modified with PEGylated liposomes
... gonadorelin-modified liposomes, the extent of cellular uptake of different liposomal formulations was evaluated by confocal laser scanning fluorescence microscopy in LHRH receptor overexpressing or low-expressing ...
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Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma
... Abstract: Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, a doxorubicin ...
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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference?
... GSH-PEG-HSPC liposomes (referred to as “GSH-PEG-HSPC”) (n = 7), PEG-HSPC liposomes (referred to as “PEG-HSPC”) (n = 7), GSH-PEG-EYPC liposomes (referred to as “GSH-PEG-EYPC”) (n = 7), PEG-EYPC ...
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An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery
... pH-sensitive PEGylated liposomes (CPPL) to improve the selectivity of these peptides for tumor ...on liposomes was screened to guaranty a maximum targeting efficiency on tumor cells as well as not ...
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Efficient downregulation of VEGF in retinal pigment epithelial cells by integrin ligand-labeled liposome-mediated siRNA delivery
... ARPE-19 cell transfection study. Expression of the VEGF gene in ARPE-19 was investigated at the mRNA level by reverse transcriptase-polymerase chain reaction (RT-PCR). Briefly, siRNA-loaded 3 mol% PEGylated ...
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Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs
... named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resis- tance, and increase ...
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“Liposomal Paclitaxel: Recent Trends and Future Perspectives” by Neeraj K. Sharma, Vimal Kumar, India.
... Some of the vascular barriers of tumors are represented by heterogeneous blood flow, expression of efflux transporters, high intercapillary distance, and extracellular matrix components. The key problem with the use of ...
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Preparation of PEGylated Liposomal Ginsenoside;Formulation Design and in vitro Evaluation
... Rg3-loaded PEGylated liposomes were prepared and optimized using the Box- Behnken ...These liposomes were characterized, the cumulative release profiles were investigated and compared with ...
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Adhesion characteristics and stability assessment of lectin modified liposomes for site specific drug delivery
... The PEGylated liposomes formed a very sensitive layer on the sensor ...the liposomes on the model mem- brane surface: Following the injection, liposomes adhere tightly packed onto the sensor ...
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Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer
... [18]. Pegylated liposomes with suitable particle sizes have been demonstrated to improve the therapeutic index of drugs by prolonged circulation in the blood and enhanced tumor accumulation in cancer tissue ...
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Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy
... of PEGylated liposomes within a certain dose range induced the rapid clearance of subsequently injected PEGylated liposomal ...from liposomes in the first 30 minutes in a ...
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Oleanolic acid liposomes with polyethylene glycol modification: promising antitumor drug delivery
... 2 mL of anhydrous ethanol as the lipid phase, which was continuously stirred at 43 ° C. Tween-80 (0.2% [v/v] in the aqueous phase) and PEG-2000 were dissolved in 10 mL of phosphate-buffered saline (pH 6.5) in a water ...
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Preparation, characterization, and <em>in vitro</em> release study of albendazole-encapsulated nanosize liposomes
... PEGylated liposomes. Comparing the results of both con- ventional and PEGylated liposomal formulations of the same composition and molar ratio, it is obvious that PEGylated liposomes ...
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