pemphigus vulgaris
Dermatologic and Oral Manifestations of Pemphigus Vulgaris: A Case Report with Review.
... A biopsy was obtained from a perilesional site on the right buccal mucosa under local anesthesia and submitted for routine histopathological examinations in buffered formalin. Sections stained with H and E revealed the ...
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A brief review of pemphigus vulgaris
... Pemphigus vulgaris (PV) is a debilitating dermatologic condition that is autoimmune in nature. It can be life threatening and can have a mortality rate between 5 and 15% (Razzaque Ahmed and Moy 1982). ...
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PEMPHIGUS VULGARIS: AN UPDATE ON ETIOPATHOGENESIS, CLINICAL MANIFESTATIONS, DIAGNOSIS AND TREATMENT MODALITIES
... suggested that the distribution and expression levels of Dsg1 and Dsg3 might account for the characteristic blisters distribution and localization in PV and PF patients. Microscopic studies have demonstrated the ...
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PEMPHIGUS VULGARIS: AN INSIGHT ON CONVENTIONAL AND EMERGING TREATMENT MODALITIES
... Rituximab is a chimeric monoclonal antibody that targets the B cell differentiation antigen CD20, an integral membrane protein that participates in B cell activation and proliferation. It is found on pre-B cells, ...
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Emerging treatment options for the management of pemphigus vulgaris
... Pemphigus vulgaris (PV) is a rare and life-threatening disease belonging to the pemphigus group of autoimmune intra-epidermal bullous diseases. Pathophysiologi- cally, the underlying intraepithelial ...
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Pemphigus Vulgaris: The Eyes Have It
... therapy, pemphigus was usually fatal. Pemphigus is rare in childhood, and the diagnosis is usually not consid- ered at the time signs first ...with pemphigus vulgaris (PV) who pre- sented with ...
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Study of HLA DR and DQ Types in Patients with Pemphigus Vulgaris as Compared to that in Healthy Subjects
... 3 patients. Other conditions that were a chance occurrence, seen in one patient each were hepatitis C, HIV, bronchial asthma, atopy and adjustment disorder. Single patient at the time of inclusion had retroperitoneal ...
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Management of pemphigus vulgaris: challenges and solutions
... of pemphigus vulgaris is to control the disease, prevent relapses, and avoid adverse events associated with the prolonged use of steroids and immunosuppressive ...recalcitrant pemphigus, when other ...
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Defining Mechanisms of Autoimmunity in Pemphigus Vulgaris
... A prominent question in the field of autoimmunity is how these diseases arise. Currently, the etiologies of many autoimmune diseases remain unclear. The work described here provides insight into this question in the ...
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Disseminated Strongyloidiasis in an Immunodeficient Patient (Pemphigus Vulgaris) Due to Corticosteroid Therapy: A Case Report
... Firstly, it must be emphasized that the pa- tient history should be more considered by physicians, especially in immunodeficiency disorders like pemphigus vulgaris, lupus, lym- phoma, and rheumatoid ...
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An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life
... Objectives: To study use, effect and adverse drug reaction (ADR) of the drugs and its impact on quality of life in patients suffering from Pemphigus vulgaris (PV). Materials and Methods: Prospective, ...
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Pemphigus vulgaris macroscopically and cytologically resembling oral squamous cell carcinoma
... We describe the clinical, macroscopic, cytological, his- topathological, immunohistochemical, serodiagnostic and aspects of pemphigus vulgaris (PV) in the oral gingiva that clinically mimicked oral squamous ...
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Isolation and purification of a pemphigus vulgaris antigen from human epidermis
... with pemphigus vulgaris serum, or 20 control sera, and detected with fluorescein labeled antisera to human ...of pemphigus vulgaris antibody to tissue sections, we studied the binding of the ...
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Management of a rare chronic blistering autoimmune skin disease: Pemphigus Vulgaris
... Pemphigus vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous ...of pemphigus, pemphigus vulgaris, pemphigus foliaceous, pemphigus ...
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Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen
... Immunoprecipitations of cultured keratinocyte extracts have shown that pemphigus vulgaris (PV) sera bind a polypeptide of 210,000 mol wt with disulfide-linked chains of 130,000 and 85,000 mol wt. To ...
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Study of Extrinsic Apoptotic Pathway in Oral Pemphigus Vulgaris Using TNFR 1 and FasL Immunohistochemical Markers and TUNEL Technique
... to pemphigus autoantibodies, which conse- quently both stimuli induced apoptosis and then accu- mulation of apoptotic cells reinforced or furthered high- er production of TNFα by monocytes or macrophages that in ...
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Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study
... with pemphigus and could, in our opinion, be explained by the two theories men- tioned above, regarding the presence of a subsequently increased disease activity or an increased cardiovascular risk, due to the ...
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Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies
... To confirm that PF antibodies, which specifically bound to a 160,000-mol wt protein band on immunoblots, were actually pemphigus antibodies, we eluted the IgG from the protein that was c[r] ...
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Setting the target for pemphigus vulgaris therapy
... in pemphigus has been described previ- ously (9), DSG3 autoantibodies represent the major etiologic culprit of the disease, as several lines of evidence have shown they are both necessary and sufficient for the ...
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Socioeconomic status of patients with pemphigus vulgaris
... In this case–control study, level of SES of patients with new onset PV was evaluated and compared with a control group from September 2014 to March 2015. The cases were patients who were suffering from immunobullous ...
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