PENTACYCLIC TRITERPENE
A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis
... Here we showed that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion and migration. This effect was accompanied ...
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I An Investigation of the Utility of the Claisen Rearrangement in Angular Methylation as Illustrated by the Synthesis of 1 valeranone II The Total Synthesis of the Pentacyclic Triterpene d1 germanicol
... PART I AN INVESTIGATION OF THE UTILITY OF THE CLAISEN REARRANGEMENT IN ANGULAR METHYLATION AS ILLUSTRATED BY THE SYNTHESIS OF 1-VALERANONE PART II THE TOTAL SYNTHESIS OF THE PENTACYCLIC [r] ...
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ISOLATION AND STRUCTURE ELUCIDATION OF A PENTACYCLIC TRITERPENE FROM STEM BARK OF Ficus sycomorus
... Isolation, purification, characterization and antimicrobial Activity: a successful column separation of the ethanol extract led to the isolation of compound FA coded JBFS03, which was id[r] ...
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A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats
... A pentacyclic triterpene, oleanolic acid, has also been reported to enhance the insulin signaling pathway in the skeletal muscle of STZ-induced diabetic rats ...
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PHYTOCHEMICAL ANALYSIS OF AVICENNIA OFFICINALIS OF KRISHNA ESTUARY
... in its EI mass spectrum. It gave a positive Liebermann- Burchard test for triterpenoids and IR spectrum showed hydroxyl (3450 cm -1 ) and methylene (880 cm -1 ) absorptions. The 1H NMR spectra showed five tertiary ...
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Anti-enterococcal activities of pentacyclic triterpenes
... ences in the chemical structure of the examined triter- penes (Fig. 1). The number of hydroxyl and methyl groups is different in AA and UA. It should be noted that AA has 6 methyl groups attached to C4, C8, C10, C14, ...
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A Review of the Occurrence of Non-Alkaloid Constituents in Uncaria Species and Their Structure-Activity Relationships
... as pentacyclic triterpenoids (V) and triterpenes saponin (VI) have been also reported in various Uncaria genus [12] (Figure 3, Table ...3). Pentacyclic triterpene esters, such as uncarinic acids A-E ...
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Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice
... the pentacyclic triterpene α , β -amyrin isolated from Protium heptaphyllum exerts antihyperglycemic and hypolipi- demic effects in mouse models of STZ-induced diabetes and high-fat diet-induced ...
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Isolation and characterization of lupeol from methanolic extract of leaves of andrographis echioides
... hopanes). Pentacyclic triterpenes are produced by arrangement of squalene epoxide molecules (Sholichin et ...a pentacyclic triterpene was isolated and characterized for the first time, from the ...
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PENTACYCLIC TRITERPENOIDS WITH ANTIMICROBIAL ACTIVITY FROM THE LEAVES OF VERNONANTHURA PATENS (ASTERACEAE)
... position , and that when the hydroxyl is in beta , this chemical shift occurs at 3.20 ppm. Two doublets for proton to an exocyclic methylene to δ 4.57 (2H, d, J=2.1 Hz, H-29) and 4.69 (2H, d, J=2.1 Hz, H-29). 13CNMR ...
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Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism
... A: Transmission electron microscopic appearance of midbrain Control group 1; B1: low resolution of MPTP induced group II; B2: high resolution of MPTP induced group II; C: MPTP induced + [r] ...
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PHYTOPHARMACOLOGY OF UNCARIA TOMENTOSA: A REVIEW
... The pentacyclic oxindole alkaloids inhibited the growth, median inhibitory concentration 10 -5 -10 - 4 mol/l; the most pronounced effect was found for Uncarine F [58] ...
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Structural Elucidation of a New Novel Pentacyclic Triterpenoid Isolated from Caralluma Attenuata Root
... [24-31], triterpene saponins [32], flavonoids [33], pregnane esters [34], bisdesmosidic glycosides [35,36], flavone glycosides [37], were earlier reported from the same ...novel pentacyclic triterpenoid ...
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Anti-Inflammatory Activity of Nanogel Formulation of 3-Acetyl-11-Keto-Β-Boswellic Acid
... The gum of Boswellia serrata has been widely used in ayurvedic and traditional system of medicine for the treatment of inflammation. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent pentacyclic ...
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Protective Effect of Wrightia Tinctoria Bark Triterpenoidal Fraction on Ccl4-Induced Acute Rat Liver Toxicity
... the Triterpene fraction preserved the structural integrity of the plasma cellular membrane of the hepatocytes and protected it from breakage by the reactive metabolites ...
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Fluorescence Spectroscopy and Molecular Docking Approach to Probe the Interaction between Dehydroeburicoic Acid and Human Serum Albumin
... a triterpene purified from medicinal fungi and the major transport protein, human serum albumin (HSA), were systematically studied by fluorescence spectroscopy, synchron- ous fluorescence spectroscopy, ...
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Sensitivity to a Nonpeptidic Compound (RPR103611) Blocking Human Immunodeficiency Virus Type 1 Env-Mediated Fusion Depends on Sequence and Accessibility of the gp41 Loop Region
... 2142 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The triterpene RPR103611 is an efficient inhibitor of membrane fusion mediated by the envelope proteins Env, gp120-g[r] ...
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SAPINDUS MUKOROSSI (AREETHA): AN OVERVIEW
... Phytoanalytical methods: A colorimetric assay method for the estimation of total saponin content of Sapindus mukorossi was reported by Diwedi et al 23 . High performance thin layer chromatography (HPTLC) as well as high ...
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Novel Diazole/Triazole and Dibenzothiophene Dioxide Containing Pentacyclic Systems with Promising Biological Activities
... heterocyclic pentacyclic condensed systems that combine benzothiophen and benzimidazole/triazole into one ...new pentacyclic systems were produced: 3H-, 7H-di- imidazole[4,5-b][5,4-g] ...
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Chemical Composition of the Cuticle Membrane of Pitaya Fruits ( Hylocereus Polyrhizus
... and pentacyclic triterpenoids were detected in pitaya cuticular wax mixtures (Figure 3 and Supplementary Table ...of pentacyclic triterpenoids ...The pentacyclic triterpenoids contained various ...
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